Patents by Inventor Nicholas Luksha

Nicholas Luksha has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LYOPHILIZED FORMULATIONS FOR SMALL MODULAR IMMUNOPHARMACEUTICALS
    Publication number: 20120114646
    Abstract: The present invention provides, among other things, stable formulations for small modular immunopharmaceutical (SMIP™) proteins. In some embodiments, the present invention provides a formulation containing a lyophilized mixture of a small modular immunopharmaceutical protein, wherein less than 7% of the lyophilized small modular immunopharmaceutical protein exists in aggregated form. Formulations according to the invention may contain buffering agents, stabilizers, bulking agents, surfactants and/or other excipients. The present invention also provides formulations for lyophilization, reconstitution and methods of use thereof.
    Type: Application
    Filed: June 18, 2010
    Publication date: May 10, 2012
    Applicant: WYETH LLC
    Inventors: Serguei Tchessalov, Angela Kantor, Li Li, Nicholas Luksha, Nicholas Warne
  • IMMUNOGLOBULIN FUSION PROTEIN FORMULATIONS
    Publication number: 20110033464
    Abstract: The present invention provides compositions of Ig fusion proteins, especially compositions including an Ig fusion protein, a bulking agent, a disaccharide, a surfactant, and a buffer. In one aspect, these compositions are stable under long-term storage or at least one freeze/thaw cycle. The invention also provides methods of preparation of the Ig fusion protein compositions. In one aspect, compositions of the invention are lyophilized. In a further aspect, the compositions are lyophilized by a process that includes an annealing step.
    Type: Application
    Filed: October 22, 2010
    Publication date: February 10, 2011
    Inventors: Anthony BARRY, Thomas Crowley, Daniel Dixon, Jennifer Juneau, Ajay Kumar, Li Li, Nicholas Luksha, Michael Shamashkin, Erin Soley, Nicholas Warne, Chandra Webb
  • Methods for reducing protein aggregation
    Publication number: 20080064856
    Abstract: Methods of reducing aggregation of a protein or proteins in a formulation, and protein formulations having reduced aggregation properties are provided. The methods and formulations described herein maintain the biological activity of a protein and increase the shelf life of protein formulations.
    Type: Application
    Filed: March 19, 2007
    Publication date: March 13, 2008
    Applicant: Wyeth
    Inventors: Nicholas Warne, Angela Kantor, Thomas Crowley, Erin Soley, Li Li, Nicholas Luksha, Edie Neidhardt
  • IMMUNOGLOBULIN FUSION PROTEIN FORMULATIONS
    Publication number: 20070237758
    Abstract: The present invention provides compositions of Ig fusion proteins, especially compositions including an Ig fusion protein, a bulking agent, a disaccharide, a surfactant, and a buffer. In one aspect, these compositions are stable under long-term storage or at least one freeze/thaw cycle. The invention also provides methods of preparation of the Ig fusion protein compositions. In one aspect, compositions of the invention are lyophilized. In a further aspect, the compositions are lyophilized by a process that includes an annealing step.
    Type: Application
    Filed: November 21, 2006
    Publication date: October 11, 2007
    Inventors: Anthony Barry, Thomas Crowley, Daniel Dixon, Jennifer Juneau, Ajay Kumar, Li Li, Nicholas Luksha, Michael Shamashkin, Erin Soley, Nicholas Warne, Chandra Webb