Patents by Inventor Nicholas J. Baumhover

Nicholas J. Baumhover has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • POLYACRIDINE NUCLEIC ACID DELIVERY PEPTIDE COMPLEXES
    Publication number: 20120035320
    Abstract: The present invention provides nucleic acid delivery polyplex complexes and anionic open polyplexes comprising a nucleic acid molecule reversibly bound to one or more of nucleic acid delivery polyplex complexes.
    Type: Application
    Filed: April 4, 2011
    Publication date: February 9, 2012
    Applicant: University of Iowa Research Foundation
    Inventors: Kevin G. Rice, Nicholas J. Baumhover, Christian A. Fernandez, Kevin Anderson, Mark D. Ericson, Jason T. Duskey, Koby Kizzire, Sanjib Khargharia, Samuel T. Crowley
  • Compositions and methods for nucleic acid delivery
    Patent number: 7795380
    Abstract: Compositions and methods are described for non-viral nucleic acid delivery. A targeting peptide capable of mediating targeting to a cell or subcellular compartment is derivatized with a photoaffinity label. Following an ionic interaction with a polynucleotide, such as DNA, and photolysis, the bioactive peptide becomes covalently attached to the DNA. Upon contact with a cell, the peptide facilities uptake of the peptide-polynucleotide conjugate into the cell or subcellular compartment. Methods for using this system for delivery of structural genes, including reporter genes, and detection of expression using bioluminescence are also described.
    Type: Grant
    Filed: June 4, 2007
    Date of Patent: September 14, 2010
    Assignee: University of Iowa Research Foundation
    Inventors: Kevin G. Rice, Garrett R. Rettig, Nicholas J. Baumhover
  • COMPOSITIONS AND METHODS FOR NUCLEIC ACID DELIVERY
    Publication number: 20080213898
    Abstract: Compositions and methods are described for non-viral nucleic acid delivery. A targeting peptide capable of mediating targeting to a cell or subcellular compartment is derivatized with a photoaffinity label. Following an ionic interaction with a polynucleotide, such as DNA, and photolysis, the bioactive peptide becomes covalently attached to the DNA. Upon contact with a cell, the peptide facilities uptake of the peptide-polynucleotide conjugate into the cell or subcellular compartment. Methods for using this system for delivery of structural genes, including reporter genes, and detection of expression using bioluminescence are also described.
    Type: Application
    Filed: June 4, 2007
    Publication date: September 4, 2008
    Inventors: Kevin G. Rice, Garrett R. Rettig, Nicholas J. Baumhover