Patents by Inventor Nicholas Murgolo

Nicholas Murgolo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • C.difficile toxin B CROP domain peptides, antibodies and complexes thereof
    Patent number: 9181632
    Abstract: The present invention provides polypeptide domains of C. difficile toxin B (B1, B2, B3, B4) and complexes between the polypeptides and antibodies that bind specifically for the polypeptide. Methods of using the polypeptides to generate antibodies are also provided.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: November 10, 2015
    Assignee: MERCK SHARP & DOHME CORP.
    Inventors: Nicholas Murgolo, Lorraine Hernandez, Payal Sheth, Corey Strickland, Peter Orth, Alex Therien, Paul Reichert, Li Xiao
  • NPC1L1 (NPC3) and methods of use thereof
    Publication number: 20070021592
    Abstract: The present invention provides human, rat and mouse NPC1L1 polypeptides and polynucleotides encoding the polypeptides. Also provided are methods for detecting agonists and antagonists of NPC1L1. Inhibitors of NPC1L1 can be used for inhibiting intestinal cholesterol absorption in a subject.
    Type: Application
    Filed: September 19, 2006
    Publication date: January 25, 2007
    Inventors: Scott Altmann, Nicholas Murgolo, Luquan Wang, Michael Graziano
  • Humanized monoclonal antibodies against human interleukin-4
    Patent number: 5705154
    Abstract: Humanized monoclonal antibodies are provided which are specific for human IL-4 and have properties unexpectedly superior to other, previously available humanized antibodies. Single-chain binding proteins, fusion proteins, and antigenic or IL-4 binding fragments of such antibodies are also provided by this invention. Also provided are nucleic acids which encode the heavy and light chain variable regions of such monoclonal antibodies or antigenic fragments thereof; anti-idiotypic antibodies; and methods for detecting, measuring and immunopurifying human IL-4, and for blocking or mimicking the biological activity of human IL-4.
    Type: Grant
    Filed: September 6, 1996
    Date of Patent: January 6, 1998
    Assignee: Schering Corporation
    Inventors: Barbara Dalie, Kenneth Miller, Nicholas Murgolo, Stephen Tindall
  • Humanized monoclonal antibodies against human interleukin-4
    Patent number: 5597710
    Abstract: Humanized monoclonal antibodies are provided which are specific for human IL-4 and have properties unexpectedly superior to other, previously available humanized antibodies. Also provided are nucleic acids which encode the heavy and light chain variable regions of such monoclonal antibodies or antigenic fragments thereof; anti-idiotypic antibodies; and methods for detecting, measuring and immunopurifying human IL-4, and for blocking or mimicking the biological activity of human IL-4.
    Type: Grant
    Filed: March 10, 1994
    Date of Patent: January 28, 1997
    Assignee: Schering Corporation
    Inventors: Barbara Dalie, Kenneth Miller, Nicholas Murgolo, Stephen Tindall