Patents by Inventor Nicholas Frankel

Nicholas Frankel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250041345
    Abstract: Described herein are multicistronic expression systems that encode chimeric proteins, specifically membrane-cleavable chimeric systems and chimeric antigen receptors. Also described herein are nucleic acids, cells, and methods directed to the same.
    Type: Application
    Filed: October 21, 2024
    Publication date: February 6, 2025
    Inventors: Brian Scott Garrison, Michelle Elizabeth Hung, Nicholas Frankel, Han Deng, Gozde Yucel
  • Publication number: 20250011384
    Abstract: Provided herein are cytokine-immunoreceptor fusion proteins. Also provided herein are cells, polynucleotides, vectors, compositions, and methods directed to cytokine-immunoreceptor fusion proteins.
    Type: Application
    Filed: July 18, 2024
    Publication date: January 9, 2025
    Inventors: Aldo Omar Sotelo, Alba Gonzalez-Junca, Nicholas Frankel
  • Publication number: 20240173410
    Abstract: Provided herein are chimeric proteins comprising an antigen-binding domain specific for V-Set And Immunoglobulin Domain Containing 2 (VSIG2). Also provided herein are cells, polynucleotides, vectors, compositions, and methods directed to chimeric proteins comprising an antigen-binding domain specific for VSIG2.
    Type: Application
    Filed: November 7, 2023
    Publication date: May 30, 2024
    Inventors: Alba Gonzalez-Junca, Nicholas Frankel, Assen Boyanov Roguev
  • Publication number: 20240042027
    Abstract: Provided herein are solid tumor antigen targets for chimeric receptors and chimeric inhibitory receptors, and methods of using the same, such as for the treatment of cancer.
    Type: Application
    Filed: May 24, 2023
    Publication date: February 8, 2024
    Inventors: Brian Scott GARRISON, Alba GONZALEZ-JUNCA, Gary LEE, Assen Boyanov ROGUEV, Frances Deen LIU, Nicholas FRANKEL
  • Publication number: 20230372486
    Abstract: Provided herein are EMCN-specific antigen-binding domains, and chimeric proteins including the EMCN-specific antigen-binding. Also provided herein are cells, nucleic acids, vectors, compositions, and methods directed to proteins including the EMCN-specific antigen-binding domains.
    Type: Application
    Filed: April 14, 2023
    Publication date: November 23, 2023
    Inventors: Brian Scott GARRISON, Michelle Elizabeth HUNG, Nicholas FRANKEL
  • Publication number: 20230272037
    Abstract: Provided herein are inhibitory chimeric antigen receptor compositions and cells comprising such compositions. Also provided are methods of using inhibitory chimeric antigen receptors and cells.
    Type: Application
    Filed: August 18, 2022
    Publication date: August 31, 2023
    Inventors: Russell Morrison Gordley, Marcela Guzman Ayala, Gary Lee, Nicholas Frankel
  • Publication number: 20230235051
    Abstract: Provided herein are inhibitory chimeric antigen receptor compositions and cells comprising such compositions. Also provided are methods of using inhibitory chimeric antigen receptors and cells.
    Type: Application
    Filed: August 17, 2022
    Publication date: July 27, 2023
    Inventors: Wilson Wong, Seunghee Lee, Russell Morrison Gordley, Marcela Guzman Ayala, Gary Lee, Nicholas Frankel, Xi Kang
  • Publication number: 20220289842
    Abstract: Provided herein are chimeric inhibitory receptor constructs and compositions, and cells comprising the same. Also provided are methods of using chimeric inhibitory receptor constructs and compositions, and cells comprising the same.
    Type: Application
    Filed: August 20, 2020
    Publication date: September 15, 2022
    Inventors: Russell Morrison Gordley, Nicholas Frankel