Patents by Inventor Nicholas Maughan Clayton

Nicholas Maughan Clayton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Benzo (f) isoindol-2-ylphenyl acetic acid derivatives as EPreceptor agonists
    Patent number: 8252833
    Abstract: A compound of formula (I) or a pharmaceutically acceptable derivative thereof, wherein, R1 R2 R3, R4, R5, R6, X and Y are as defined in the specification; a process for preparing such compounds; a pharmaceutical composition comprising such compounds; and the use of such compounds in medicine.
    Type: Grant
    Filed: February 1, 2007
    Date of Patent: August 28, 2012
    Assignee: Glaxo Group Limited
    Inventors: Andrew Billinton, Nicholas Maughan Clayton, Gerard Martin Paul Giblin, Mark Patrick Healy
  • BENZO (F) ISOINDOL-2-YLPHENYL ACETIC ACID DERIVATIVES AS EP4 RECEPTOR AGONISTS
    Publication number: 20110201663
    Abstract: A compound of formula (I) or a pharmaceutically acceptable derivative thereof, wherein, R1 R2 R3, R4, R5, R6, X and Y are as defined in the specification; a process for preparing such compounds; a pharmaceutical composition comprising such compounds; and the use of such compounds in medicine.
    Type: Application
    Filed: February 1, 2007
    Publication date: August 18, 2011
    Inventors: Andrew Billinton, Nicholas Maughan Clayton, Gerard Martin Paul Giblin, Mark Patrick Healy
  • Use of EP4 receptor ligands in the treatment of neuropathic pain and colon cancer
    Patent number: 6861441
    Abstract: The present invention relates to the use of an EP4 receptor ligand in the manufacture of a medicament for use in the treatment of neuropathic pain, colon cancer, migraine, and for increasing the latency of HIV infection.
    Type: Grant
    Filed: August 8, 2000
    Date of Patent: March 1, 2005
    Assignee: SmithKline Beecham Corporation
    Inventors: Nicholas Maughan Clayton, Susanne Denise Collins, Steven Michael Foord, Gerard Martin Paul Giblin, Richard John Coles, Mark Bamford, Jennifer M Doughty, Richard Green
  • Formulations of adenosine a1 agonists
    Publication number: 20030018008
    Abstract: The present invention provides a method of treating conditions associated with pain and alleviating the symptoms associated therewith which comprises administering to a mammal, including man, an adenosine A1 agonist or a physiologically acceptable salt or solvate thereof and a 5HT3 antagonist or a physiologically acceptable salt or solvate thereof. The present invention also provides pharmaceutical formulations and patient packs comprising said combinations.
    Type: Application
    Filed: June 18, 2002
    Publication date: January 23, 2003
    Inventors: Charanjit Bountra, Nicholas Maughan Clayton, Alan Naylor
  • Formulations of adenosine a1 agonists
    Publication number: 20030008842
    Abstract: The present invention provides a method of treating conditions associated with pain and alleviating the symptoms associated therewith which comprises administering to a mammal, including man, an adenosine A1 agonist or a physiologically acceptable salt or solvate thereof and a sodium channel blocker or a physiologically acceptable salt or solvate thereof. The present invention also provides pharmaceutical formulations and patient packs comprising said combinations.
    Type: Application
    Filed: June 18, 2002
    Publication date: January 9, 2003
    Inventors: Charanjit Bountra, Nicholas Maughan Clayton, Alan Naylor
  • Formulatios of adenosine a1 agonists
    Publication number: 20030004128
    Abstract: The present invention provides a method of treating conditions associated with pain and alleviating the symptoms associated therewith which comprises administering to a mammal, including man, an adenosine A1 agonist or a physiologically acceptable salt or solvate thereof and an NSAID, e.g. a COX-2 inhibitor, or a physiologically acceptable salt or solvate thereof. The present invention also provides pharmaceutical formulations and patient packs comprising said combinations.
    Type: Application
    Filed: June 18, 2002
    Publication date: January 2, 2003
    Inventors: Charanjit Bountra, Nicholas Maughan Clayton, Alan Naylor
  • Formulations of adenosine A1 agonists
    Publication number: 20030004126
    Abstract: The present invention provides a method of treating conditions associated with pain and alleviating the symptoms associated therewith which comprises administering to a mammal, including man, an adenosine A1 agonist or a physiologically acceptable salt or solvate thereof and an opioid or a physiologically acceptable salt or solvate thereof. The present invention also provides pharmaceutical formulations and patient packs comprising said combinations.
    Type: Application
    Filed: June 18, 2002
    Publication date: January 2, 2003
    Inventors: Charanjit Bountra, Nicholas Maughan Clayton, Alan Naylor
  • Formulations of adenosine a1 agonists
    Publication number: 20030004127
    Abstract: The present invention provides a method of treating conditions associated with pain and alleviating the symptoms associated therewith which comprises administering to a mammal, including man, an adenosine A1 agonist or a physiologically acceptable salt or solvate thereof and a 5HT1 receptor agonist or a physiologically acceptable salt or solvate thereof. The present invention also provides pharmaceutical formulations and patient packs comprising said combinations.
    Type: Application
    Filed: June 18, 2002
    Publication date: January 2, 2003
    Inventors: Charanjit Bountra, Nicholas Maughan Clayton, Alan Naylor
  • Formulations of adenosine a1 agonists
    Publication number: 20030004129
    Abstract: The present invention provides a method of treating conditions associated with pain and alleviating the symptoms associated therewith which comprises administering to a mammal, including man, (i) an adenosine A1 agonist or a physiologically acceptable salt or solvate thereof and (ii) gabapentin or pregabalin or a physiologically acceptable salt or solvate thereof. The present invention also provides pharmaceutical formulations and patient packs comprising said combinations.
    Type: Application
    Filed: June 18, 2002
    Publication date: January 2, 2003
    Inventors: Charanjit Bountra, Nicholas Maughan Clayton, Alan Naylor
  • Formulations of adenosine a1 agonists
    Publication number: 20020198170
    Abstract: The present invention provides a method of treating conditions associated with pain and alleviating the symptoms associated therewith which comprises administering to a mammal, including man, a adenosine A1 agonist or a physiologically acceptable salt or solvate thereof and an EP1 antagonist or a physiologically acceptable salt or solvate thereof. The present invention also provides pharmaceutical formulations and patient packs comprising said combinations.
    Type: Application
    Filed: June 18, 2002
    Publication date: December 26, 2002
    Inventors: Charanjit Bountra, Nicholas Maughan Clayton, Alan Naylor