Patents by Inventor Nicholas James Westwood
Nicholas James Westwood has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210130554Abstract: A method of processing a lignocellulosic feedstock includes heating the lignocellulosic feedstock in a solvent mixture comprising an acid and at least 80% by volume of n-butanol to produce a reaction mixture including a butylated lignin. A butylated lignin product wherein at least 85% of the ?-O-4 linkages include n-butyl ether groups can be prepared. Cellulose and butylated hemicellulose products can also be obtained.Type: ApplicationFiled: January 13, 2021Publication date: May 6, 2021Applicant: University Court of the University of St AndrewsInventors: Nicholas James WESTWOOD, Christopher Stuart LANCEFIELD
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Patent number: 10407355Abstract: A method of depolymerizing a lignin includes oxidizing the lignin to provide an oxidized lignin wherein benzylic —OH of ?-O-4 linkages have been converted to carbonyl. The oxidized lignin is depolymerized with a metal selected from the group consisting of zinc, magnesium, aluminum and titanium or mixtures thereof, in the presence of an ammonium salt or carbon dioxide. Also described are methods for manufacturing phenolic products from lignin and a method for the cleavage of a ?-O-4 linkage in a substrate.Type: GrantFiled: August 19, 2015Date of Patent: September 10, 2019Assignee: UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWSInventors: Nicholas James Westwood, Christopher Stuart Lancefield, Fanny Tran
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Publication number: 20190211157Abstract: A method of processing a lignocellulosic feedstock includes heating the lignocellulosic feedstock in a solvent mixture comprising an acid and at least 80% by volume of n-butanol to produce a reaction mixture including a butylated lignin. A butylated lignin product wherein at least 85% of the ?-O-4 linkages include n-butyl ether groups can be prepared. Cellulose and butylated hemicellulose products can also be obtained.Type: ApplicationFiled: August 23, 2017Publication date: July 11, 2019Inventors: Nicholas James WESTWOOD, Christopher Stuart LANCEFIELD
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Publication number: 20170275215Abstract: A method of depolymerising a lignin includes oxidising the lignin to provide an oxidised lignin wherein benzylic —OH of ?-O-4 linkages have been converted to carbonyl. The oxidised lignin is depolymerised with a metal selected from the group consisting of zinc, magnesium, aluminium and titanium or mixtures thereof, in the presence of an ammonium salt or carbon dioxide. Also described are methods for manufacturing phenolic products from lignin and a method for the cleavage of a ?-O-4 linkage in a substrate.Type: ApplicationFiled: August 19, 2015Publication date: September 28, 2017Inventors: Nicholas James Westwood, Christopher Stuart Lancefield, Fanny Tran
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Patent number: 9365508Abstract: The invention provides compounds according to formula (I): (wherein X, Y, Z1 R1, R2, R3, Ar and Ar? are as defined herein), and physiologically acceptable salts, solvates, esters or amides thereof, pharmaceutical compositions comprising these compounds and the compounds for use in medicine, for example for the treatment or prophylaxis of diseases involving cell proliferation, such as cancer, and for the treatment or prophylaxis of other diseases.Type: GrantFiled: June 9, 2010Date of Patent: June 14, 2016Assignees: University Court of the University of St Andrews, University Court of the University of DundeeInventors: Sonia Lain, Nicholas James Westwood, David Philip Lane
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Patent number: 9120765Abstract: The present invention relates to compounds which activate the p53 response, and find use in, for example, hyperproliferative diseases such as cancer treatment and potentially other diseases/conditions involving sirtuin function.Type: GrantFiled: May 3, 2013Date of Patent: September 1, 2015Assignees: University Court of the University of Dundee, University Court of the University of St. AndrewsInventors: Sonia Lain, David Phillip Lane, Michael John Raymond Stark, Anna Rose McCarthy, Jonathan James Hollick, Nicholas James Westwood
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Patent number: 8563557Abstract: The invention provides a compound according to formula (I): wherein: X is O or S; Y is O or S; each Ar and Ar? is independently a mono-, bi- or tricyclic aryl or heteroaryl group optionally substituted with one or more substituents selected from halo, alkyl, aryl, heteroaryl, hydroxyl, nitro, amino, alkoxy, alkylthio, cyano, thio, ester, acyl and amido; each R2 is independently hydrogen, halo, alkyl, aryl, heteroaryl, hydroxyl, nitro, amino, alkoxy, alkylthio, cyano and thio; and R1 is as defined herein, or a physiologically acceptable salt, solvate, ester, amide or other physiologically functional derivative thereof.Type: GrantFiled: October 2, 2009Date of Patent: October 22, 2013Assignees: University Court of the University of Dundee, University Court of the University of St AndrewsInventors: Nicholas James Westwood, Sonia Lain, Federico Medda
