Patents by Inventor Nicholas J. Manesis

Nicholas J. Manesis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250114187
    Abstract: A prosthesis can include a shell and a needle guard coupled to a posterior portion of the shell. The shell can include a laminate having a base layer, a top layer, and a soft silicone gel intermediate layer disposed between the base layer and the top layer and of sufficient thickness for self-sealing of a needle hole therethrough. The needle guard can include a plurality of offset layers of offset, puncture-resistance structures that, in an expanded state, (i) collectively form a concave shape and (ii) provide a concave exterior surface along the posterior portion of the prosthesis for approximating a human anatomical feature. The needle guard can have a shape memory characteristic for urging the prosthesis toward the expanded state.
    Type: Application
    Filed: August 12, 2024
    Publication date: April 10, 2025
    Inventors: Kaustubh S. Chitre, Nicholas J. Manesis, Nikhil S. Trilokekar, Dustin Leslie, David John Schuessler
  • Publication number: 20240366490
    Abstract: Compositions useful as dermal fillers and methods using such compositions to treat various skin and soft tissue conditions. The dermal fillers can comprise silk attached to hyaluronic acid using for example two cross linkers and can be used to treat of facial imperfections, facial defects, facial augmentations, breast imperfections, breast augmentations or breast reconstructions.
    Type: Application
    Filed: December 18, 2023
    Publication date: November 7, 2024
    Inventors: Elizabeta Pavlovic, Monica A. Serban, Xiaojie Yu, Nicholas J. Manesis
  • Publication number: 20240350706
    Abstract: Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.
    Type: Application
    Filed: December 4, 2023
    Publication date: October 24, 2024
    Inventors: Xiaojie Yu, Nicholas J. Manesis, Jacob Pollock
  • Publication number: 20240342072
    Abstract: The present invention provides highly injectable, long-lasting hyaluronic acid-based hydrogel dermal filler compositions made with a di-amine or multiamine crosslinker in the presence of a carbodiimide coupling agent.
    Type: Application
    Filed: February 20, 2024
    Publication date: October 17, 2024
    Inventors: Gabriel N. Njikang, Xiaojie Yu, Futian Liu, Nicholas J. Manesis
  • Patent number: 11833269
    Abstract: Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.
    Type: Grant
    Filed: October 8, 2019
    Date of Patent: December 5, 2023
    Assignee: Allergan, Inc.
    Inventors: Xiaojie Yu, Nicholas J. Manesis, Jacob Pollock
  • Publication number: 20230310700
    Abstract: Provided are injectable, hyaluronic acid-based hydrogel compositions including conjugated vitamins.
    Type: Application
    Filed: November 11, 2022
    Publication date: October 5, 2023
    Inventors: Futian Liu, Xiaojie Yu, Nicholas J. Manesis, Athene Wan Chie Chan
  • Patent number: 11692075
    Abstract: Methods and materials used for production of constructs having a porous open or semi-open celled structure. Constructs may include a porous matrix as a base and a biocompatible conformal coating thereon.
    Type: Grant
    Filed: October 19, 2021
    Date of Patent: July 4, 2023
    Assignee: Poragen LLC
    Inventors: Nicholas J. Manesis, Dylan B. Hollrigel
  • Publication number: 20220273422
    Abstract: A corneal inlay device comprising a flat or flat-like base and a dome or droplet top. The corneal inlay can be used to treat, for example without limitation, presbyopia, while reducing or eliminating the risk of a patient developing corneal haze.
    Type: Application
    Filed: July 30, 2020
    Publication date: September 1, 2022
    Inventors: Nicholas J. Manesis, Phihoa Tran-Hata, Alan Le, Khanh Nguyen
  • Publication number: 20220023186
    Abstract: The present invention provides highly injectable, long-lasting hyaluronic acid-based hydrogel dermal filler compositions made with a di-amine or multiamine crosslinker in the presence of a carbodiimide coupling agent.
    Type: Application
    Filed: August 6, 2021
    Publication date: January 27, 2022
    Inventors: Gabriel N. Njikang, Xiaojie Yu, Futian Liu, Nicholas J. Manesis
  • Patent number: 11202853
    Abstract: The present specification discloses porogen compositions comprising a core material and shell material, methods of making such porogen compositions, methods of forming such porous materials using such porogen compositions, biocompatible implantable devices comprising such porous materials, and methods of making such biocompatible implantable devices.
    Type: Grant
    Filed: April 16, 2020
    Date of Patent: December 21, 2021
    Assignee: Allergan, Inc.
