Abstract: A surgical access device and methods for facilitating access through an incision or wound to a surgical site in a patient's body comprising an inferior retention member, a superior retention member, and a pliable membrane therebetween. The pliable membrane includes a base layer, a permeable membrane attached to the base layer, and a fluid channel disposed between the layers. The fluid channel is fluidly coupled to a fluid source. The fluid is delivered to the surgical site via the permeable membrane. The pliable membrane may also provide for fluid removal from the surgical site. The delivered fluid may comprise an antimicrobial fluid chosen to selectively inactivate or prevent the growth of a target microorganism. Methods are provided for determining the risk of surgical site infection, therapeutic regimen, target microorganism likely to require therapeutics, and/or contributing risk factors.