Patents by Inventor Nicholas J. Hand

Nicholas J. Hand has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR TREATING PULMONARY ARTERIAL HYPERTENSION (PAH) AND OTHER DISORDERS
    Publication number: 20240110190
    Abstract: Compositions and methods for treating fibrosis using oligonucleotide-based therapies are provided. These therapies can be used to increase expression of Bone morphogenetic protein receptor type II (BMPR2) via inhibition of upstream Open Reading Frames, thereby reducing vasoconstriction, vascular remodeling, and formation of fibrosis, particularly pulmonary arterial fibrosis related in patients in need thereof.
    Type: Application
    Filed: February 28, 2022
    Publication date: April 4, 2024
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Yoseph BARASH, David Sheng Ming LEE, Louis R. GHANEM, Nicholas J. HAND
  • Compositions and methods for treating liver injury
    Patent number: 9932583
    Abstract: Compositions and methods for detecting, inhibiting, treating, and/or preventing a liver disease or disorder such as cholestasis or fibrotic liver disease are provided.
    Type: Grant
    Filed: February 17, 2015
    Date of Patent: April 3, 2018
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Joshua R. Friedman, Nicholas J. Hand
  • Compositions and Methods for Treating Liver Injury
    Publication number: 20160355812
    Abstract: Compositions and methods for detecting, inhibiting, treating, and/or preventing a liver disease or disorder such as cholestasis or fibrotic liver disease are provided.
    Type: Application
    Filed: February 17, 2015
    Publication date: December 8, 2016
    Inventors: Joshua R. Friedman, Nicholas J. Hand