    Inventors: Futian Liu, Nicholas J Manesis, Xiaojie Yu, Athene W. Chan
  • Patent number: 11149127
    Abstract: Methods and materials used for production of constructs having a porous open or semi-open celled structure. Constructs may include a porous matrix as a base and a biocompatible conformal coating thereon.
    Type: Grant
    Filed: March 26, 2021
    Date of Patent: October 19, 2021
    Assignee: Poragen LLC
    Inventors: Nicholas J. Manesis, Dylan B. Hollrigel
  • Patent number: 11083684
    Abstract: The present invention provides highly injectable, long-lasting hyaluronic acid-based hydrogel dermal filler compositions made with a di-amine or multiamine crosslinker in the presence of a carbodiimide coupling agent.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: August 10, 2021
    Assignee: ALLERGAN INDUSTRIE, SAS
    Inventors: Gabriel N. Njikang, Xiaojie Yu, Futian Liu, Nicholas J. Manesis
  • Patent number: 11000626
    Abstract: Provided are injectable, hyaluronic acid-based dermal filler compositions including conjugated vitamin C derivatives. The compositions provide for extended release of active vitamin C into tissue, promoting collagenesis and other benefits to skin.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: May 11, 2021
    Assignee: ALLERGAN INDUSTRIE, SAS
    Inventors: Futian Liu, Xiaojie Yu, Jessamine P. Winer-Jones, Nicholas J. Manesis, Hengli Liu, Gabriel Njikang, Athene Wan Chie Chan
  • Patent number: 10994049
    Abstract: The present invention provides highly injectable, long-lasting hyaluronic acid-based hydrogel dermal filler compositions which are particularly advantageous for correction of fine lines in the face.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: May 4, 2021
    Assignee: ALLERGAN INDUSTRIE, SAS
    Inventors: Gabriel N. Njikang, Xiaojie Yu, Futian Liu, Sumit Paliwal, Nicholas J. Manesis
  • Patent number: 10758470
    Abstract: Compositions useful as dermal fillers and methods using such compositions to treat various skin and soft tissue conditions. The dermal fillers can comprise silk attached to hyaluronic acid using for example two cross linkers and can be used to treat of facial imperfections, facial defects, facial augmentations, breast imperfections, breast augmentations or breast reconstructions.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: September 1, 2020
    Assignee: ALLERGAN, INC.
    Inventors: Elizabeta Pavlovic, Monica A. Serban, Xiaojie Yu, Nicholas J. Manesis
  • Publication number: 20200237968
    Abstract: The present specification discloses porogen compositions comprising a core material and shell material, methods of making such porogen compositions, methods of forming such porous materials using such porogen compositions, biocompatible implantable devices comprising such porous materials, and methods of making such biocompatible implantable devices.
    Type: Application
    Filed: April 16, 2020
    Publication date: July 30, 2020
    Inventors: Futian Liu, Nicholas J. Manesis, Xiaojie Yu, Athene W. Chan
  • Publication number: 20200139006
    Abstract: Dermal filler compositions presented herein can contain a vitamin that is conjugated to a hyaluronic acid.
    Type: Application
    Filed: January 6, 2020
    Publication date: May 7, 2020
    Inventors: Futian Liu, Xiaojie Yu, Nicholas J. Manesis, Athene Wan Chie Chan
  • Patent number: 10624988
    Abstract: Provided are injectable, hyaluronic acid-based hydrogel compositions including conjugated vitamins.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: April 21, 2020
    Assignee: Allergan Industrie, SAS
    Inventors: Futian Liu, Xiaojie Yu, Nicholas J. Manesis, Athene Wan Chie Chan
  • Patent number: 10624997
    Abstract: The present specification discloses porogen compositions comprising a core material and shell material, methods of making such porogen compositions, methods of forming such porous materials using such porogen compositions, biocompatible implantable devices comprising such porous materials, and methods of making such biocompatible implantable devices.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: April 21, 2020
    Assignee: Allergan, Inc.
    Inventors: Futian Liu, Nicholas J. Manesis, Xiaojie Yu, Athene W. Chan
  • Publication number: 20200038550
    Abstract: The present specification discloses porous materials, methods of forming such porous materials, biocompatible implantable devices that include such porous materials, and methods of making such biocompatible implantable devices.
    Type: Application
    Filed: July 19, 2019
    Publication date: February 6, 2020
    Inventors: Futian Liu, Nicholas J. Manesis, Alexei Goraltchouk, Dimitri Stroumpoulis