Patents by Inventor Nicholas Constantine Zachos

Nicholas Constantine Zachos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions which regulate the epithelial brush border Na/H exchanger NHE3 and their methods of use in gastrointestinal disease
    Patent number: 9850292
    Abstract: A synthetic peptide modeled on the IRCX binding area of NHE3, is a competitive inhibitor of the IRCX and both stimulates basal NHE3 activity and prevents elevated Ca2+ and cAMP inhibition of NHE3. Methods of its preparation and use in the prevention and/or treatment of gastrointestinal disease, such as diarrhea are provided.
    Type: Grant
    Filed: May 17, 2013
    Date of Patent: December 26, 2017
    Assignees: The Johns Hopkins University, The Penn State Research Foundation
    Inventors: Mark Donowitz, Nicholas Constantine Zachos, Damian Brett Van Rossum, Randen Patterson
  • COMPOSITIONS WHICH REGULATE THE EPITHELIAL BRUSH BORDER Na+/H+ EXCHANGER NHE3 AND THEIR METHODS OF USE IN GASTROINTESTINAL DISEASE
    Publication number: 20150139956
    Abstract: A synthetic peptide modeled on the IRCX binding area of NHE3, is a competitive inhibitor of the IRCX and both stimulates basal NHE3 activity and prevents elevated Ca2+ and cAMP inhibition of NHE3. Methods of its preparation and use in the prevention and/or treatment of gastrointestinal disease, such as diarrhea are provided.
    Type: Application
    Filed: May 17, 2013
    Publication date: May 21, 2015
    Inventors: Mark Donowitz, Nicholas Constantine Zachos, Damian Brett Van Rossum, Randen Patterson