Patents by Inventor Nicholas John Newcombe

Nicholas John Newcombe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterocyclic compounds useful as pharmaceutical agents
    Patent number: 6313127
    Abstract: Compounds of formula (I) in which all variables are defined in the description and their salts inhibit the enzyme oxido squalene cyclase and are useful in treating hypercholesterolemia and also as anti-fungal agents. Processes for their preparation are also described together with their use in medicine.
    Type: Grant
    Filed: July 31, 1998
    Date of Patent: November 6, 2001
    Assignee: Zeneca Limited
    Inventors: David Waterson, Elaine Sophie Elizabeth Stokes, George Robert Brown, John Graham Cumming, Nicholas John Newcombe, Robin Wood, William John Watkins
  • Substituted pyrimidine derivatives and their pharmaceutical use
    Patent number: 6093718
    Abstract: This invention concerns heterocyclic derivatives which are useful in inhibiting oxido-squalene cyclase, processes for their preparation and pharmaceutical compositions containing them. The present invention is also concerned with heterocyclic derivatives capable of inhibiting cholesterol biosynthesis and hence in lowering cholesterol levels in blood plasma. The present invention also relates to methods of using such heterocyclic derivatives in diseases and medical conditions such as hypercholesterolemia and atherosclerosis.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: July 25, 2000
    Assignee: Zeneca Limited
    Inventors: David Waterson, Elaine Sophie Elizabeth Stokes, George Robert Brown, Nicholas John Newcombe