Patents by Inventor Nicholas E. S. Sibinga

Nicholas E. S. Sibinga has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Intracellular domain of a mammalian Fat1 (Fat1IC)
    Patent number: 8586534
    Abstract: Provided is an extracellular domain of a mammalian Fat1 (Fat1EC). Also provided is an intracellular domain of a mammalian Fat1 (Fat1IC). Additionally provided is a vector comprising a nucleic acid sequence encoding the Fat1EC. A vector comprising a nucleic acid sequence encoding the Fat1IC is further provided. Also, a vascular stent coated with the Fat1EC is provided. Further provided is a vascular stent coated with a Fat1 ligand that activates Fat1. A method of treating a patient at risk for restenosis of a blood vessel is additionally provided. Further, methods of treating an injured blood vessel in a patient is provided. A method of treating a patient at risk for restenosis of a blood vessel or having an injured blood vessel is also provided.
    Type: Grant
    Filed: April 25, 2008
    Date of Patent: November 19, 2013
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Nicholas E. S. Sibinga, Rong Hou
  • Methods and compositions for regulating proliferation and migration of vascular smooth muscle cells
    Publication number: 20090117169
    Abstract: Provided is an extracellular domain of a mammalian Fat1 (Fat1EC). Also provided is an intracellular domain of a mammalian Fat1 (Fat1IC). Additionally provided is a vector comprising a nucleic acid sequence encoding the Fat1EC. A vector comprising a nucleic acid sequence encoding the Fat1IC is further provided. Also, a vascular stent coated with the Fat1EC is provided. Further provided is a vascular stent coated with a Fat1 ligand that activates Fat1. A method of treating a patient at risk for restenosis of a blood vessel is additionally provided. Further, methods of treating an injured blood vessel in a patient is provided. A method of treating a patient at risk for restenosis of a blood vessel or having an injured blood vessel is also provided.
    Type: Application
    Filed: April 25, 2008
    Publication date: May 7, 2009
    Inventors: Nicholas E.S. Sibinga, Rong Hou
  • Cellular basis of vascular-graft stenosis
    Patent number: 6248933
    Abstract: A mouse model for vein graft stenosis useful for identifying compounds which reduce or prevent such stenosis, consisting of a mouse engrafted with an autogenous vein which exhibits detectable stenosis within 30 days of transplantation. Also disclosed are therapeutic methods for inhibiting the development of vein graft stenosis.
    Type: Grant
    Filed: November 6, 1998
    Date of Patent: June 19, 2001
    Assignee: President and Fellows of Harvard College
    Inventors: Edgar Haber, Chengwei Shi, Nicholas E. S. Sibinga