Patents by Inventor Nicholas J. P. Ryba

Nicholas J. P. Ryba has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mammalian sweet and amino acid heterodimeric taste receptors comprising T1R3 and T1R1
    Patent number: 9347935
    Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising T1R3 and T1R1, two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.
    Type: Grant
    Filed: May 28, 2013
    Date of Patent: May 24, 2016
    Assignees: The Regents of the University of California, The United States of America as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Charles S. Zuker, Jayaram Chandrashekar, Greg Nelson, Yifeng Zhang, Nicholas J. P. Ryba, Mark A. Hoon
  • Mammalian Sweet and Amino Acid Heterodimeric Taste Receptors Comprising T1R3 and T1R1
    Publication number: 20140024043
    Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising T1R3 and T1R1, two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.
    Type: Application
    Filed: May 28, 2013
    Publication date: January 23, 2014
    Applicant: The Regents of the University of California
    Inventors: Charles S. Zuker, Jayaram Chandrashekar, Greg Nelson, Yifeng Zhang, Nicholas J. P. Ryba, Mark A. Hoon
  • Mammalian sweet and amino acid heterodimeric taste receptors comprising T1R3 and T1R1
    Patent number: 8470970
    Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising T1R3 and T1R1, two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.
    Type: Grant
    Filed: November 11, 2010
    Date of Patent: June 25, 2013
    Assignees: The Regents of the University of California, The Government of the United States of America
    Inventors: Charles S. Zuker, Jayaram Chandrashekar, Greg Nelson, Yifeng Zhang, Nicholas J. P. Ryba, Mark A. Hoon
  • Mammalian sweet taste receptors
    Patent number: 8198048
    Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.
    Type: Grant
    Filed: March 10, 2010
    Date of Patent: June 12, 2012
    Assignees: The Regents of the University of California, The United States of America as represented by the Department of Health and Human Services
    Inventors: Charles S. Zuker, Nicholas J. P. Ryba, Gregory A. Nelson, Mark A. Hoon, Jayaram Chandrashekar, Yifeng Zhang
  • Mammalian Sweet Taste Receptors
    Publication number: 20110244514
    Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.
    Type: Application
    Filed: March 10, 2010
    Publication date: October 6, 2011
    Inventors: Charles S. Zuker, Nicholas J.P. Ryba, Gregory A. Nelson, Mark A. Hoon, Jayaram Chandrashekar, Yifeng Zhang
  • Mammalian sweet taste receptors
    Patent number: 7977060
    Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.
    Type: Grant
    Filed: June 26, 2008
    Date of Patent: July 12, 2011
    Assignees: Regents of the University of California, The United States of America as represented by NIH
    Inventors: Charles S. Zuker, Nicholas J. P. Ryba, Gregory A. Nelson, Mark A. Hoon, Jayaram Chandrashekar, Yifeng Zhang
  • Mammalian Sweet and Amino Acid Heterodimeric Taste Receptors Comprising T1R3 and T1R1
    Publication number: 20110151483
    Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising T1R3 and T1R1, two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.
    Type: Application
    Filed: November 11, 2010
    Publication date: June 23, 2011
    Inventors: Charles S. Zuker, Jayaram Chandrashekar, Greg Nelson, Yifeng Zhang, Nicholas J. P. Ryba, Mark A. Hoon
  • Mammalian T1R3 sweet taste receptors
    Patent number: 7939279
    Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors, the receptors comprising consisting of a monomer or homodimer of a T1R3 G-protein coupled receptor polypeptide, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.
    Type: Grant
    Filed: October 23, 2008
    Date of Patent: May 10, 2011
    Assignees: The Regents of the University of California, The Department of Health and Human Services
    Inventors: Charles S Zuker, Nicholas J. P. Ryba, Isolde Erlenbach, Grace Q Zhao
  • Mammalian sweet and amino acid heterodimeric taste receptors comprising T1R3 and T1R1
    Patent number: 7842786
    Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising T1R3 and T1R1, two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.
    Type: Grant
    Filed: May 15, 2008
    Date of Patent: November 30, 2010
    Assignees: Regents of the University of California, United States of America, NIH
    Inventors: Charles S Zuker, Nicholas J. P. Ryba, Jayaram Chandrashekar, Mark A Hoon, Yifeng Zhang, Gregory A Nelson
  • Mammalian sweet and amino acid heterodimeric taste receptors
    Patent number: 7588900
    Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.
