Abstract: Provided are methods of detecting a biomolecule of interest in a sample. In certain embodiments, the methods comprise contacting the sample with a biolayer interferometry (BLI) sensor, the BLI sensor comprising a capture antigen specific for the biomolecule affixed to the BLI sensor, wherein a wavelength shift detected by the BLI sensor indicates the presence of the biomolecule of interest in the sample. The methods may further comprise contacting the BLI sensor with a detecting reagent (e.g., an antibody or the like) specific for the biomolecule of interest, where the detecting reagent is conjugated to a colloidal gold particle or other signal enhancing molecule. In certain embodiments, the biomolecule of interest is an antibody specific for a viral antigen, e.g., a SARS-CoV-2 antigen-specific antibody, or the like. Also provided are BLI sensors and kits that find use, e.g., in practicing the methods of the present disclosure.

Abstract: Provided are pyrroloquinolin compounds of formula (1) or (II). In certain aspects, the pyrroloquinolin compounds are therapeutic, e.g., for treating a cell proliferative disorder. Also provided are conjugates that include the pyrroloquinolin compounds of the present disclosure. Compositions, e.g., pharmaceutical compositions, that include the pyrroloquinolin compounds and conjugates of the present disclosure are also provided. Further provided are therapeutic methods involving the administration of the pyrroloquinolin compounds, conjugates or compositions of the present disclosure. Kits that include the pyrroloquinolin compounds, conjugates or compositions are also provided.

Abstract: Provided are pyrroloquinolin compounds of formula (1) or (II). In certain aspects, the pyrroloquinolin compounds are therapeutic, e.g., for treating a cell proliferative disorder. Also provided are conjugates that include the pyrroloquinolin compounds of the present disclosure. Compositions, e.g., pharmaceutical compositions, that include the pyrroloquinolin compounds and conjugates of the present disclosure are also provided. Further provided are therapeutic methods involving the administration of the pyrroloquinolin compounds, conjugates or compositions of the present disclosure. Kits that include the pyrroloquinolin compounds, conjugates or compositions are also provided.