Abstract: A fastener assembly for releasable interconnecting two objects comprises a retainer having means at the top end for attaching the retainer to a first object and an end wall at the bottom end having an aperture. A post affixed to a second object at its bottom end is captured within a central cavity of the retainer by resilient snap fit wherein either the post or the retainer is radially deflectable. A locking element slidably connected to the retainer is axially moveable between locked and unlocked positions operative to restrict the relative radial movement of the post and the retainer to prevent the removal of the post. The locking element maybe a pin moved by a magnet and extendable into a bore of the post by a spring. Alternatively, the locking element may be a sleeve closely fitted around the outside of the retainer.

Abstract: The present invention provides engineered ketoreductase and phosphite dehydrogenase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase and phosphite dehydrogenase enzymes, as well as polynucleotides encoding the engineered ketoreductase and phosphite dehydrogenase enzymes, host cells capable of expressing the engineered ketoreductase and phosphite dehydrogenase enzymes, and methods of using the engineered ketoreductase and phosphite dehydrogenase enzymes to synthesize a chiral catalyst used in the synthesis of antiviral compounds, such as nucleoside inhibitors. The present invention further provides methods of using the engineered enzymes to deracemize a chiral alcohol in a one-pot, multi-enzyme system.

Abstract: The present invention provides engineered phosphopentomutase (PPM) enzymes, polypeptides having PPM activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PPM enzymes are also provided. The present invention further provides compositions comprising the PPM enzymes and methods of using the engineered PPM enzymes. The present invention finds particular use in the production of pharmaceutical compounds.

Abstract: A fastener assembly for releasable interconnecting two objects includes a retainer having a top end for attaching the retainer to a first object and an end wall at the bottom end having an aperture. A post affixed to a second object at its bottom end is captured within a central cavity of the retainer by resilient snap fit wherein either the post or the retainer is radially deflectable. A locking element slidably connected to the retainer is axially moveable between locked and unlocked positions operative to restrict the relative radial movement of the post and the retainer to prevent the removal of the post. The locking element maybe a pin moved by a magnet and extendable into a bore of the post by a spring. Alternatively, the locking element may be a sleeve closely fitted around the outside of the retainer.

Abstract: The present invention provides engineered phosphopentomutase (PPM) enzymes, polypeptides having PPM activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PPM enzymes are also provided. The present invention further provides compositions comprising the PPM enzymes and methods of using the engineered PPM enzymes. The present invention finds particular use in the production of pharmaceutical compounds.

Abstract: The present invention provides engineered ketoreductase and phosphite dehydrogenase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase and phosphite dehydrogenase enzymes, as well as polynucleotides encoding the engineered ketoreductase and phosphite dehydrogenase enzymes, host cells capable of expressing the engineered ketoreductase and phosphite dehydrogenase enzymes, and methods of using the engineered ketoreductase and phosphite dehydrogenase enzymes to synthesize a chiral catalyst used in the synthesis of antiviral compounds, such as nucleoside inhibitors. The present invention further provides methods of using the engineered enzymes to deracemize a chiral alcohol in a one-pot, multi-enzyme system.

Abstract: A fastener assembly for releasable interconnecting two objects comprises a retainer having means at the top end for attaching the retainer to a first object and an end wall at the bottom end having an aperture. A post affixed to a second object at its bottom end is captured within a central cavity of the retainer by resilient snap fit wherein either the post or the retainer is radially deflectable. A locking element slidably connected to the retainer is axially moveable between locked and unlocked positions operative to restrict the relative radial movement of the post and the retainer to prevent the removal of the post. The locking element maybe a pin moved by a magnet and extendable into a bore of the post by a spring. Alternatively, the locking element may be a sleeve closely fitted around the outside of the retainer.

Abstract: Methods and compositions related to the use of a protein with kynureninase activity are described. For example, in certain aspects there may be disclosed a modified kynureninase capable of degrading kynurenine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with kynurenine depletion using the disclosed proteins or nucleic acids.

