Abstract: The present invention relates to a single-board processor card configured for use in a 1U CubeSat payload form-factor multi-purpose architecture, including: a field-programmable-gate-array (FPGA) which is reconfigurable in flight; wherein a configuration memory of the FPGA can be scrubbed in flight to correct errors or upsets; and a radiation-hardened monitor (RHM) which provides radiation mitigation and system monitoring of the single-board processor card, and which reconfigures said FPGA during flight, scrubs the configuration memory, and monitors a health of the FPGA. The 1U CubeSat payload form-factor multi-purpose architecture includes a backplane having a plurality of slots, one of the plurality of slots which accommodates the single-board processor card, wherein the backplane routes signals to a plurality of standard-sized processor cards, interchangeably disposed in any of the plurality of slots.