Abstract: The present invention relates to novel peptides that are derivatives of glucose-dependent insulinotropic polypeptide (GIP) analogues having improved physical stability in solution and a protracted profile of action. More particular the invention relates to such peptides that are agonists at the GIP receptor and to their use in weight management or for treatment of diseases such as obesity, diabetes or non-alcoholic steatohepatitis (NASH).

Abstract: A method is provided that includes receiving, at a media device and from a client device, a request for a temporary identifier for a group chat session, and provisioning, by the media device, the temporary identifier based on a device identifier of the media device. The media device provides the temporary identifier to the client device. The media device receives from a server an invitation to join the group chat session, where the invitation is directed to the temporary identifier, and the media device joins the group chat session.

Abstract: A speckle-suppressing lighting system includes an optical waveguide, a first solid-state light source, a second solid-state light source, and a diffuser. The optical waveguide has a proximal end and a distal end. At least part of the diffuser is between the proximal end and the distal end. The first solid-state light source is optically coupled to the optical waveguide near the proximal end, and emits a first light beam that propagates toward the distal end and has a first center wavelength. The second solid-state light source is optically coupled to the optical waveguide near the proximal end, and emits a second light beam that propagates toward the distal end and has a second center wavelength differing from the first center wavelength. The diffuser diffuses the first light beam and the second light beam.

Abstract: A method can comprise forming a component comprising a first mating surface; coupling the component to an airfoil having a second mating surface and a Field Assisted Sintering Technology (“FAST”) system; heating, via the FAST system, the airfoil and the component; and applying, via the FAST system, a mechanical pressure between the first mating surface and the second mating surface to join the airfoil to the component and form a blade, the component at least partially defining a leading edge of the blade in response to joining the airfoil to the component

Abstract: Membrane electrode assemblies for fuel cells and components thereof are provided. In one example, a membrane electrode assembly includes a generally planar gas-permeable body having opposed first and second faces defining in-plane directions and a through-plane direction, a side face extending about an outer perimeter of the body and adjoining each of the first and second faces, and an active region bounded in the through-plane direction by the first and second faces and in the in-plane directions by an active region perimeter defined generally within the outer perimeter. The active region includes a distribution of a composite compound additive dispersed across at least one of the in-plane and through-plane directions. The composite compound additive includes a metal oxide-containing sub-compound and a tungsten-containing sub-compound.

Abstract: A push notification distribution system centralizes the management and delivery of push notifications to applications executing on electronic devices. Registration requests to register applications for push notifications may be aggregated and sent as an aggregated registration request. The delivery priority of push notifications may be managed according to specified preferences. Upon receiving a push notification intended for an electronic device, a delivery priority of the push notification may be changed if an application identifier associated with the push notification is found on a list of application identifiers with designed delivery priorities.

Abstract: A gas infusion tank for a beverage machine includes a tank body defining a holding space for accommodating beverages. A mixing element includes a mixing chamber, an ascending pipe, and a descending pipe. A top of the ascending pipe is fluidly connected to the mixing chamber and a bottom of the ascending pipe has a liquid inlet. The liquid inlet is fluidly connected to the holding space. A top of the descending pipe is fluidly connected to the mixing chamber and a bottom of the descending pipe includes a liquid outlet in fluid communication with the nozzle. A gas intake hole connects the holding space with the mixing chamber.

Abstract: Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders.

Abstract: Anion exchange polymers comprise a plurality of repeating units of formula (I). The polymer may be synthesized from a super acid catalyzed polyhydroxyalkylation reaction of monomers Ar1?, Ar2?, and X1? to form a neutral precursor polymer followed by a Menshutkin reaction to convert the neutral precursor polymer to the anion exchange polymer. Anion exchange membranes and membrane electrode assemblies incorporating the anion exchange polymers are also described.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: Described herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, such as cancer, metabolic and blood disorders. Compounds of Formula (I) have the following structure of Formula (I).

Abstract: Systems and methods are provided for dynamically modeling and depicting overall emissions of the aviation industry and changes thereto when taking into account, for example, traffic growth and introduction of sustainability strategies, such as new and/or improved technologies, an increase in operational efficiency, and carbon offsets. Using the dynamic tool described herein, users can define scenarios on how to reduce emissions through the introduction of different sustainability strategies, both statically and over time, analyze the impact of those strategies on emissions, and understand the dependencies between select strategies.

Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

Abstract: A system and method for multiplying matrices are provided. The system includes a processor coupled to a memory and a matrix multiply accelerator (MMA) coupled to the processor. The MMA is configured to multiply, based on a bitmap, a compressed first matrix and a second matrix to generate an output matrix including, for each element i,j of the output matrix, a calculation of a dot product of an ith row of the compressed first matrix and a jth column of the second matrix based on the bitmap. Or, the MMA is configured to multiply, based on the bitmap, the second matrix and the compressed first matrix and to generate the output matrix including, for each element i,j of the output matrix, a calculation of a dot product of an ith row of the second matrix and a jth column of the compressed first matrix based on the bitmap.

Abstract: A surface cleaning apparatus including a body defining an agitation chamber, an agitator partially disposed within the agitation chamber and configured to rotate about a pivot axis, and a debrider at least partially disposed within the agitation chamber. The agitator includes an elongated body having a first and a second end, a sidewall extending radially outward from the elongated body extending between the first and the second ends, and a plurality of bristles extending radially outward from the elongated body. The plurality of bristles are arranged in at least one row adjacent to the sidewall. The debrider includes a plurality of teeth configured to contact a portion of the sidewall as the agitator rotates about the pivot axis.

Abstract: A method for recognizing a reference point associated with a fiducial marker including the steps of: obtaining or receiving image data of the fiducial marker; determining the degree of which the image data of the fiducial marker is aligned with one or more reference images; of which if the degree of alignment is determined to be less than an acceptable threshold predicting a set of coordinates of the reference point associated with the fiducial marker; incorporating the set of coordinates with the image data to form a modified image data; and determining the degree of which the modified image data of the fiducial marker is aligned with one or more reference images.

Abstract: The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.

Abstract: A push notification distribution system centralizes the management and delivery of push notifications to applications executing on electronic devices. Registration requests to register applications for push notifications may be aggregated and sent as an aggregated registration request. The delivery priority of push notifications may be managed according to specified preferences. Upon receiving a push notification intended for an electronic device, a delivery priority of the push notification may be changed if an application identifier associated with the push notification is found on a list of application identifiers with designed delivery priorities.

Abstract: Provided are systems and methods for drying a cereal grass, such as alfalfa, barley, clover, rye grass, Timothy grass, and the stalks, stems, grains and leaves of a cereal grass, such as oats, wheat, buckwheat, maize, millet, rice and sorghum. The systems include a first pressing roll and a second pressing roll that form a nip through which the cereal grass or forage crop can be pressed, pressing the liquid out of the cereal grass or forage crop to form a first product stream comprising a dewatered cereal grass or forage crop and a second product stream comprising liquid pressed out of the cereal grass or forage crop; at least one suction device for collecting the second product stream; an atomizer for converting the second product stream into droplets that can be applied to the surface of the first product stream; a drying chamber; and a circulation system for moving a drying medium through the drying chamber.

Abstract: Provided are door systems having a plurality of door panels and a frame, the door panels being movable horizontally between an extended position closing an opening in a building structure, and a folded retracted position opening the opening in the building structure. When in the extended position, the door panels interlock with each other forming a barrier to wind, dirt, dust and insects. The frame is movably attached to the building structure and when the door panels are in the extended position, the frame moves and engages the door panels with a sealing member to provide an airtight seal of the opening in the building structure.