Patent number: 6284775
Abstract: There are disclosed compounds of the formula,
where n is 0, 1 or 2; A is
where X in each occurrence is independently hydrogen, halogen, loweralkyl, hydroxy, nitro, loweralkoxy, amino, cyano, trifluoromethyl or methylthio; Y in each occurrence is independently hydrogen, halogen, loweralkyl, hydroxy, nitro, loweralkoxy, amino, cyano, trifluoromethyl or methylthio; K is N or CH; m is 1 or 2; k is 1 or 2; R1 and R2 are independently hydrogen, loweralkyl,
or aryl except that when R1 is
or aryl, R2 is hydrogen, or alternatively R1+R2 taken together with the carbon atom to which they are attached form a cyclopentane, cyclohexane, cycloheptane, pyran, thiopyran, indan or piperidine ring; R3 and R4 are independently hydrogen or loweralkyl, or alternatively R3+R4 taken together with the carbon atom to which they are attached form a cyclopentane, cyclohexane, cycloheptane, pyran, thiopyran, pyrrolidine or piperidine ring, the term aryl sig
Type:
Grant
Filed:
June 17, 1998
Date of Patent:
September 4, 2001
Assignee:
Aventis Pharmaceuticals Inc.
Inventors:
Nicholas Joseph Hrib, John Gerard Jurcak