Patents by Inventor Nicholas M. Vernon
Nicholas M. Vernon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7049435Abstract: The present invention relates to novel extractive methods for purifying sucralose. The present invention also relates to compositions comprising the sucralose preparations made by the methods of the present invention.Type: GrantFiled: March 8, 2002Date of Patent: May 23, 2006Assignee: Tate & Lyle Public Limited CompanyInventors: Steven J. Catani, Nicholas M. Vernon, David Saul Neiditch, James Edwin Wiley, Jr., Edward Micinski
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Patent number: 6998480Abstract: This invention relates to processes for purifying sucralose by the use of an initial non-crystallization purification procedure followed by three or more sequential crystallization steps and recycle of the mother liquor remaining from each crystallization step to the feed of another crystallization or purification step. This invention also relates to sucralose compositions as well as compositions comprising the sucralose compositions of the present invention. These compositions may be highly pure and have a superior taste profile.Type: GrantFiled: March 8, 2002Date of Patent: February 14, 2006Assignee: Tate & Lyle Public Limited CompanyInventors: Steven J. Catani, James E. Wiley, Nicholas M. Vernon, Carolyn M. Merkel, Edward Micinski
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Patent number: 6943248Abstract: A crystalline form of sucralose, and a method of making it. The method involves continuously crystallizing sucralose from an aqueous solution by a process providing continuous removal and recirculation of the vessel contents, and providing a long residence time for sucralose in the system. The crystals thus formed are of a relatively low length/diameter ratio, have an unsymmetrical shape, and exhibit good stability. The larger crystals in particular are tapered as compared to the rod-like larger crystals in prior art product.Type: GrantFiled: April 30, 2003Date of Patent: September 13, 2005Assignee: Tate & Lyle Public Limited CompanyInventors: Steven J. Catani, Carolyn M. Merkel, Nicholas M. Vernon
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Patent number: 6890581Abstract: The present invention relates to novel methods for stabilizing aqueous deacylation, via use of buffers in the production of sucralose. The present invention provides a process for producing sucralose from an acyl-sucralose compound whereby the acyl-sucralose compound is deacylated in the presence of a buffering agent, which stabilizes the pH of the feed mixture and decreases the accumulation of undesired anhydro compounds. Further, the present invention provides a process whereby the acyl-sucralose compound is deacylated directly either prior to or after removal of the tertiary amide reaction vehicle from the neutralized chlorination feed mixture. An aqueous solution of sucralose including salts and other compounds is produced, from which sucralose is recovered by extraction and purified by crystallization.Type: GrantFiled: April 5, 2002Date of Patent: May 10, 2005Assignee: Tate & Lyle Public Limited CompanyInventors: Nicholas M. Vernon, Edward Micinski, Steven J. Catani, Juan L. Navia
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Publication number: 20040220398Abstract: A crystalline form of sucralose, and a method of making it. The method involves continuously crystallizing sucralose from an aqueous solution by a process providing continuous removal and recirculation of the vessel contents, and providing a long residence time for sucralose in the system. The crystals thus formed are of a relatively low length/diameter ratio, have an unsymmetrical shape, and exhibit good stability. The larger crystals in particular are tapered as compared to the rod-like larger crystals in prior art product.Type: ApplicationFiled: April 30, 2003Publication date: November 4, 2004Inventors: Steven J. Catani, Carolyn M. Merkel, Nicholas M. Vernon
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Publication number: 20040030124Abstract: This invention relates to a crystallization process for sucralose in which a mother liquor is obtained by separating crystalline sucralose from the remaining liquid. A portion of this mother liquor is returned to the same crystallization stage; the amount returned is adjusted so as to maintain the overall related substances level in the process below levels at which yield declines significantly.Type: ApplicationFiled: August 6, 2002Publication date: February 12, 2004Inventors: Steven J. Catani, Mark R. Huber, Nicholas M. Vernon
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Publication number: 20030190395Abstract: The present invention relates to novel methods for stabilizing aqueous deacylation, via use of buffers in the production of sucralose. The present invention provides a process for producing sucralose from an acyl-sucralose compound whereby the acyl-sucralose compound is deacylated in the presence of a buffering agent, which stabilizes the pH of the feed mixture and decreases the accumulation of undesired anhydro compounds. Further, the present invention provides a process whereby the acyl-sucralose compound is deacylated directly either prior to or after removal of the tertiary amide reaction vehicle from the neutralized chlorination feed mixture. An aqueous solution of sucralose including salts and other compounds is produced, from which sucralose is recovered by extraction and purified by crystallization.Type: ApplicationFiled: April 5, 2002Publication date: October 9, 2003Inventors: Nicholas M. Vernon, Edward Micinski, Steven J. Catani, Juan L. Navia
