Abstract: Devices and methods for performing in vitro fertilization (“IVF”) and maximizing successful fertilization rates by optimizing the fluid flow conditions under which zygotes are transferred from growth medium to the uterine wall. The apparatus has a control unit with an external port and an internal pump for creating positive and negative fluid pressure at the port. A flexible extension hose connects the port to an inter-uterine catheter assembly. The catheter assembly has an inner catheter and an outer sheath surrounding the inner catheter. The control unit includes a programmable microprocessor that accepts input commands and controls operation of the pump. Optionally, the control unit has remote control means for activating, de-activating, and reversing the flow of the pump. The control unit can be programmed to repeatedly provide the same aspiration and expulsion flow conditions through the catheter assembly.

Abstract: A rugged, all-electronic fluid dispensing system for use with pipettes or in other contexts indirectly measures fluid flow by using a non-linear system model to correlate vacuum existing at the top of a column of suspended fluid. Non-contact operation is provided to eliminate the need for contact-type closed-loop fluid flow sensing and associated potential cross-contamination risks. In one particular exemplary non-limiting illustrative implementation, an electronic controller within a gun-shaped, cordless self-contained pipetter housing dynamically calculates valve opening time based on a non-linear equation. Calibration is used to derive equation constants, and column vacuum pressure before the valve is opened is used as the independent variable to derive a valve opening time that will result in accurate dispensing of a desired programmed fluid quantity.

Abstract: A rugged, all-electronic fluid dispensing system for use with pipettes or in other contexts indirectly measures fluid flow by using a non-linear system model to correlate vacuum existing at the top of a column of suspended fluid. Non-contact operation is provided to eliminate the need for contact-type closed-loop fluid flow sensing and associated potential cross-contamination risks. In one particular exemplary non-limiting illustrative implementation, an electronic controller within a gun-shaped, cordless self-contained pipetter housing dynamically calculates valve opening time based on a non-linear equation. Calibration is used to derive equation constants, and column vacuum pressure before the valve is opened is used as the independent variable to derive a valve opening time that will result in accurate dispensing of a desired programmed fluid quantity.

Abstract: A pipette dispenser unit having a hand-held pipette dispenser having a pipette connector and a handle, a source of positive and negative air pressure in fluid connection with said pipette connector, and a foot-operated controller for regulating the flow of air between said air pressure source and said pipette connector. A method of metering fluid through a pipette by connecting the pipette to the pipette dispenser, holding the dispenser with one hand, and controlling fluid flow through the pipette by operating the controller with at least one foot.

Abstract: A pipette dispenser unit having a hand-held pipette dispenser having a pipette connector and a handle, a source of positive and negative air pressure in fluid connection with said pipette connector, and a foot-operated controller for regulating the flow of air between said air pressure source and said pipette connector. A method of metering fluid through a pipette by connecting the pipette to the pipette dispenser, holding the dispenser with one hand, and controlling fluid flow through the pipette by operating the controller with at least one foot.