Patents by Inventor Nicholas MINUTOLO

Nicholas MINUTOLO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • QUANTITATIVE CONTROL OF ACTIVITY OF ENGINEERED CELLS EXPRESSING SPYCATCHER AND SPYTAG UNIVERSAL IMMUNE RECEPTORS
    Publication number: 20230103327
    Abstract: The invention provides methods for stimulating a universal immune receptor-mediated response in a mammal using cells engineered to express a universal immune receptor that comprises an adaptor molecule, such as a SpyCatcher or a SpyTag moiety, a transmembrane domain, and an intracellular domain for T cell activation.
    Type: Application
    Filed: January 23, 2021
    Publication date: April 6, 2023
    Inventors: Daniel J. Powell, Jr., Andrew Tsourkas, Nicholas Minutolo
  • A DOTA binding chimeric antigen receptor for cellular therapy
    Publication number: 20220403051
    Abstract: The present invention includes compositions and methods that utilize a Universal Immune Receptor (UnivIR) CAR system comprising a modified T cell comprising a DOTA CAR and a DOTA-conjugated targeting ligand. In certain embodiments, the invention includes methods for treating, ameliorating, and/or preventing cancer. In certain embodiments, the invention provides a set of complementary molecular imaging tools that is applicable to CAR T cell therapy.
    Type: Application
    Filed: April 23, 2020
    Publication date: December 22, 2022
    Inventors: Daniel J. POWELL, Nicholas MINUTOLO, Michael FARWELL