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Publication number: 20030171574Abstract: The present invention relates to novel extractive methods for purifying sucralose. The present invention also relates to compositions comprising the sucralose preparations made by the methods of the present invention.Type: ApplicationFiled: March 8, 2002Publication date: September 11, 2003Inventors: Steven J. Catani, Nicholas M. Vernon, David Saul Neiditch, James Edwin Wiley, Edward Micinski
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Publication number: 20030171575Abstract: This invention relates to processes for purifying sucralose by the use of an initial non-crystallization purification procedure followed by three or more sequential crystallization steps and recycle of the mother liquor remaining from each crystallization step to the feed of another crystallization or purification step. This invention also relates to sucralose compositions as well as compositions comprising the sucralose compositions of the present invention. These compositions may be highly pure and have a superior taste profile.Type: ApplicationFiled: March 8, 2002Publication date: September 11, 2003Inventors: Steven J. Catani, James E. Wiley, Nicholas M. Vernon, Carolyn M. Merkel, Edward Micinski
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Patent number: 5498709Abstract: There is disclosed a process for producing sucralose from sucralose-6-ester whereby the sucralose-6-ester is deacylated directly either prior to or after removal of the tertiary amide reaction vehicle from the neutralized chlorination reaction mixture, to produce an aqueous solution of sucralose plus salts and impurities, from which sucralose is recovered by extraction and is then preferably purified by crystallization.Type: GrantFiled: May 24, 1995Date of Patent: March 12, 1996Assignee: McNeil-PPC, Inc.Inventors: Juan L. Navia, Robert E. Walkup, Nicholas M. Vernon, David S. Neiditch
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Patent number: 5470969Abstract: Sucrose is mono-acylated in the 6-position by reacting sucrose with a carboxylic acid anhydride such as acetic or benzoic anhydride in a reaction mixture containing a polar aprotic solvent and a catalytic quantity of a 1,3-diacyloxy-1,1,3,3-tetra(hydrocarbyl)distannoxane, for a period of time and at a temperature sufficient to produce a sucrose-6-ester.Type: GrantFiled: May 2, 1994Date of Patent: November 28, 1995Assignee: McNeil-PPC, Inc.Inventors: George H. Sankey, Nicholas M. Vernon, Robert E. Wingard, Jr.
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Patent number: 5298611Abstract: A process for producing substantially pure sucralose pentaester from a mixture of 6-O-acyl-4,1' ,6' -trichloro-4,1',6'-trideoxygalactosucrose in a reaction medium comprising a tertiary amide, wherein said process comprises the steps of:(a) recovering the 6-O-acyl-4,1' ,6' -trichloro-4,1' ,6' -trideoxygalactosucrose from said mixture;(b) peracylating the 6-O-acyl-4,1' ,6' -trichloro-4,1' ,6' -trideoxygalactosucrose product of step (a) to produce thereby 4,1',6' -trichloro-4,1' ,6' -trideoxygalactosucrose pentaester; and(c) crystallizing the 4,1',6' -trichloro-4,1' ,6' -trideoxygalactosucrose pentaester product of step (b) to produce substantially pure 4,1',6' -trichloro-4,1' ,6' -trideoxygalactosucrose pentaester.Type: GrantFiled: March 12, 1993Date of Patent: March 29, 1994Assignee: McNeil-PPC, Inc.Inventors: Juan L. Navia, Robert E. Walkup, Nicholas M. Vernon, Robert E. Wingard, Jr.
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Patent number: 5136031Abstract: A process for the chlorination of sucrose or a derivative thereof, comprises reaction of the sucrose or derivative thereof with thionyl chloride and a nitrogen base at a ratio of about 1 molar equivalent (ME) of thionyl chloride and about 1 ME of base for every ME of free hydroxyl, in a non-reactive moderately polar solvent. The process is particularly suitable for the preparation of sucralose.Type: GrantFiled: July 9, 1990Date of Patent: August 4, 1992Assignee: Tate & Lyle Public Limited CompanyInventors: Riaz A. Khan, George H. Sankey, Philip J. Simpson, Nicholas M. Vernon
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Patent number: 5089608Abstract: There is disclosed a process which comprises the steps of:(a) reacting a di(hydrocarbyl)tin oxide such as a dialkyltin oxide with a dihydric alcohol, alkanolamine, or an enolizable .alpha.-hydroxyketone in an inert organic reaction vehicle, with removal of water, at a temperature and for a period of time sufficient to produce a cyclic adduct of said dialkyltin oxide and said dihydric alcohol, alkanolamine, or enolizable .alpha.-hydroxyketone;(b) reacting said cyclic adduct product of Step (a) with sucrose in an inert organic reaction vehicle such as a dipolar aprotic liquid, at a temperature and for a period of time sufficient to produce a 6-O-[dihydrocarbyl(hydroxy- or amino- or oxohydrocarbyl)stannoxyl]sucrose; and(c) reacting the product of Step (b) with an acylating agent to produce a sucrose-6-ester.Type: GrantFiled: March 23, 1990Date of Patent: February 18, 1992Assignee: McNeil-PPC, Inc.Inventors: Robert E. Walkup, Nicholas M. Vernon, Robert E. Wingard, Jr.
