Abstract: A fluidic cartridge for mixing a fluid sample with a reagent can include a sample reservoir and a reagent reservoir. The fluidic cartridge can also include a plurality of mixing channels and an imaging chamber. The plurality of mixing channels can define a three-dimensional geometry having a plurality of nodes through which the fluid sample and the reagent flow. The imaging chamber is in fluid communication with the plurality of mixing channels and is dimensioned to receive an analyzable mixture of the fluid sample and the reagent.