Abstract: Compounds of Formula (I): wherein R1, R3, R11, R12, X, Y1, Y2, Y3, Y4 and are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring anti-apoptotic inhibitors.

Abstract: An environment of sensors and actuators is operated in accordance with predetermined policies, and the effectiveness of individual policies is monitored by comparing inputs from the sensors (550) with intended outcomes from policies controlled by previous inputs from one or more of the same sensors. Each policy includes a check function (554), wherein a sensor, other than the one that triggers the actions, monitors the actions generated by the policy and generates an output (556) indicative of whether a system state is approaching a condition specified by the policy.

Abstract: An environment of sensors and actuators is operated in accordance with predetermined policies, and the effectiveness of individual policies is monitored by comparing inputs from the sensors (550) with intended outcomes from policies controlled by previous inputs from one or more of the same sensors. Each policy includes a check function (554), wherein a sensor, other than the one that triggers the actions, monitors the actions generated by the policy and generates an output (556) indicative of whether a system state is approaching a condition specified by the policy.

Abstract: A hood (110) for mounting to a child carrier, the hood comprising a pair of side walls 16a, 116b, a top wall (120) and a mar wall (118) defining a compartment therebetween. The hood further comprises a first fan unit (126) comprising a fan configured, in use, to draw ambient external air into the compartment, and a second fan unit (128) comprising a fan configured, in use, to draw air from within the compartment to the environment outside the compartment. The first and second fan units are mounted and sealed within a respective opening in a different respective one of the side walls, top wall and rear wall such that, in use, an air flow path is defined through a volume of the compartment between the first and second fan units. A removable cover assembly is also provided.

Abstract: A device may receive trial information that identifies rules or requirements associated with a clinical trial. The device may identify a set of participants associated with the clinical trial. The device may automatically obtain, from a user device associated with a particular participant, of the set of participants, first information regarding the particular participant. The first information may relate to a biometric of the particular participant or an environment associated with the particular participant. The device may determine that the first information indicates that the particular participant does not satisfy a particular rule or requirement associated with the clinical trial. The device may provide, to the user device, a prompt indicating that the particular participant does not satisfy the particular rule or requirement. The device may store or provide the first information for addition to a profile associated with the particular participant.

Abstract: A security device to be attached to a retail product, wherein the device indicates the only authorized point or channel of sale and a method for deterring the theft and resale of goods. The method can include identifying a product which is likely target for theft and resale, identifying an appropriate distinguishing device to clearly indicate the authorized point or channel of sale, and applying the distinguishing device to the product.

Abstract: A hot melt ink comprising, ionomers and an image-forming agent, wherein the melting point of the ionomers is from about 50.degree. C. to about 130.degree. C., said ink exhibiting, in the molten stage, a viscosity from about 5 to about 60 centipoises (cps) at about 90.degree. to 140.degree. C. A method for ink jet printing comprising application of said ink in the molten state is also disclosed. A hot melt ink jet composition comprising a solid carrier component, an image-forming composition, and from about 5 to about 75 percent, by weight of an emulsifier is also disclosed, and the use thereof for ink jet printing.

Abstract: A hot melt ink comprising, a eutectic composition and an image-forming agent, wherein the melting point of the eutectic composition is from about 80.degree. C. to about 130.degree. C. and the compounds present in the eutectic compositions have melting points of at least about 100.degree. C. Also disclosed is a method for ink jet printing comprising:(a) providing a thermally reversible hot melt ink which is a solid at ambient temperature and a liquid at temperatures between about 80.degree. C.-130.degree. C., said ink comprising:(i) a eutectic composition; and(ii) an image-forming composition;(b) elevating the temperature of said eutectic composition to between about 90.degree. C. and about 140.degree. C., to cause said ink to form a liquid solution or suspension of said image-forming composition;(c) jetting said ink onto a substrate in the form of images;(d) allowing said ink to crystallize upon cooling on said substrate.

Abstract: A hot melt ink composition for use in continuous ink jet printing comprising an electrolyte, an electrolyte-solvating and dissociating compound and an image-forming agent, said ink being solid at about 25.degree. C., said ink liquefying at a temperature between 75.degree. C. and 175.degree. C., and said ink in the liquid stage having a conductivity of greater than about 100 microsiemens/cm.

Abstract: A smoothing layer is provided between the rough etched sides of a channel in a substrate in which an optical waveguiding material is to be produced. Losses are substantially reduced thereby. For a rectangular or rib waveguide, where the sides of the rib are left rough by etching, a smoothing layer is again provided over the rib. The smoothing layer preferably has a refractive index close to or the same as the materials having surface roughness.