Patents by Inventor Nicholas J. MacDonald

Nicholas J. MacDonald has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Angiostatin and endostatin binding proteins and methods of use
    Publication number: 20020077289
    Abstract: The present invention is related to compositions and methods for the modulation of angiogenesis. In particular, the present invention includes Angiostatin and Endostatin binding peptides and proteins and methods of using the same. The present invention identifies tropomyosin protein as an Endostatin binding protein and a laminin beta-1 chain as an Angiostatin binding protein. The present invention also provides methods of inhibiting angiogenesis in an individual comprising administering to the individual a tropomyosin binding compound and/or an actin cytoskeleton disrupting compound.
    Type: Application
    Filed: June 4, 2001
    Publication date: June 20, 2002
    Inventors: Nicholas J. MacDonald, Kim L. Sim, John W. Holaday
  • Angiogenesis—inhibiting protein binding peptides and proteins and methods of use
    Patent number: 6201104
    Abstract: The present invention relates to peptides and proteins such as receptors that bind angiogenesis-related proteins ANGIOSTATIN™ protein or ENDOSTATIN™ protein. Peptides and proteins of the present invention can be isolated from body fluids including blood or urine, or can be synthesized by recombinant, enzymatic or chemical methods. The peptides are particularly important for identifying receptors of angiogenesis-related proteins, as well as for identifying other proteins that regulate, transport and otherwise interact with angiogenesis-related proteins.
    Type: Grant
    Filed: December 4, 1998
    Date of Patent: March 13, 2001
    Assignee: EntreMed, Inc.
    Inventors: Nicholas J. MacDonald, Kim Lee Sim