Abstract: The present invention relates to novel blood-brain barrier (BBB) penetrable substituted bicyclic derivatives that can selectively inhibit ROCK2 and/or Rho-kinase mediated phosphorylation of myosin light chain phosphates, compositions comprising the derivatives, methods for preparing the derivatives and/or compositions, and methods for using the derivatives and/or compositions.

Abstract: A quick entry method includes receiving receive, at a device comprising a screen, a selection of a portion of a screen, which corresponds to a section of a regular form. A sectional data separation process is performed to identify and separate the section of the regular form into a plurality of individual questions. Each of the plurality of individual questions is formatted for the screen. The plurality of individual questions is displayed, one at a time, on the device comprising the screen. Each of the plurality of individual questions comprising one or more data input fields for a user to complete.

Abstract: According to some embodiments, a message display system comprises a processor and a non-transitory computer readable medium. The non-transitory computer readable medium comprises computer-readable instructions, that when executed by the processor, perform a method. The method comprises receiving a plurality of messages from a group of users. Each of the plurality of received messages is formatted to be displayed in a moving stream of messages, and an entire received message for each of the plurality of messages is displayed in a moving stream on a display screen.

Abstract: A quick entry method includes receiving receive, at a device comprising a screen, a selection of a portion of a screen, which corresponds to a section of a regular form. A sectional data separation process is performed to identify and separate the section of the regular form into a plurality of individual questions. Each of the plurality of individual questions is formatted for the screen. The plurality of individual questions is displayed, one at a time, on the device comprising the screen. Each of the plurality of individual questions comprising one or more data input fields for a user to complete.

Abstract: A focused screen data field presentation system and a focused screen data field presentation method are disclosed for entry of data associated with an electronic form into a quick entry system (CUES). The focused screen data field presentation system supports and the focused screen data field presentation d provides an efficient and effect manner of form entry that supersedes existing conventional electronic form systems and old traditional methods of form entry for websites, mobile devices, computers, and other electronic systems.

Abstract: The invention provides methods of monitoring differential gene expression of biomarkers to determine patient sensitivity to Wnt inhibitor, methods of determining the sensitivity of a cell to an Wnt inhibitor by measuring biomarkers, methods of screening for candidate Wnt inhibitor, Wnt inhibitor for use in head and neck squamous cell carcinoma.

Abstract: Disclosed are biomarkers, methods and assay for the identification of cancer patients who are predicted to benefit from the therapeutic administration of Wnt antagonist. The biomarkers include detection of RNF43 and ZNRF3 gene deletion, reduced RNF43 and ZNRF3 mRNA expression, reduced RNF43 and ZNRF3 protein expression, RNF43 and ZNRF3 inactivation mutation, phosphorylated LRP6, phophorylated Dishevelleds, and the expression of Frizzleds. These biomarkers can be associated with the better outcome for cancer patients treated with Wnt pathway inhibitors.

Abstract: A mobile platform includes an antenna adapted to simultaneously transmit on a first channel and receive on a second channel, and to dynamically switch communication channels as needed. For example, as the mobile platform changes position, orientation, etc., the configuration of the antenna may be updated to transmit on the second channel and receive on the first channel. Accordingly, despite changes in position or orientation, the mobile platform may maintain communication with other mobile platforms, ground controllers, user equipment, etc.

Abstract: Disclosed are biomarkers, methods and assay for the identification of cancer patients who are predicted to benefit from the therapeutic administration of Wnt antagonist. The biomarkers include detection of RNF43 and ZNRF3 gene deletion, reduced RNF43 and ZNRF3 mRNA expression, reduced RNF43 and ZNRF3 protein expression, RNF43 and ZNRF3 inactivation mutation, phosphorylated LRP6, phophorylated Dishevelleds, and the expression of Frizzleds. These biomarkers can be associated with the better outcome for cancer patients treated with Wnt pathway inhibitors.

Abstract: The invention discloses several types of fastener, fastening systems, fastener assemblies and related areas. In particular, the invention relates to a releasable fastening system (50) which has a pin (152) with a locking cavity (163). The pin is intended for insertion in an aperture (154). A locking means (158, 160) engages the locking cavity (163) of the pin (152) when the pin (152) is received in the aperture (154). The system (150) also includes unlocking means (162) which includes material adapted to contract when activated. When a material contracts, engagement means (158) included in the locking means (158, 160), disengage the locking cavity (154).

Abstract: The invention discloses several types of fastener, fastening systems, fastener assemblies and related areas. In particular, the invention relates to a releasable fastening system (150) which has a pin (152) with a locking cavity (163). The pin is intended for insertion in an aperture (154). A locking means (158, 160) engages the locking cavity (163) of the pin (152) when the pin (152) is received in the aperture (154), The system (150) also includes unlocking means (162) which includes material adapted to contract when activated. When a material contracts, engagement means (158) included in the locking means (158, 160), disengage the locking cavity (154).