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Patent number: 8501991Abstract: The present invention relates to compounds which activate the p53 response, and find use in, for example, hyperproliferative diseases such as cancer treatment and potentially other diseases/conditions (involving sirtuin function).Type: GrantFiled: September 4, 2007Date of Patent: August 6, 2013Assignees: University Court of the University of Dundee, University Court of the University of St. AndrewsInventors: Sonia Lain, David Phillip Lane, Michael John Raymond Stark, Anna Rose McCarthy, Jonathan James Hollick, Nicholas James Westwood
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Publication number: 20120149778Abstract: The invention provides compounds according to formula (I): (wherein X, Y, Z1 R1, R2, R3, Ar and Ar? are as defined herein), and physiologically acceptable salts, solvates, esters or amides thereof, pharmaceutical compositions comprising these compounds and the compounds for use in medicine, for example for the treatment or prophylaxis of diseases involving cell proliferation, such as cancer, and for the treatment or prophylaxis of other diseases.Type: ApplicationFiled: June 9, 2010Publication date: June 14, 2012Inventors: Sonia Lain, Nicholas James Westwood, David Philip Lane
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Publication number: 20110245282Abstract: The invention provides a compound according to formula (I): wherein: X is O or S; Y is O or S; each Ar and Ar? is independently a mono-, bi- or tricyclic aryl or heteroaryl group optionally substituted with one or more substituents selected from halo, alkyl, aryl, heteroaryl, hydroxyl, nitro, amino, alkoxy, alkylthio, cyano, thio, ester, acyl and amido; each R2 is independently hydrogen, halo, alkyl, aryl, heteroaryl, hydroxyl, nitro, amino, alkoxy, alkylthio, cyano and thio; and R1 is as defined herein, or a physiologically acceptable salt, solvate, ester, amide or other physiologically functional derivative thereof.Type: ApplicationFiled: October 2, 2009Publication date: October 6, 2011Inventors: Nicholas James Westwood, Sonia Lain, Federico Medda
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Publication number: 20110021529Abstract: The present invention relates to compounds which activate the p53 response, and find use in, for example, hyperproliferative diseases such as cancer treatment and potentially other diseases/conditions (involving sirtuin function).Type: ApplicationFiled: September 4, 2007Publication date: January 27, 2011Applicants: UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE, UNIVERSITY COURT OF THE UNIVERSITY OF ST. ANDREWSInventors: Sonia Lain, David Phillip Lane, Michael John Raymond Stark, Anna Rose McCarthy, Jonathan James Hollick, Nicholas James Westwood
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Patent number: 7868184Abstract: There is provided a method to convert O-functionalized indazolinone-derivatives to the corresponding N2-functionalized indazolinone derivatives, by use of microwave energy or a transition metal catalyst. A preferred catalyst is palladium tetrakis. The method described allows the creation of a library of chemical compounds which can be screened for biological activity.Type: GrantFiled: June 8, 2005Date of Patent: January 11, 2011Assignee: The University of the University of St. AndrewsInventors: Nicholas James Westwood, Nicolas Stanislas Jean Isambert
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Patent number: 7442804Abstract: The present invention relates to a process for the preparation of furopyrroles of general formula (I), comprising (a) heating a compound of the formula (II) under microwave irradiation optionally in the presence of an inert solvent, wherein A1 and A2 are C1-C18alkyl, C2-C18alkenyl, C2-C18alkynyl, C5-C8cycloalkyl, C5-C8cycloalkenyl, aryl or heteroaryl, A3 is hydrogen, C1-C18alkyl, cyanomethyl, Ar3, —CR30R31—(CH2)m—Ar3 or Y—R32, wherein R30 and R31 independently of each other stand for hydrogen or C1-C4alkyl, or phenyl which can be substitute up to three times with C1-C4alkyl, Ar3 stands for aryl, C5-C8 cloalkyl, C5-C8cycloalkenyl or heteroaryl, which can be substituted one to three times with C1-C8alkyl, C1-C8alkoxy, halogen or phenyl, which can be substituted with C1-C8alkyl or C1-C8alkoxy one to three times, and m stands for 0, 1, 2, 3 or 4, R is C1-C18alkyl, in particular C1-C4alkyl, aryl, in particular phenyl, or aralkyl, in particular benzyl, which can be substituted one to three times with C1-C8alkyl, C1Type: GrantFiled: June 28, 2004Date of Patent: October 28, 2008Assignee: Ciba Specialty Chemicals CorporationInventors: Richard Lewis Riggs, Nicholas James Westwood, David Macdonald Smith, Colin Morton