Patents by Inventor Nicholas Donald Keul

Nicholas Donald Keul has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • OPTIMIZED BIOSYNTHESIS PATHWAY FOR CANNABINOID BIOSYNTHESIS
    Publication number: 20240401001
    Abstract: Provided herein are cells, enzymes, and methods for improved cannabinoid production.
    Type: Application
    Filed: October 17, 2022
    Publication date: December 5, 2024
    Inventors: Spiros Kambourakis, Russell Scott Komor, Nicholas Donald Keul, Nicky Christopher Caiazza, Jun Urano, Diep Minh Ngoc Nguyen
  • ENGINEERED ENZYMES, CELLS, AND METHODS FOR PRODUCING CANNABINOID PRECURSORS AND CANNABINOIDS
    Publication number: 20240360425
    Abstract: Described herein are the discovery and/or optimization of enzymes involved in the biosynthesis of olivetolic acid, divarinic acid, and analogs thereof.
    Type: Application
    Filed: May 13, 2022
    Publication date: October 31, 2024
    Inventors: Spiros Kambourakis, Nicholas Donald Keul, Russell Scott Komor, Jun Urano, Nicky Christopher Caiazza
  • ENGINEERED CELLS, ENZYMES, AND METHODS FOR PRODUCING CANNABINOIDS
    Publication number: 20240228986
    Abstract: Disclosed herein are novel CBGA and CBGVA synthases and methods for improvement of their overall activities for the synthesis of CBGA and CBGVA from their respective precursors, olivetolic acid (OA) or divarinic acid (DVA) and GPP. Also disclosed are fusion proteins to enhance synthesis of CBGA and CBGVA. The methods described herein also increase the titer and the purity of CBGA and CBGVA made by a cell by 1) decreasing the formation of byproducts FCBGA and FCBGVA that are synthesized from the respective prenylation of OA and DVA with FPP, and/or 2) increasing the intracellular availability of OA and DVA.
    Type: Application
    Filed: May 13, 2022
    Publication date: July 11, 2024
    Inventors: Spiros Kambourakis, Nicholas Donald Keul, Russell Scott Komor, Jun Urano, Nicky Christopher Caiazza