Abstract: A method for selecting a global positioning receiver includes receiving global positioning system signals from global positioning system receivers. The global positioning system receivers receive the global positioning system signals from corresponding global positioning system satellites. The method also includes replicating the global positioning system signals from the global positioning system receivers, determining a signal drift and a phase precision for each global positioning system signal, and selecting one of the global positioning system signals based on the corresponding signal drift and the phase precision of the global positioning system signal.

Abstract: A method for selecting a global positioning receiver includes receiving global positioning system signals from global positioning system receivers. The global positioning system receivers receive the global positioning system signals from corresponding global positioning system satellites. The method also includes determining a signal quality score of each received signal based on a signal drift and a phase precision of the corresponding signal, and selecting one of the received global positioning system signals having the highest signal quality score.

Abstract: A cascaded distribution framework includes a global positioning system receiver in communication with optical line terminals. Each global positioning system receiver receives a signal from a corresponding global positioning system satellite. Each optical line terminal includes a management card for each global positioning system receiver in communication with the optical line terminal and a line card. The management card receives a global positioning system signal from a corresponding global positioning system receiver. The line card is collocated for each management card in the optical line terminal. Each line card receives a global positioning system signal from each management card in the optical line terminal, determines a signal quality score of each received signal based on a signal drift and a phase precision of the corresponding signal, and selects one of the received global positioning system signals having the highest signal quality score.

Abstract: A signal distribution system includes global positioning system receivers in communication with optical line terminals and a system manager. Each global positioning system receiver receives a signal from a corresponding global positioning system satellite. Each optical line terminal includes a management card and a line card. The management card receives a signal from a corresponding global positioning system receiver. Each line card receives a signal from each management card and determines a signal drift and a phase precision for each signal. The system manager receives a failure communication for a global positioning system signal from a line card when the signal drift of the global positioning system signal is above a threshold signal drift or the phase precision of the signal is below a threshold phase precision. The system manager identifies a failure location of the signal within the system based on one or more received failure communications.

Abstract: The invention provides methods of monitoring differential gene expression of biomarkers to determine patient sensitivity to Wnt inhibitor, methods of determining the sensitivity of a cell to an Wnt inhibitor by measuring biomarkers, methods of screening for candidate Wnt inhibitor, Wnt inhibitor for use in head and neck squamous cell carcinoma.

Abstract: Disclosed are biomarkers, methods and assay for the identification of cancer patients who are predicted to benefit from the therapeutic administration of Wnt antagonist. The biomarkers include detection of RNF43 and ZNRF3 gene deletion, reduced RNF43 and ZNRF3 mRNA expression, reduced RNF43 and ZNRF3 protein expression, RNF43 and ZNRF3 inactivation mutation, phosphorylated LRP6, phophorylated Dishevelleds, and the expression of Frizzleds. These biomarkers can be associated with the better outcome for cancer patients treated with Wnt pathway inhibitors.

Abstract: The invention discloses several types of fastener, fastening systems, fastener assemblies and related areas. In particular, the invention relates to a releasable fastening system (150) which has a pin (152) with a locking cavity (163). The pin is intended for insertion in an aperture (154). A locking means (158, 160) engages the locking cavity (163) of the pin (152) when the pin (152) is received in the aperture (154), The system (150) also includes unlocking means (162) which includes material adapted to contract when activated. When a material contracts, engagement means (158) included in the locking means (158, 160), disengage the locking cavity (154).

Abstract: The invention discloses several types of fastener, fastening systems, fastener assmeblies and related areas. In particular, the invention discloses a releasable fastening system (150) which has a pin (152) with a locking cavity (163). The pin is intended for insertion in an aperture (154). A locking means (158, 160) engages the locking cavity (163) of the pin (152) when the pin (152) is received in the aperture (154). The system (150) also includes unlocking means (162) which includes material adapted to contract when activated. When a material contracts, engagement means (158) included in the locking means (158, 160), disengage the locking cavity (154).

Abstract: Quick release bolt assembly included shank and head of larger cross-section than that of shank. The screw thread of shank is adapted to rotatably engage with a complementary screw thread in a nut. Disengagement means are adapted in use to disengage the head or the nut without rotation of the nut or shank. The disengagement means includes a material such as shape memory alloy or epoxy resin, adapted to change form to facilitate engagement when activated. Activation may take place by a direct power supply or remotely by a radio frequency, magnetic, ultrasonic or infra red signal. Bolt can be used for anchoring seat belts. Computer systems and methods for the identification of a target, including enquiring as to the status of the target and having means to command the target to change the status are also disclosed and claimed.