Patents by Inventor Nicholas Mantis

Nicholas Mantis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR ENHANCING AN IMMUNE RESPONSE TO AN ANTIGEN
    Publication number: 20150366963
    Abstract: Provided are methods and kits for enhancing an immune response to an antigen in an individual comprising administering to the individual an effective amount of (a) LT-IIb or (b) LT-IIb(T13I) enterotoxin, and (c) an antigen, whereby the LT-IIb or LT-IIb(T13I) enterotoxin acts as an adjuvant to enhance the generation of antigen specific neutralizing antibodies.
    Type: Application
    Filed: February 6, 2014
    Publication date: December 24, 2015
    Inventors: Terry D. CONNELL, Nicholas MANTIS, Christopher GREENE
  • Fusion protein construct and method for inducing HIV-specific serum IgG and secretory IgA antibodies in-vivo
    Patent number: 7262270
    Abstract: The present invention provides a fusion protein construct (gp41HA) consisting of the ectodomain of the HIV-1IIIB envelope glycoprotein gp41 fused to a fragment of the influenza virus HA2 hemagglutinin protein. Immunization in-vivo via an intraperitoneal prime followed by intranasal or intragastric boosts with gp41HA induces high concentrations of serum IgG antibodies and fecal IgA antibodies that reacted with gp41 in HIV-1IIIB viral lysate and are cross-reactive with gp41 in HIV-1MN lysate. Followup analyses by indirect immunofluorescence showed that both serum IgG and fecal IgA recognized human peripheral blood mononuclear cells infected with either syncytium-inducing (SI) or non-syncytium-inducing (NSI) North American HIV-1 field isolates, but not uninfected cells.
    Type: Grant
    Filed: September 5, 2003
    Date of Patent: August 28, 2007
    Assignee: Children's Medical Center Corporation
    Inventors: Winfried Weissenhorn, David Prashker, legal representative, Nicholas Mantis, Marian R. Neutra, Pamela Kozlowski, Don Wiley, deceased
  • Fusion protein construct and method for inducing HIV-specific serum IgG and secretory IgA antibodies in-vivo
    Publication number: 20040096458
    Abstract: The present invention provides a fusion protein construct (gp41HA) consisting of the ectodomain of the HIV-1IIIB envelope glycoprotein gp41 fused to a fragment of the influenza virus HA2 hemagglutinin protein. Immunization in-vivo via an intraperitoneal prime followed by intranasal or intragastric boosts with gp41HA induces high concentrations of serum IgG antibodies and fecal IgA antibodies that reacted with gp41 in HIV-1IIIB viral lysate and are cross-reactive with gp41 in HIV-1MN lysate. Follow up analyses by indirect immunofluorescence showed that both serum IgG and fecal IgA recognized human peripheral blood mononuclear cells infected with either syncytium-inducing (SI) or non-syncytium-inducing (NSI) North American HIV-1 field isolates, but not uninfected cells.
    Type: Application
    Filed: September 5, 2003
    Publication date: May 20, 2004
    Inventors: Winfried Weissenhorn, Don Wiley, Nicholas Mantis, Marian R. Neutra, Pamela Kozlowski