Patents by Inventor Nicholas J. Machesky

Nicholas J. Machesky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cell-based assay using electrophysiological activity measured with microelectrode arrays
    Patent number: 11740230
    Abstract: Methods for detecting and/or quantifying the potency of an agent using a cell-based assay are disclosed. A mammalian cell culture is grown upon a microelectrode array (MEA) which is used to measure an electrophysiological response of the mammalian cell culture. The cell culture is exposed to the agent, generally in at least two different dosages. The potency of the agent is detected by measuring a change in the electrophysiological responses associated with the at least two dosages when compared to a control condition. These changes can include the weighted mean firing rate (wMFR) and bursting of the cells.
    Type: Grant
    Filed: March 9, 2020
    Date of Patent: August 29, 2023
    Assignee: Batelle Memorial Institute
    Inventor: Nicholas J. Machesky
  • CELL-BASED ASSAY USING ELECTROPHYSIOLOGICAL ACTIVITY MEASURED WITH MICROELECTRODE ARRAYS
    Publication number: 20200292530
    Abstract: Methods for detecting and/or quantifying the potency of an agent using a cell-based assay are disclosed. A mammalian cell culture is grown upon a microelectrode array (MEA) which is used to measure an electrophysiological response of the mammalian cell culture. The cell culture is exposed to the agent, generally in at least two different dosages. The potency of the agent is detected by measuring a change in the electrophysiological responses associated with the at least two dosages when compared to a control condition. These changes can include the weighted mean firing rate (wMFR) and bursting of the cells.
    Type: Application
    Filed: March 9, 2020
    Publication date: September 17, 2020
    Inventor: Nicholas J. Machesky