Abstract: A product for incorporating ultraviolet radiation protection and antimicrobial protection into a synthetic polymer is disclosed which has a quantity of zinc oxide particles modified with a layer of a reactive group that forms a bond with a quantity of synthetic polymer chips having C—H bonds. A product for incorporating ultraviolet radiation protection and antimicrobial protection into a synthetic polymer prior to forming a synthetic material is also disclosed which has a quantity of synthetic polymer chips and a quantity of zinc oxide particles modified with a layer of a reactive group that forms a bond with the quantity of the synthetic polymer chips.

Abstract: A product for incorporating ultraviolet radiation protection and antimicrobial protection into a synthetic polymer is disclosed which has a quantity of zinc oxide particles with each particle having a surface, a paste, a quantity of synthetic polymer chips, and a quantity of a reactive group for modifying each surface of each zinc oxide particle, the quantity of the reactive group sufficient for forming a bond with the quantity of synthetic polymer chips prior to the quantity of synthetic polymer chips being formed into a fiber.

Abstract: Methods and compositions related to the use of a protein with kynureninase activity are described. For example, in certain aspects there may be disclosed a modified kynureninase capable of degrading kynurenine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with kynurenine depletion using the disclosed proteins or nucleic acids.

Abstract: A product having ultraviolet radiation protection and antimicrobial protection has a quantity of synthetic material, a quantity of zinc oxide particles with each particle having a surface, the quantity of zinc oxide particles in the range of 0.05 percent to 0.10 percent, and a quantity of a reactive group for modifying each surface of each zinc oxide particle, the quantity of the reactive group for incorporating the quantity of zinc oxide particles into the quantity of synthetic material prior to the quantity of synthetic material being formed into a fiber.

Abstract: The present invention provides engineered phosphopentomutase (PPM) enzymes, polypeptides having PPM activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PPM enzymes are also provided. The present invention further provides compositions comprising the PPM enzymes and methods of using the engineered PPM enzymes. The present invention finds particular use in the production of pharmaceutical compounds.

Abstract: The present invention provides engineered ketoreductase and phosphite dehydrogenase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase and phosphite dehydrogenase enzymes, as well as polynucleotides encoding the engineered ketoreductase and phosphite dehydrogenase enzymes, host cells capable of expressing the engineered ketoreductase and phosphite dehydrogenase enzymes, and methods of using the engineered ketoreductase and phosphite dehydrogenase enzymes to synthesize a chiral catalyst used in the synthesis of antiviral compounds, such as nucleoside inhibitors. The present invention further provides methods of using the engineered enzymes to deracemize a chiral alcohol in a one-pot, multi-enzyme system.

Abstract: A product for incorporating ultraviolet radiation protection and antimicrobial protection into a synthetic polymer is disclosed which has a quantity of zinc oxide particles modified with a layer of a reactive group that forms a bond with a quantity of synthetic polymer chips having C—H bonds. A product for incorporating ultraviolet radiation protection and antimicrobial protection into a synthetic polymer prior to forming a synthetic material is also disclosed which has a quantity of synthetic polymer chips and a quantity of zinc oxide particles modified with a layer of a reactive group that forms a bond with the quantity of the synthetic polymer chips.

Abstract: The present invention provides engineered ketoreductase and phosphite dehydrogenase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase and phosphite dehydrogenase enzymes, as well as polynucleotides encoding the engineered ketoreductase and phosphite dehydrogenase enzymes, host cells capable of expressing the engineered ketoreductase and phosphite dehydrogenase enzymes, and methods of using the engineered ketoreductase and phosphite dehydrogenase enzymes to synthesize a chiral catalyst used in the synthesis of antiviral compounds, such as nucleoside inhibitors. The present invention further provides methods of using the engineered enzymes to deracemize a chiral alcohol in a one-pot, multi-enzyme system.

Abstract: A product for incorporating ultraviolet radiation protection and antimicrobial protection into a synthetic polymer is disclosed which has a quantity of zinc oxide particles modified with a layer of a reactive group that forms a bond with a quantity of synthetic polymer chips having C—H bonds. A product for incorporating ultraviolet radiation protection and antimicrobial protection into a synthetic polymer prior to forming a synthetic material is also disclosed which has a quantity of synthetic polymer chips and a quantity of zinc oxide particles modified with a layer of a reactive group that forms a bond with the quantity of the synthetic polymer chips.