Patents by Inventor Nicholas Joseph Hrib

Nicholas Joseph Hrib has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6284775
    Abstract: There are disclosed compounds of the formula, where n is 0, 1 or 2; A is where X in each occurrence is independently hydrogen, halogen, loweralkyl, hydroxy, nitro, loweralkoxy, amino, cyano, trifluoromethyl or methylthio; Y in each occurrence is independently hydrogen, halogen, loweralkyl, hydroxy, nitro, loweralkoxy, amino, cyano, trifluoromethyl or methylthio; K is N or CH; m is 1 or 2; k is 1 or 2; R1 and R2 are independently hydrogen, loweralkyl, or aryl except that when R1 is or aryl, R2 is hydrogen, or alternatively R1+R2 taken together with the carbon atom to which they are attached form a cyclopentane, cyclohexane, cycloheptane, pyran, thiopyran, indan or piperidine ring; R3 and R4 are independently hydrogen or loweralkyl, or alternatively R3+R4 taken together with the carbon atom to which they are attached form a cyclopentane, cyclohexane, cycloheptane, pyran, thiopyran, pyrrolidine or piperidine ring, the term aryl sig
    Type: Grant
    Filed: June 17, 1998
    Date of Patent: September 4, 2001
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Nicholas Joseph Hrib, John Gerard Jurcak
  • Patent number: 5869480
    Abstract: There are disclosed various substituted 4-amino-3-pyridinol compounds of the formula below, ##STR1## where R.sub.1, R.sub.2 and R.sub.3 are as defined in the specification, which are useful for alleviating various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease.
    Type: Grant
    Filed: June 2, 1998
    Date of Patent: February 9, 1999
    Assignee: Hoechst Marion Roussel Inc.
    Inventors: Gregory Michael Shutske, Kevin James Kapples, John Dick Tomer, Nicholas Joseph Hrib, John Gerard Jurcak
  • Patent number: 5866565
    Abstract: There are disclosed various substituted 4-amino-3-pyridinol compounds of the formula below, ##STR1## where R.sub.1, R.sub.2 and R.sub.3 are as defined in the specification, which are useful for alleviating various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease.
    Type: Grant
    Filed: June 2, 1998
    Date of Patent: February 2, 1999
    Assignee: Hoechst Marion Roussel Inc.
    Inventors: Gregory Michael Shutske, Kevin James Kapples, John Dick Tomer, Nicholas Joseph Hrib, John Gerard Jurcak
  • Patent number: 5821239
    Abstract: There are disclosed various substituted 4-amino-3-pyridinol compounds of the formula below, ##STR1## where R.sub.1, R.sub.2 and R.sub.3 are as defined in the specification, which are useful for alleviating various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease.
    Type: Grant
    Filed: February 16, 1996
    Date of Patent: October 13, 1998
    Assignee: Frommer Lawrence & Huag LLP
    Inventors: Gregory Micahel Shutske, Kevin James Kapples, John Dick Tomer, Nicholas Joseph Hrib, John Gerard Jurcak
  • Patent number: 5801186
    Abstract: A compound selected from the following formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, X, m and n are as defined in the specification having antipsychotic activity.
    Type: Grant
    Filed: October 9, 1996
    Date of Patent: September 1, 1998
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Nicholas Joseph Hrib, John Gerard Jurcak
  • Patent number: 5801176
    Abstract: This invention relates to compounds of the formula ##STR1## wherein X is halogen, hydroxy, (C.sub.1 -C.sub.6)alkoxy, amino or trifluoromethyl; andY is --CN or --NR.sup.1 R.sup.2 ;wherel is an integer of 0, 1 or 2;m is an integer of 0, 1 or 2;n is an integer of 2, 3 or 4, except when Y is CN, in which case n can also be 1;R.sup.1 is hydrogen, (C.sub.1 -C.sub.6)alkyl or (C.sub.1 -C.sub.6)alkylcarbonyl;R.sup.2 is hydrogen, (C.sub.1 -C.sub.10)alkylcarbonyl, (C.sub.3 -C.sub.12)cycloalkylcarbonyl, hydroxy-(C.sub.1 -C.sub.6)alkylcarbonyl, phenylcarbonyl, thienylcarbonyl or benzothienylcarbonyl;orR.sub.1 and R.sup.2 together with nitrogen atom to which they are attached form the ring ##STR2## where A is C.dbd.O or CH.sub.2 ;andB is C.dbd.O, CHOH, CH.sub.2 or CH.sub.2 CH.sub.2 ; andZ is halogen, hydroxy, (C.sub.1 -C.sub.6)alkoxy, amino or trifluoromethyl p is 0 or 1; and pharmaceutically acceptable acid addition salts thereof, pharmaceutical compositions thereof and their use for the treatment of psychoses.
    Type: Grant
    Filed: June 6, 1997
    Date of Patent: September 1, 1998
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Nicholas Joseph Hrib, John Gerard Jurcak, Abdul E. Mutlib