Abstract: Wastewater processing modules that include an interior surface defining an interior volume, one or more inlets configured to receive wastewater into the interior volume, one or more outlets configured to exhaust processed water from the interior volume, one or more flow-deflecting baffles positioned within the interior volume fluidly between the inlet(s) and the outlet(s) and that divide the interior volume into a plurality of fluidly connected sections, and a purification medium at least partially filing the plurality of fluidly connected sections. The flow-deflecting baffle(s) are configured to channel the wastewater to flow along a plurality of circuitous bulk flow paths through the purification medium. The purification medium is configured to sequester contaminants from the wastewater as it flows through the interior volume along the circuitous bulk flow paths to produce the processed water therefrom.

Abstract: The present invention provides engineered ketoreductase and phosphite dehydrogenase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase and phosphite dehydrogenase enzymes, as well as polynucleotides encoding the engineered ketoreductase and phosphite dehydrogenase enzymes, host cells capable of expressing the engineered ketoreductase and phosphite dehydrogenase enzymes, and methods of using the engineered ketoreductase and phosphite dehydrogenase enzymes to synthesize a chiral catalyst used in the synthesis of antiviral compounds, such as nucleoside inhibitors. The present invention further provides methods of using the engineered enzymes to deracemize a chiral alcohol in a one-pot, multi-enzyme system.

Abstract: Information identifying a message scanning system is encoded into URLs. A document management system can decode the identifying information to verify that a document accessed via a URL was accessed by a trusted entity rather than by an unknown user. The document management system sends a message including a URL to access a document. When a message scanning system known to the document management system reviews the message for threats, it encodes its identity into a modified form of the URL in the message and uses the modified URL to access the resource. The document management system can decode the identity of the messaging system using a decoding key. Based on the identification, the document management system updates records associated with the document to include the document acce by the message scanning system.

Abstract: Systems and methods are provided for handling Personally Identifiable Information (PII) in a globally compliant manner, across and within governmental or defined synthetic jurisdictions without violating the privacy laws or rules of the involved jurisdictions. Disclosed systems for distributing PII include a regional server in a first jurisdiction with a first set of jurisdictional rules, a central computer and a recipient computer. The recipient computer is located in a second jurisdiction and inputs data conforming to a second set of jurisdictional rules. The central computer communicates with both the regional server and the recipient computer. The central computer masks data coming from the first jurisdiction and from the second jurisdiction so that the data complies with the rules of the destination jurisdiction.

Abstract: A method of manufacturing a custom foot orthotic for a patient is described. The method includes collecting dynamic pressure data of a plantar surface of the foot of the patient at multiple time frames during a gait cycle of the patient, determining the dimensions of the patient's foot from the dynamic pressure data, scaling a three dimensional model of a foot orthotic along the x and y axes to form a scaled three dimensional model which approximates the dimensions of the patient's foot and adjusting the height of the scaled model along the z-axis in one or more regions based on the dynamic pressure data to form a three-dimensional model of the custom foot orthotic. A method is also provided which includes creating a two-dimensional model of a custom foot orthotic from dynamic pressure data and extruding the two-dimensional model in one or more regions based on the dynamic pressure data to form a three-dimensional model of the custom foot orthotic. The orthotic can be manufactured using 3D printing.

Abstract: Systems and methods are provided for handling Personally Identifiable Information (PII) in a globally compliant manner, across and within governmental or defined synthetic jurisdictions without violating the privacy laws or rules of the involved jurisdictions. Disclosed systems for distributing PII include a regional server in a first jurisdiction with a first set of jurisdictional rules, a central computer and a recipient computer. The recipient computer is located in a second jurisdiction and inputs data conforming to a second set of jurisdictional rules. The central computer communicates with both the regional server and the recipient computer. The central computer masks data coming from the first jurisdiction and from the second jurisdiction so that the data complies with the rules of the destination jurisdiction.

Abstract: A system, method, and computer program for identifying evolving regions in a graph of interrelated nodes representing a computer system environment. The method includes generating a series of samples (302) of the environment. Each sample includes a plurality of interrelated nodes (502) and at least one edge (504) classified into a plurality of at least one of node type and edge type, respectively. A summary (900) of the plurality of at least one of node type (502) and edge type (504) is created for the series of samples (302). A summary instance (312) of the summary (900) is created for each sample. At least one summary instance (312) is compared to at least one subsequent summary instance (314) and at least one result (318) is stored in memory (106). A successive behavior is characterized for one or more of the at least one of the node type and the edge type.

Abstract: A pharmaceutical composition comprising a serotonin transport inhibitor and a 5-HT1D antagonist, together with a pharmaceutically acceptable diluent or carrier.

Abstract: Component mounting pads for multi-layer printed circuit boards encompass a smaller area than conventional pads, reducing parasitic capacitance between the pads and a ground plane layer. A number of such pads are arranged to accommodate standard surface-mount component sizes and packages. Further capacitance reductions are achieved by implementing mesh areas or apertures in the board's ground plane opposite the reduced-capacitance pads.