Patents by Inventor Nicholas J. Turro

Nicholas J. Turro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of four-color 3?-O-allyl modified photocleavable fluorescent nucleotides and related methods
    Patent number: 10907194
    Abstract: This invention provides a process for making 3?-O-allyl-dGTP-PC-Biodopy-FL-510, 3?-O-allyl-dATP-PC-ROX, 3?-O-allyl-dCTP-PC-Bodipy-650 and 3?-O-allyl-dUTP-PC-R6G, and related methods.
    Type: Grant
    Filed: January 11, 2016
    Date of Patent: February 2, 2021
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Jingyue Ju, Qinglin Meng, Dae H Kim, Lanrong Bi, Xiaopeng Bai, Nicholas J Turro
  • Photochemical methods and photoactive compounds for modifying surfaces
    Patent number: 9454077
    Abstract: Compounds and methods for controlling the surface properties are described. Compounds of the invention can form radicals upon exposure to irradiation, which can then react with nearby molecules to alter the surface properties of various substrates. The invention can provide surfaces that are resistant to dewetting, surfaces that have immobilized molecules such as carbohydrates and polymers immobilized, and surfaces that have metals deposited on the surface. The invention can be utilized in a wide range of application, such as sensors, microreactors, microarrays, electroless deposition of metals, and the like.
    Type: Grant
    Filed: January 5, 2015
    Date of Patent: September 27, 2016
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Gregory T. Carroll, Jeffrey T. Koberstein, Denong Wang, Nicholas J. Turro
  • Photochemical Methods and Photoactive Compounds for Modifying Surfaces
    Publication number: 20160231649
    Abstract: Compounds and methods for controlling the surface properties are described. Compounds of the invention can form radicals upon exposure to irradiation, which can then react with nearby molecules to alter the surface properties of various substrates. The invention can provide surfaces that are resistant to dewetting, surfaces that have immobilized molecules such as carbohydrates and polymers immobilized, and surfaces that have metals deposited on the surface. The invention can be utilized in a wide range of application, such as sensors, microreactors, microarrays, electroless deposition of metals, and the like.
    Type: Application
    Filed: January 5, 2015
    Publication date: August 11, 2016
    Inventors: Gregory T. CARROLL, Jeffrey T. KOBERSTEIN, Denong WANG, Nicholas J. TURRO
  • SYNTHESIS OF FOUR-COLOR 3'-O-ALLYL MODIFIED PHOTOCLEAVABLE FLUORESCENT NUCLEOTIDES AND RELATED METHODS
    Publication number: 20160208313
    Abstract: This invention provides a process for making 3?-O-allyl-dGTP-PC-Biodopy-FL-510, 3?-O-allyl-dATP-PC-ROX, 3?-O-allyl-dCTP-PC-Bodipy-650 and 3?-O-allyl-dUTP-PC-R6G, and related methods.
    Type: Application
    Filed: January 11, 2016
    Publication date: July 21, 2016
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Jingyue Ju, Qinglin Meng, Dae H Kim, Lanrong Bi, Xiaopeng Bai, Nicholas J Turro
  • Modification of surfaces with nanoparticles
    Patent number: 9296870
    Abstract: Methods for functionalizing a surface of a substrate with nanoparticles are described. In certain embodiments, the method can include attaching a plurality of photoactive linker to nanoparticles to obtain photoactive nanoparticles, wherein each photoactive linker comprises a binding group that attaches to the nanoparticles and a photoactive group; depositing the photoactive nanoparticles to the surface of the substrate, wherein the surface of the substrate comprises reactive groups that are capable of reacting with the photoactive groups; and irradiating the photoactive nanoparticles with radiation to react the photoactive group with the reactive group and to functionalize the surface of the substrate with nanoparticles.
    Type: Grant
    Filed: July 27, 2010
    Date of Patent: March 29, 2016
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Ellane J. Park, Nicholas J. Turro, Jeffrey T. Koberstein
  • Synthesis of four-color 3?-O-allyl modified photocleavable fluorescent nucleotides and related methods
    Patent number: 9255292
    Abstract: This invention provides a process for making 3?-O-allyl-dGTP-PC-Biodopy-FL-510, 3?-O-allyl-dATP-PC-ROX, 3?-O-allyl-dCTP-PC-Bodipy-650 and 3?-O-allyl-dUTP-PC-R6G, and related methods.
