Patents by Inventor Nicholas E. Hill

Nicholas E. Hill has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Trioxacarcins and uses thereof
    Patent number: 9611287
    Abstract: The present invention relates to trioxacarcin compounds of the formula: or pharmaceutically acceptable forms thereof; wherein R1, R2, R3, R4, R5, R6, R7, R8, and R9 are as defined herein. The present invention also provides processes for preparing such compounds and intermediates thereto; pharmaceutical compositions comprising such compounds; and methods of use and treatment.
    Type: Grant
    Filed: July 28, 2015
    Date of Patent: April 4, 2017
    Assignee: President and Fellows of Harvard College
    Inventors: Andrew G. Myers, Nicholas E. Hill, Jakub Svenda, Robert T. Yu, Daniel J. Smaltz, Thomas Magauer
  • TRIOXACARCINS AND USES THEREOF
    Publication number: 20160355537
    Abstract: The present invention relates to trioxacarcin compounds of the formula: or pharmaceutically acceptable forms thereof; wherein R1, R2, R3, R4, R5, R6, R7, R8, and R9 are as defined herein. The present invention also provides processes for preparing such compounds and intermediates thereto; pharmaceutical compositions comprising such compounds; and methods of use and treatment.
    Type: Application
    Filed: July 28, 2015
    Publication date: December 8, 2016
    Applicant: President and Fellows of Harvard College
    Inventors: Andrew G. Myers, Nicholas E. Hill, Jakub Svenda, Robert T. Yu, Daniel J. Smaltz, Thomas Magauer
  • Harsh environment connector with rolling seals
    Patent number: 9246261
    Abstract: An underwater rolling seal connector assembly has releasably mateable connector units with one or more rolling seals mounted in front faces of units. The rolling seals are rotatable back and forth between a closed position sealing one or more chambers within the respective units which contain one or more contacts and an open position in which bores through the seals are open to allow contacts in one unit to pass through the seal openings and engage contact in the other unit. A shell of one connector unit has inwardly facing cam formations and each rolling seal has outwardly directed eccentric rotators configured for engagement with respective cam formations on mating and de-mating of the connector units, whereby travel of the respective rotators along the respective cam formations during mating and de-mating rotates the rolling seals into the open and closed positions, respectively.
    Type: Grant
    Filed: March 27, 2014
    Date of Patent: January 26, 2016
    Assignee: Teledyne Instruments, Inc.
    Inventors: Jonathan R. Hatcher, William S. Taylor, Justin M. Kretschmar, Nicholas E. Hill
  • Harsh Environment Connector With Rolling Seals
    Publication number: 20150280355
    Abstract: An underwater rolling seal connector assembly has releasably mateable connector units with one or more rolling seals mounted in front faces of units. The rolling seals are rotatable back and forth between a closed position sealing one or more chambers within the respective units which contain one or more contacts and an open position in which bores through the seals are open to allow contacts in one unit to pass through the seal openings and engage contact in the other unit. A shell of one connector unit has inwardly facing cam formations and each rolling seal has outwardly directed eccentric rotators configured for engagement with respective cam formations on mating and de-mating of the connector units, whereby travel of the respective rotators along the respective cam formations during mating and de-mating rotates the rolling seals into the open and closed positions, respectively.
    Type: Application
    Filed: March 27, 2014
    Publication date: October 1, 2015
    Applicant: Teledyne Instruments, Inc.
    Inventors: Jonathan R. Hatcher, William S. Taylor, Justin M. Kretschmar, Nicholas E. Hill
  • Trioxacarcins and uses thereof
    Patent number: 9102697
    Abstract: The present invention relates to trioxacarcin compounds of the formula: (I) or pharmaceutically acceptable forms thereof; wherein R1, R2, R3, R4, R5, R6, R7, R8, and R9 are as defined herein. The present invention also provides processes for preparing such compounds and intermediates thereto; pharmaceutical compositions comprising such compounds; and methods of use and treatment.
    Type: Grant
    Filed: March 22, 2011
    Date of Patent: August 11, 2015
    Assignee: President and Fellows of Harvard College
    Inventors: Andrew G. Myers, Nicholas E. Hill, Jakub Svenda, Robert T. Yu, Daniel J. Smaltz, Thomas Magauer
  • TRIOXACARCINS AND USES THEREOF
    Publication number: 20130150314
    Abstract: The present invention relates to trioxacarcin compounds of the formula: (I) or pharmaceutically acceptable forms thereof; wherein R1, R2, R3, R4, R5, R6, R7, R8, and R9 are as defined herein. The present invention also provides processes for preparing such compounds and intermediates thereto; pharmaceutical compositions comprising such compounds; and methods of use and treatment.
    Type: Application
    Filed: March 22, 2011
    Publication date: June 13, 2013
    Applicant: President and Fellows of Harvard College
    Inventors: Andrew G. Myers, Nicholas E. Hill, Jakub Svenda, Robert T. Yu, Daniel J. Smaltz, Thomas Magauer