Patents by Inventor Nicholas John Silvester Huby

Nicholas John Silvester Huby has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thiazole derivatives as inhibitors of Bruton's tyrosine kinase
    Patent number: 9359345
    Abstract: This application discloses compounds according to generic Formula I: wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.
    Type: Grant
    Filed: December 9, 2013
    Date of Patent: June 7, 2016
    Assignee: HOFFMANN-LA ROCHE INC.
    Inventors: Nicholas John Silvester Huby, Francisco Javier Lopez-Tapia, Sung-Sau So
  • THIAZOLE DERIVATIVES AS INHIBITORS OF BRUTON'S TYROSINE KINASE
    Publication number: 20150353534
    Abstract: This application discloses compounds according to generic Formula I: wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.
    Type: Application
    Filed: December 9, 2013
    Publication date: December 10, 2015
    Inventors: Nicholas John Silvester Huby, Francisco Javier Lopez-Tapia, Sung-Sau So