Abstract: A method for providing a lung disease risk measure in a Computer Aided Diagnosis system is described. The method comprising the steps of: receiving a plurality of inputs for a subject, each input comprising at least one image showing all or part of the lungs of a patient and a time stamp for the image, where the inputs are obtained at varying intervals; analysing the inputs to assess temporal changes in the images using at least one of an input data encoder and a time stamp encoder; inputting the output of at least one of the encoders to a score calculator to calculate a risk score; outputting the risk score indicating the lung disease risk for the subject. A Computer Aided diagnosis system for implementing the method is also described.

Abstract: A CADx system and method for analysing a medical image from a local population for a disease risk score and determining if the system is calibrated is described. The CADx system comprising :an input circuit for receiving at least one medical image and producing CADx derived data based on the received image; a machine learning model for determining a disease risk score for the medical image; a calibration auditor circuit for determining a calibration state of the CADx system by: receiving the CADx derived data and comparing the CADx derived data to training derived data, where the training derived data comprises one of more of: training data for the machine learning model for determining the disease risk score, and data on population factors associated with the training data; and an output circuit for outputting a disease risk score for the medical image and an indication of the calibration state.

Abstract: A method for providing a lung disease risk measure in a Computer Aided Diagnosis system is described. The method comprising the steps of: receiving a plurality of inputs for a subject, each input comprising at least one image showing all or part of the lungs of a patient and a time stamp for the image, where the inputs are obtained at varying intervals; analysing the inputs to assess temporal changes in the images using at least one of an input data encoder and a time stamp encoder; inputting the output of at least one of the encoders to a score calculator to calculate a risk score; outputting the risk score indicating the lung disease risk for the subject. A Computer Aided diagnosis system for implementing the method is also described.

Abstract: A method for providing a lung disease risk measure in a Computer Aided Diagnosis system is described. The method comprises the steps of: receiving an input comprising at least one input image showing all or part of the lungs of a patient; analysing the input to identify a feature descriptor comprised of at least one feature group, where each feature group comprises at least one feature computed from the input image; calculating a score explanation factor for each feature group, and an overall disease risk score for the patient's risk of lung disease from the feature descriptor; outputting the overall disease score risk score and a corresponding score explanation factor for each feature group. A computer aided diagnosis system is also described, along with a method for training a computer aided diagnosis system.

Abstract: A Computer Aided Diagnosis, CAD, lung disease risk measure system is described that comprises: an input circuit configured to receive at least one input medical image of a patient in which the patient's lungs are visible. A smoking history system is operably coupled to the input circuit and configured to receive and analyse the at least one input medical image of a patient and determine an equivalent smoking history of the patient based on the at least one input medical image and output a smoking history parameter based on the determined equivalent smoking history of the patient.