Patents by Inventor Nicholas M. Valiante

Nicholas M. Valiante has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF TRYPTANTHRIN COMPOUNDS FOR IMMUNE POTENTIATION
    Publication number: 20120244182
    Abstract: The invention provides immunostimulatory compositions and methods of administration thereof. Also provided are methods of administering a tryptanthrin compound in an effective amount to enhance the immune response of a subject to an antigen. Also provided are methods of administering an effective amount of a tryptanthrin to stimulate the immune response in a subject for the treatment of cancer. Further provided are methods of administering a tryptanthrin compounds as an immunotherapeutic in the treatment of infectious diseases.
    Type: Application
    Filed: June 4, 2012
    Publication date: September 27, 2012
    Applicant: NOVARTIS VACCINES AND DIAGNOSTICS, INC.
    Inventor: Nicholas M. VALIANTE
  • Use of tryptanthrin compounds for immune potentiation
    Patent number: 8193185
    Abstract: The invention provides immunostimulatory compositions and methods of administration thereof. Also provided are methods of administering a tryptanthrin compound in an effective amount to enhance the immune response of a subject to an antigen. Also provided are methods of administering an effective amount of a tryptanthrin to stimulate the immune response in a subject for the treatment of cancer. Further provided are methods of administering a tryptanthrin compounds as an immunotherapeutic in the treatment of infectious diseases.
    Type: Grant
    Filed: January 21, 2004
    Date of Patent: June 5, 2012
    Assignee: Novartis Vaccines and Diagnostics, Inc.
    Inventor: Nicholas M. Valiante
  • Use of small molecule compounds for immunopotentiation
    Patent number: 7893096
    Abstract: The invention provides immunostimulatory compositions comprising a small molecule immuno-poteniator (SMIP) compound and methods of administration thereof. Also provided are methods of administering a SMIP compound in an effective amount to enhance the immune response of a subject to an antigen. Further provided are novel compositions and methods of administering SMIP compounds alone or in combination with another agent for the treatment of cancer, infectious diseases and/or allergies/asthma.
    Type: Grant
    Filed: March 29, 2004
    Date of Patent: February 22, 2011
    Assignee: Novartis Vaccines and Diagnostics, Inc.
    Inventor: Nicholas M. Valiante, Jr.
  • METHODS FOR THE PREPARATION OF IMIDAZOLE-CONTAINING COMPOUNDS
    Publication number: 20100010217
    Abstract: The present invention generally relates to methods for the preparation of compounds that contain imidazole moieties. In some embodiments, the methods include the reaction of a diamine with a dichloroimmonium compound to produce the imidazole moiety. In some embodiments, the methods are employed to prepare compounds having the Formulas II, II or III below: I II III wherein the constituent variables are as described herein.
    Type: Application
    Filed: March 23, 2007
    Publication date: January 14, 2010
    Inventors: Nicholas M. Valiante, James Sutton, Jiong Lan
  • IMIDAZOQUINOXALINE COMPOUNDS AS IMMUNOMODULATORS
    Publication number: 20090311288
    Abstract: The invention proyides novel compositions comprising imidazoquinoxaline compounds of formula (I) and analogs thereof. Also provided are methods of administering the compositions in an effective amount to enhance the immune response of a subject. Further provided are novel compositions and methods of administering the compositions in combination with (an) other agent (s).
    Type: Application
    Filed: March 23, 2007
    Publication date: December 17, 2009
    Applicant: Novartis AG
    Inventors: James Sutton, Feng Xu, Nicholas M. Valiante, JR., Jiong Lan
  • Use of tryptanthrin compounds for immune potentiation
    Publication number: 20040241192
    Abstract: The invention provides immunostimulatory compositions and methods of administration thereof. Also provided are methods of administering a tryptanthrin compound in an effective amount to enhance the immune response of a subject to an antigen. Also provided are methods of administering an effective amount of a tryptanthrin to stimulate the immune response in a subject for the treatment of cancer. Further provided are methods of administering a tryptanthrin compounds as an immunotherapeutic in the treatment of infectious diseases.
    Type: Application
    Filed: January 21, 2004
    Publication date: December 2, 2004
    Applicant: Chiron Corporation
    Inventor: Nicholas M. Valiante
  • Human cytotoxic lymphocyte signal transduction surface protein (P38) and monoclonal antibodies thereto
    Patent number: 5688690
    Abstract: The present invention provides a novel monoclonal antibody, mAb C1.7, and its antigenic receptor, p38, which is an NK cell and CD8.sup.+ T cell activating structure. Methods of using these compositions to identify and monitor the course of a disease, as well as for therapeutic purposes, are disclosed.
    Type: Grant
    Filed: September 16, 1994
    Date of Patent: November 18, 1997
    Assignee: The Wistar Institute of Anatomy and Biology
    Inventors: Nicholas M. Valiante, Giorgio Trinchieri