Abstract: Described herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, such as cancer, metabolic and blood disorders. Compounds of Formula (I) have the following structure of Formula (I).

Abstract: A computer-implemented process is programmed to process a source input, determine text enhancements, and present the text enhancements to apply to the sentences dictated from the source input. A text processor may use machine-learning models to process an audio input to generate sentences in a presentable format. An audio input can be processed by an automatic speech recognition model to generate electronic text. The electronic text may be used to generate sentence structures using a normalization model. A comprehension model may be used to identify instructions associated with the sentence structures and generate sentences based on the instructions and the sentence structures. An enhancement model may be used to identify enhancements to apply to the sentences. The enhancements may be presented alongside sentences generated by the comprehension model to provide the user an option to select either the enhancements or the sentences.

Abstract: Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders.

Abstract: A sheath can be used to protect a catheter hub from contamination. The sheath can surround the catheter hub and seal the interface between the catheter hub and a needleless connector. The sheath can be installed onto the catheter hub either before or after the needleless connector has been connected to the catheter hub.

Abstract: Aspects of the present disclosure are presented for a combustion engine design with an optimized amount of materials used to generate the necessary components of the engine. The engine may be generated as a single piece, having no joints, fasteners, or any other areas that could present a risk for damage. The designs are described may also reduce weight of the engine, due to eliminating the need for fasteners and other extraneous hardware. In general, the weight of the engine may be optimized to also preclude the inclusion of extraneous material around needed structures. Also, the engine may be designed to be highly energy efficient, with optimal flows for fuel and other fluid with minimal head loss while maintaining higher pressures.

Abstract: A sheath can be used to protect a catheter hub from contamination. The sheath can surround the catheter hub and seal the interface between the catheter hub and a needleless connector. The sheath can be installed onto the catheter hub either before or after the needleless connector has been connected to the catheter hub.