Abstract: Systems and methods for treatment of squamous cell carcinoma or other cancer utilizing targeting peptides are described. The targeting peptides interact with SCC cells or other cancerous cells to block or interfere with 14-3-3? heterodimerization or CDC25A binding to 14-3-3?. A peptide composition embodiment includes, but is not limited to, at least one of a first targeting peptide comprising a structure of Trp-Tyr-Trp-Lys-NH2 (SEQ ID NO: 1), a second targeting peptide comprising a structure of phospho-Ser178; Ac-Thr-Gln-Arg-Gln-Asn-Ser-(PO32?)-Ala-Pro-Arg-Met-Leu-Ser-Ser-Asn-NH2 (SEQ ID NO: 2), and a third targeting peptide comprising a structure of phospho-Thr507 residue; Ac-Arg-Thr-Lys-Ser-Arg-Thr(PO32?)-Trp-Ala-Gly-Glu-Lys-Ser-Lys-Arg-NH2 (SEQ ID NO: 3).

Abstract: Methods, systems, and media for coordinating multiplayer game sessions are provided.

Abstract: A surface cleaner that includes an accessory body removably coupled to a base. A nozzle has a first nozzle portion having a first nozzle passageway attached to the base and a second nozzle portion having a second nozzle passageway attached to the accessory body and removable with the accessory body. The first nozzle portion and second nozzle portion are releasably coupled connecting the first and second nozzle passageways along an airpath in fluid communication with a collection container when the accessory body is coupled to the base. The first nozzle passageway forms a suction inlet when the accessory body is coupled to the base and the second nozzle passageway forms the suction inlet in communication with the collection container and the suction source when the accessory body is uncoupled from the base.

Abstract: Rolling engine start-stop (RESS) system and methods for a vehicle include a set of sensors configured to measure a set of operating parameters of the vehicle comprising at least (i) driver input via brake pedal of the vehicle, (ii) vehicle speed, and (iii) a steering angle of the vehicle and a controller configured to, based on the set of operating parameters, determine a target vehicle speed for stopping an engine of the vehicle, and based on the steering angle of the vehicle, selectively stopping the engine of the vehicle when the vehicle speed falls to the determined target vehicle speed, wherein stopping the engine of the vehicle at the determined target vehicle speed decreases noise/vibration/harshness (NVH) caused by stopping the engine.

Abstract: In a system including a beverage preparation machine and a compatible steam wand (11), the machine has a wand holder (1) for releasably mounting the wand and a source of steam. The machine includes a steam nozzle (23) engageable with the wand and mounted for movement between an operative position in which it is fluidly connected with the source of steam and a rest position in which it is fluidly isolated from the source of steam. The nozzle is biased to the rest position. When the nozzle is in its rest position it can be at least partially engaged with the wand before the wand is fully inserted in the holder. The arrangement such that the steam nozzle (23) is moved to the operative position on insertion of the wand fully into the holder.

Abstract: The invention provides a beverage preparation machine comprising a steam wand connector wherein the connector comprises an aperture having a first portion having a first maximum width which tapers and/or curves to a second portion which has a second narrower width.

Abstract: A system, method, apparatus, and computer program product for enabling management of a converged infrastructure are disclosed. A method may include determining components of the converged infrastructure whose configurations need to be modified in order to modify the configuration of the converged infrastructure in accordance with a received command to modify the configuration of the converged infrastructure. The method may also include modifying the configuration of each of the determined components to modify the configuration of the converged infrastructure in accordance with the received command.

Abstract: The present invention provides a method of assembling a filter element (8) with a cup-shaped capsule body (2) using a combined weld-head (70) and former (80), comprising the steps of positioning the filter element (8) at or near a mouth of the cup-shaped capsule body (2), moving the combined weld-head (70) and former (80) so as to contact and drive the filter element (8) into the cup-shaped capsule body (2), wherein, the filter element (8) is deformed by a sprung-loaded former (80) of the combined weld-head (70) and former (80) to form a cup-shaped filter element (56), and using a weld-head (70) of the combined weld-head (70) and former (80) to bond the cup-shaped filter element (56) to the cup-shaped capsule body (2). The present invention further provides a method of making a beverage capsule and a beverage capsule produced using this method.

Abstract: A beverage preparation machine configured to dispense a beverage through an outlet nozzle assembly, the machine comprising: an outlet nozzle assembly having provided therethrough a first outlet and a second outlet; and one or more conduits arranged to deliver selectably fluid to the first outlet or the second outlet.