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Patent number: 5034551Abstract: A process which comprises extracting 1,3-diacyloxy-1,1,3,3-tetra(hydrocarbyl) distannoxane from a mixture containing 1,3-diacyloxy-1,1,3,3-tetra(hydrocarbyl)distannoxane, a sucrose-6-ester, and polar aprotic solvent, which process comprises the steps of:(a) contacting said mixture, in the presence of a small amount of water, with an organic solvent that is substantially immiscible with water to form thereby an extraction mixture, wherein the amount of water employed is sufficient to cause efficient partitioning of said 1,3-diacyloxy-1,1,3,3-tetra(hydrocarbyl)distannoxane from a first phase comprising said polar aprotic solvent into second phase comprising said organic solvent;(b) agitating the extraction mixture for a period of time and at a temperature sufficient to form thereby a two-phase mixture wherein the preponderance of the 1,3-diacyloxy-1,1,3,3-tetra(hydrocabyl)distannoxane in the extraction mixture is contained in said second phase and essentially all of the sucrose-6-ester in the extraction mixtureType: GrantFiled: April 23, 1990Date of Patent: July 23, 1991Assignee: Noramco, Inc.Inventors: Nicholas M. Vernon, Robert E. Walkup
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Patent number: 5023329Abstract: Process which comprises reacting sucrose with a di-(hydrocarbyl)tin oxide in an inert organic reaction vehicle with removal of water for a period of time and at a temperature sufficient to produce a 1,3-di-(6-O-sucrose)-1,1,3,3-tetra(hydrocarbyl)distannoxane.Type: GrantFiled: April 23, 1990Date of Patent: June 11, 1991Assignee: Noramco, Inc.Inventors: David S. Neiditch, Nicholas M. Vernon, Robert E. Wingard, Jr.
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Patent number: 4980463Abstract: A process for the chlorination of sucrose-6-esters to produce 6',4,1'-trichlorosucrose-6-esters which comprises the steps of:(a) adding at least seven molar equivalents of an acid chloride to a reaction mixture containing a sucrose-6-ester and a tertiary amide to form initially a chloroformiminium chloride salt which subsequently forms a complex with the hydroxyl groups of the sucrose-6-ester;(b) subjecting the reaction mixture product of step (a) to an elevated temperature not higher than about 85.degree. C. for a period of time sufficient to produce a mixture of chlorinated sucrose-6-ester products consisting essentially of 6'-chlorosucrose-6-ester, 4,6'-dichlorosucrose-6-ester, and 1',6'-dichlorosucrose-6-ester; and(c) subjecting the reaction mixture product of step (b) to an elevated temperature not higher than about 125.degree. C. for a period of time sufficient to produce a chlorinated product consisting essentially of 1',4,6'-trichlorosucrose-6-ester.Type: GrantFiled: July 18, 1989Date of Patent: December 25, 1990Assignee: Noramco, Inc.Inventors: Robert E. Walkup, Juan L. Navia, Nicholas M. Vernon
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Patent number: 4801700Abstract: A process for the preparation of 1,6-dichloro-1,6-dideoxy-.beta.-D-fructofuranosyl-4-chloro-4-deoxy-.alpha. -galactopyranoside comprising the steps of (a) reacting sucrose with a tritylating agent; (b) acetylating the tritylated reaction product; (c) detritylating the acetylated reaction product; (d) isomerizing the resulting penta-acetate; (e) chlorinating the isomerized product; and (f) deacetylating the chlorinated reaction product.Type: GrantFiled: October 20, 1986Date of Patent: January 31, 1989Assignee: McNeilab, Inc.Inventors: William Tully, Nicholas M. Vernon, Peter A. Walsh