Patents by Inventor Nicholas Eakley

Nicholas Eakley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and Compositions for Making Amide Compounds
    Publication number: 20250305013
    Abstract: Disclosed are biosynthetic methods and engineered microorganisms that enhance or improve the biosynthesis of 6-aminocaproate, hexamethylenediamine, caproic acid, caprolactone, or caprolactam. The engineered microorganisms are modified to include, for example, upredulated and/or exogenous transporters for 6-aminocaproate, deletions and/or downregulated importers for 6-aminocaproate, upregulated and/or exogenous glutamate dehydrogenase, and/or deletions and/or downregulation of rcsA and/or cpsBG. Other engineered microorganisms may have disruptions of endogenous transporters for 6-aminocaproate.
    Type: Application
    Filed: January 15, 2022
    Publication date: October 2, 2025
    Applicant: Genomatica, Inc.
    Inventors: Harish Nagarajan, Tae Hoon Yang, Ali Khodayari, Shawn Bachan, Sankha Ghatak, Nicholas Eakley, Amit Shah, Jinel Shah, Bo Zhang
  • ENGINEERED MICROORGANISMS & METHODS FOR IMPROVED CROTYL ALCOHOL PRODUCTION
    Publication number: 20210277426
    Abstract: Disclosed are methods and engineered microorganisms that enhance or improve the production of crotyl alcohol. The engineered microorganisms include genetic modifications in alcohol dehydrogenase, alkene reductase or both enzymatic activities. By such genetic modifications, a crotyl alcohol production pathway is provided or improved.
    Type: Application
    Filed: November 19, 2020
    Publication date: September 9, 2021
    Inventors: Stephanie J. Culler, Nicholas Eakley, Kevin Gregory Hoff, Robin E. Osterhout, Priti Pharkya, Erik C. Ralph, Stephen J. Van Dien
  • Engineered microorgansims and methods for improved crotyl alcohol production
    Patent number: 10844404
    Abstract: Disclosed are methods and engineered microorganisms that enhance or improve the production of crotyl alcohol. The engineered microorganisms include genetic modifications in alcohol dehydrogenase, alkene reductase or both enzymatic activities. By such genetic modifications, a crotyl alcohol production pathway is provided or improved.
    Type: Grant
    Filed: April 7, 2016
    Date of Patent: November 24, 2020
    Assignee: Genomatica Inc.
    Inventors: Stephanie J. Culler, Nicholas Eakley, Kevin Gregory Hoff, Robin E. Osterhout, Priti Pharkya, Erik C. Ralph, Stephen Van Dien
  • ENGINEERED MICROORGANSIMS & METHODS FOR IMPROVED CROTYL ALCOHOL PRODUCTION
    Publication number: 20180135082
    Abstract: Disclosed are methods and engineered microorganisms that enhance or improve the production of crotyl alcohol. The engineered microorganisms include genetic modifications in alcohol dehydrogenase, alkene reductase or both enzymatic activities. By such genetic modifications, a crotyl alcohol production pathway is provided or improved.
    Type: Application
    Filed: April 7, 2016
    Publication date: May 17, 2018
    Applicant: GENOMATICA, iNC.
    Inventors: Stephanie J. Culler, Nicholas Eakley, Kevin Gregory Hoff, Robin E. Osterhout, Priti Pharkya, Erik C. Ralph, Stephen Van Dien