Abstract: A customer support technique for an electronic system includes operating a computerized apparatus to conduct a video chat with a remote customer support device. During the course of the video chat, the computerized apparatus simultaneously exchanges information pertaining to the electronic system. The computerized apparatus collects diagnostic information from the electronic system, transmits the diagnostic information to the customer support device, and receives remedial information back from the customer support device, all while the video chat continues to proceed without interruption. The improved technique thus provides a near-hands-on support experience from a remote customer support agent regardless of the customer support agent's physical location.

Abstract: A resource authorization system includes an authorization routing service that is executed on a computing device to authenticate a client to form a client login session, and to receive, from the client, a request to establish a connection to one or more of the resources of a distributed computing system. The authorization routing service then obtains a list of the resources associated with the client login session in which the list of resources includes those that the client is authorized to communicate with. When the requested resource is included in the list of resources, the authorization routing service authenticates the requested resources to form a resource login session, and establish the connection by communicatively coupling the client login session and the resource login session. The resource login session is established independently of the client login session.

Abstract: A snowshoe provides a way for outdoor enthusiasts to traverse the backcountry effectively and efficiently. The snowshoe allows the user to glide through the snow like a cross-country ski, but with the minimal footprint of a traditional snowshoe. The snowshoe includes a board and a binding mechanism that secures the user to the board, but allows for a pivoting motion. The pivoting motion allows the user to ascend steep terrain by performing a motion similar to cross-country skiing.

Abstract: A system, method, and computer program product for testing a software component by simulating an interface to a computing component using pseudo-randomized responses to service requests. For example, the method may include receiving a service request from a software component to be tested. Responsive to receiving the service request from the software component, the method accesses a data store of service requests and responses thereto. The method determines that a matching service request is stored in the accessed data, a matching service request being a service request that matches the service request received from the software component. The method identifies a plurality of associated responses that are stored in the accessed data store, each which is stored in association with the matching service request. The method pseudo-randomly selects one of the plurality of associated responses, and sends the pseudo-randomly selected associated response to the software component for processing.

Abstract: The present invention provides a method of assembling a filter element (8) with a cup-shaped capsule body (2) using a combined weld-head (70) and former (80), comprising the steps of positioning the filter element (8) at or near a mouth of the cup-shaped capsule body (2), moving the combined weld-head (70) and former (80) so as to contact and drive the filter element (8) into the cup-shaped capsule body (2), wherein, the filter element (8) is deformed by a sprung-loaded former (80) of the combined weld-head (70) and former (80) to form a cup-shaped filter element (56), and using a weld-head (70) of the combined weld-head (70) and former (80) to bond the cup-shaped filter element (56) to the cup-shaped capsule body (2). The present invention further provides a method of making a beverage capsule and a beverage capsule produced using this method.

Abstract: A beverage preparation machine configured to dispense a beverage through an outlet nozzle assembly, the machine comprising: an outlet nozzle assembly having provided therethrough a first outlet and a second outlet; and one or more conduits arranged to deliver selectably fluid to the first outlet or the second outlet.

Abstract: The present invention provides a method of assembling a filter element (8) with a cup-shaped capsule body (2) using a combined weld-head (70) and former (80), comprising the steps of positioning the filter element (8) at or near a mouth of the cup-shaped capsule body (2), moving the combined weld-head (70) and former (80) so as to contact and drive the filter element (8) into the cup-shaped capsule body (2), wherein, the filter element (8) is deformed by a sprung-loaded former (80) of the combined weld-head (70) and former (80) to form a cup-shaped filter element (56), and using a weld-head (70) of the combined weld-head (70) and former (80) to bond the cup-shaped filter element (56) to the cup-shaped capsule body (2). The present invention further provides a method of making a beverage capsule and a beverage capsule produced using this method.

Abstract: A system, method, and computer program product for testing a software component by simulating a computing component interface using captured network packet information. A method may include receiving a service request comprised of one or more network packets from a software component to be tested. Responsive to receiving the service request, the method may access a data store of captured network packet information and determine that a matching service request is stored in the accessed data store. The matching service request may be comprised of one or more network packets that match the service request. The method may identify an associated response that is stored in the accessed data store. The associated response may be one or more network packets that are stored in association with the matching service request. The method then sends the associated response to the first software component.

Abstract: A beverage preparation machine configured to dispense a beverage through an outlet nozzle assembly, the machine comprising: an outlet nozzle assembly having provided therethrough a first outlet and a second outlet; and one or more conduits arranged to deliver selectably fluid to the first outlet or the second outlet.

Abstract: A snowshoe provides a way for outdoor enthusiasts to traverse the backcountry effectively and efficiently. The snowshoe allows the user to glide through the snow like a cross-country ski, but with the minimal footprint of a traditional snowshoe. The snowshoe includes a board and a binding mechanism that secures the user to the board, but allows for a pivoting motion. The pivoting motion allows the user to ascend steep terrain by performing a motion similar to cross-country skiing.