    Type: Grant
    Filed: July 3, 2002
    Date of Patent: September 15, 2009
    Assignees: The Regents of the University of California, The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Charles S Zuker, Nicholas J. P. Ryba, Jayaram Chandrashekar, Mark A Hoon, Yifeng Zhang, Greg Nelson
  • Mammalian T1R3 Sweet Taste Receptors
    Publication number: 20090155819
    Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors, the receptors comprising consisting of a monomer or homodimer of a T1R3 G-protein coupled receptor polypeptide, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.
    Type: Application
    Filed: October 23, 2008
    Publication date: June 18, 2009
    Inventors: Isolde Erlenbach, Nicholas J.P. Ryba, Grace Zhao, Charles S. Zuker
  • MAMMALIAN SWEET TASTE RECEPTORS
    Publication number: 20090098580
    Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.
    Type: Application
    Filed: June 26, 2008
    Publication date: April 16, 2009
    Inventors: Charles S. Zuker, Nicholas J.P. Ryba, Gregory A. Nelson, Mark A. Hoon, Jayaram Chandrashekar, Yifeng Zhang
  • Mammalian sweet taste receptors t1r3
    Patent number: 7507793
    Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.
    Type: Grant
    Filed: August 20, 2003
    Date of Patent: March 24, 2009
    Assignees: The Regents of the University of California, United States of America Dept. of Health and Human Services National Institutes of Health-OTT
    Inventors: Charles S. Zuker, Nicholas J. P. Ryba, Gregory A. Nelson, Mark A. Hoon, Jayaram Chandrashekar, Yifeng Zhang
  • Mammalian Sweet And Amino Acid Heterodimeric Taste Receptors
    Publication number: 20080318251
    Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.
    Type: Application
    Filed: May 15, 2008
    Publication date: December 25, 2008
    Inventors: Charles S. Zuker, Jayaram Chandrashekar, Greg Nelson, Yifeng Zhang, Nicholas J.P. Ryba, Mark A. Hoon
  • Method for screening taste-modulating compounds
    Patent number: 7465550
    Abstract: The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste transduction G-protein coupled receptors.
    Type: Grant
    Filed: October 7, 2004
    Date of Patent: December 16, 2008
    Assignees: The Regents of the University of California, The United States of America as represented by the Department of Health and Human Services
    Inventors: Charles S. Zuker, Jon Elliot Adler, Nicholas J.P. Ryba, Ken Mueller, Mark Hoon
  • Mammalian T1R3 sweet taste receptors
    Patent number: 7459277
    Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors, the receptors comprising consisting of a monomer or homodimer of a T1R3 G-protein coupled receptor polypeptide, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.
    Type: Grant
    Filed: April 10, 2006
    Date of Patent: December 2, 2008
    Assignees: The Regents of the University of California, The United States of America as represented by the Department of Health and Human Services
    Inventors: Isolde Erlenbach, Nicholas J. P. Ryba, Grace Zhao, Charles S. Zuker
  • Mammalian sweet taste receptors
    Patent number: 7402400
    Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.
    Type: Grant
    Filed: August 10, 2001
    Date of Patent: July 22, 2008
    Assignees: Regents of the University of California, The United States of America Department of Health and Human Services
    Inventors: Charles S. Zuker, Nicholas J. P. Ryba, Gregory A. Nelson, Mark A. Hoon, Jayaram Chandrashekar, Yifeng Zhang
  • Mammalian sweet and amino acid heterodimeric taste receptors
    Publication number: 20030166137
    Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.
    Type: Application
    Filed: July 3, 2002
    Publication date: September 4, 2003
    Applicant: The Regents of the University of California
    Inventors: Charles S. Zuker, Jayaram Chandrashekar, Greg Nelson, Yifeng Zhang, Nicholas J.P. Ryba, Mark A. Hoon
  • Mammalian sweet taste receptors
    Publication number: 20030040045
    Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.
    Type: Application
    Filed: August 10, 2001
    Publication date: February 27, 2003
    Applicant: The Regents of the University of California
    Inventors: Charles S. Zuker, Gregory A. Nelson, Jayaram Chandrashekar, Yifeng Zhang, Nicholas J.P. Ryba, Mark A. Hoon