    Type: Grant
    Filed: July 19, 2011
    Date of Patent: February 9, 2016
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Jingyue Ju, Qinglin Meng, Dae H. Kim, Lanrong Bi, Xiaopeng Bai, Nicholas J. Turro
  • Macromonomers for preparation of degradable polymers and model networks
    Patent number: 9200097
    Abstract: The present invention relates to methods for preparing degradable model networks from any monomer functionality with any degradation methodology. It is based on the use of Atom-Transfer Radical Polymerization and CLICK chemistry to form the desired product.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: December 1, 2015
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Jeremiah Johnson, Jeffrey T. Koberstein, Nicholas J. Turro
  • MACROMONOMERS FOR PREPARATION OF DEGRADABLE POLYMERS AND MODEL NETWORKS
    Publication number: 20150299344
    Abstract: The present invention relates to methods for preparing degradable model networks from any monomer functionality with any degradation methodology. It is based on the use of Atom-Transfer Radical Polymerization and CLICK chemistry to form the desired product.
    Type: Application
    Filed: October 21, 2014
    Publication date: October 22, 2015
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Jeremiah Johnson, Jeffrey T. Koberstein, Nicholas J. Turro
  • Heterotrifunctional molecules and methods for the synthesis of dendrimeric materials
    Patent number: 9006345
    Abstract: In one aspect, the present invention is directed to dendrimers comprised of macromolecules and trifunctional branches. In another aspect, the invention relates to methods for generating dendrimeric compositions comprising macromolecules and trifunctional branches. In certain embodiments, the radial density of the dendrimeric composition is controlled by selective incorporation of branches.
    Type: Grant
    Filed: March 26, 2012
    Date of Patent: April 14, 2015
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Jeffrey Lancaster, Jeffrey T. Koberstein, Nicholas J. Turro
  • Photochemical methods and photoactive compounds for modifying surfaces
    Patent number: 8957225
    Abstract: Compounds and methods for controlling the surface properties are described. Compounds of the invention can form radicals upon exposure to irradiation, which can then react with nearby molecules to alter the surface properties of various substrates. The invention can provide surfaces that are resistant to dewetting, surfaces that have immobilized molecules such as carbohydrates and polymers immobilized, and surfaces that have metals deposited on the surface. The invention can be utilized in a wide range of application, such as sensors, microreactors, microarrays, electroless deposition of metals, and the like.
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: February 17, 2015
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Gregory T. Carroll, Jeffrey T. Koberstein, Denong Wang, Nicholas J. Turro
  • Macromonomers for preparation of degradable polymers and model networks
    Patent number: 8895673
    Abstract: The present invention relates to methods for preparing degradable model networks from any monomer functionality with any degradation methodology. It is based on the use of Atom-Transfer Radical Polymerization and CLICK chemistry to form the desired product.
    Type: Grant
    Filed: February 19, 2013
    Date of Patent: November 25, 2014
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Jeremiah Johnson, Jeffrey T. Koberstein, Nicholas J. Turro
  • Photo-generated carbohydrate arrays and the rapid identification of pathogen-specific antigens and antibodies
    Patent number: 8658573
    Abstract: The invention relates to novel photo-generated carbohydrate arrays and methods of their use to detect the presence of one or more agents in a sample. The invention also relates to a high-throughput strategy to facilitate the identification and immunological characterization of pathogen-specific carbohydrates, including those of Bacillus anthracis. The invention can be used to determine the presence of a pathogen and whether a subject has been exposed to a pathogen, such as by screening for pathogen-specific antibodies.
    Type: Grant
    Filed: September 11, 2007
    Date of Patent: February 25, 2014
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Denong Wang, Gregory T. Carroll, Nicholas J. Turro, Jeffrey T. Koberstein
  • Functionalization of organic surfaces
    Patent number: 8507572
    Abstract: The present invention relates to functionalizing a surface of an organic material. For example, surfaces of materials having C—H bonds, such as polymers having C—H bonds, can be functionalized. In certain embodiments, a heterobifunctional molecule having a photoactive anchor, a spacer, and a terminal functional group is applied to the surface of an organic material that contains one or more C—H bonds. The heterobifunctional molecule can be bound to any surface having C—H bonds as the photoactive anchor can react with C—H bonds upon irradiation. The terminal functional group has a “click” functionality which can be utilized to functionalize the surface of the organic material with any desired functionalizing moiety having the orthogonal click functionality.
    Type: Grant
    Filed: June 8, 2010
    Date of Patent: August 13, 2013
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Jeffrey Lancaster, Nicholas J. Turro, Jeffrey T. Koberstein
  • Method of preparing a star polymer macromonomer
    Patent number: 8378041
    Abstract: The present invention relates to methods for preparing degradable model networks from any monomer functionality with any degradation methodology. It is based on the use of Atom-Transfer Radical Polymerization CLICK chemistry and a tetrafunctional initiator having terminal halogen groups to form the desired product.
