Abstract: The present disclosure relates to certain (2S)—N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: Disclosed are network managed volumes that enable simplified and more efficient use of information technology assets by allocating physical disk drives as needed. A pool of storage can be defined and populated with physical disks that are accessible in a storage area network. Virtual volumes are created from the storage pool, with each virtual volume being separately allocable to a host device (e.g., client, application server, etc.). Thus, host devices that have been allocated these virtual volumes perceive ownership of the entire volume, without requiring a present allocation of physical storage space having the same characteristics, but with seamless introduction of physical resources as needed.