    Type: Grant
    Filed: January 30, 2009
    Date of Patent: February 19, 2013
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Jeremiah Johnson, Jeffrey T. Koberstein, Nicholas J. Turro
  • HETEROTRIFUNCTIONAL MOLECULES AND METHODS FOR THE SYNTHESIS OF DENDRIMERIC MATERIALS
    Publication number: 20120264881
    Abstract: In one aspect, the present invention is directed to dendrimers comprised of macromolecules and trifunctional branches. In another aspect, the invention relates to methods for generating dendrimeric compositions comprising macromolecules and trifunctional branches. In certain embodiments, the radial density of the dendrimeric composition is controlled by selective incorporation of branches.
    Type: Application
    Filed: March 26, 2012
    Publication date: October 18, 2012
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: JEFFREY LANCASTER, JEFFREY T. KOBERSTEIN, NICHOLAS J. TURRO
  • PHOTOCHEMICAL METHODS AND PHOTOACTIVE COMPOUNDS FOR MODIFYING SURFACES
    Publication number: 20120178650
    Abstract: Compounds and methods for controlling the surface properties are described. Compounds of the invention can form radicals upon exposure to irradiation, which can then react with nearby molecules to alter the surface properties of various substrates. The invention can provide surfaces that are resistant to dewetting, surfaces that have immobilized molecules such as carbohydrates and polymers immobilized, and surfaces that have metals deposited on the surface. The invention can be utilized in a wide range of application, such as sensors, microreactors, microarrays, electroless deposition of metals, and the like.
    Type: Application
    Filed: March 9, 2012
    Publication date: July 12, 2012
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Gregory T. Carroll, Jeffrey T. Koberstein, Denong Wang, Nicholas J. Turro
  • SYNTHESIS OF FOUR-COLOR 3'-O-ALLYL MODIFIED PHOTOCLEAVABLE FLUORESCENT NUCLEOTIDES AND RELATED METHODS
    Publication number: 20120156680
    Abstract: This invention provides a process for making 3?-O-allyl-dGTP-PC-Biodopy-FL-510, 3?-O-allyl-dATP-PC-ROX, 3?-O-allyl-dCTP-PC-Bodipy-650 and 3?-O-allyl-dUTP-PC-R6G, and related methods.
    Type: Application
    Filed: July 19, 2011
    Publication date: June 21, 2012
    Inventors: Jingyue Ju, Qinglin Meng, Dae H. Kim, Lanrong Bi, Xiaopeng Bai, Nicholas J. Turro
  • Photochemical methods and photoactive compounds for modifying surfaces
    Patent number: 8158832
    Abstract: Compounds and methods for controlling the surface properties are described. Compounds of the invention can form radicals upon exposure to irradiation, which can then react with nearby molecules to alter the surface properties of various substrates. The invention can provide surfaces that are resistant to dewetting, surfaces that have immobilized molecules such as carbohydrates and polymers immobilized, and surfaces that have metals deposited on the surface. The invention can be utilized in a wide range of application, such as sensors, microreactors, microarrays, electroless deposition of metals, and the like.
    Type: Grant
    Filed: November 9, 2006
    Date of Patent: April 17, 2012
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Gregory T. Carroll, Denong Wang, Nicholas J. Turro, Jeffrey T. Koberstein
  • Synthesis of four color 3?O-allyl, modified photocleavable fluorescent nucleotides and related methods
    Patent number: 7982029
    Abstract: This invention provides a process for making 3?-O-allyl-dGTP-PC-Biodopy-FL-510, 3?-O-allyl-dATP-PC-ROX, 3?-O-allyl-dCTP-PC-Bodipy-650 and 3?-O-allyl-dUTP-PC-R6G, and related methods.
    Type: Grant
    Filed: October 31, 2006
    Date of Patent: July 19, 2011
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Jingyue Ju, Qinglin Meng, Dae H. Kim, Lanrong Bi, Xiaopeng Bai, Nicholas J. Turro
  • MODIFICATION OF SURFACES WITH NANOPARTICLES
    Publication number: 20110059264
    Abstract: Methods for functionalizing a surface of a substrate with nanoparticles are described. In certain embodiments, the method can include attaching a plurality of photoactive linker to nanoparticles to obtain photoactive nanoparticles, wherein each photoactive linker comprises a binding group that attaches to the nanoparticles and a photoactive group; depositing the photoactive nanoparticles to the surface of the substrate, wherein the surface of the substrate comprises reactive groups that are capable of reacting with the photoactive groups; and irradiating the photoactive nanoparticles with radiation to react the photoactive group with the reactive group and to functionalize the surface of the substrate with nanoparticles.
    Type: Application
    Filed: July 27, 2010
    Publication date: March 10, 2011
    Inventors: Ellane J. Park, Nicholas J. Turro, Jeffrey T. Koberstein