Patents by Inventor Nicholas Nikolaides

Nicholas Nikolaides has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 6-[(4,5-Dihydro-1H-imidazol-2-yl)amino]-7-methyl-1H-benzimidazole-4-carbonitrile and its preferred salt
    Patent number: 7304084
    Abstract: 6-[(4,5-Dihydro-1H-imidazol-2-yl)amino-]-7-methyl-1H-benzimidazole-4-carbonitrile substantially free of 2,3,7-triamino-4,6-dimethyl-1,9-phenazinedicarbonitrile, and the anhydrous monoacetate salt thereof, are useful in the treatment of alpha-2 mediated disorders such as ocular hypertension.
    Type: Grant
    Filed: January 17, 2006
    Date of Patent: December 4, 2007
    Assignee: The Board of Regents of the University of Nebraska
    Inventors: Jared Lynn Randall, Richard Alan Gibbs, Gregory Kent Bosch, Michael David Curtis, Li Sun, Nicholas Nikolaides
  • Methods of making 6-[(4,5-dihydro-1H-imidazol-2-yl)amino-]-7-methyl-1H-benzimidazole-4-carbonitrile and its preferred salt form
    Publication number: 20060122248
    Abstract: 6-[(4,5-Dihydro-1H-imidazol-2-yl)amino-]-7-methyl-1H-benzimidazole-4-carbonitrile substantially free of 2,3,7-triamino-4,6-dimethyl-1,9-phenazinedicarbonitrile, and the anhydrous monoacetate salt thereof, are useful in the treatment of alpha-2 mediated disorders such as ocular hypertension.
    Type: Application
    Filed: January 17, 2006
    Publication date: June 8, 2006
    Inventors: Jared Randall, Richard Gibbs, Gregory Bosch, Michael Curtis, Li Sun, Nicholas Nikolaides
  • Methods of making 6-[(4,5-Dihydro-1H-imidazol-2-yl)amino-]-7-methyl-1H-benzimidazole-4-carbonitrile and its preferred salt form
    Publication number: 20040167194
    Abstract: 6-[(4,5-Dihydro-1H-imidazol-2-yl)amino-]-7-methyl-1H-benzimidazole-4-carbonitrile substantially free of 2,3,7-triamino-4,6-dimethyl-1,9-phenazinedicarbonitrile, and the anhydrous monoacetate salt thereof, are useful in the treatment of alpha-2 mediated disorders such as ocular hypertension.
    Type: Application
    Filed: March 12, 2003
    Publication date: August 26, 2004
    Inventors: Jared Lynn Randall, Richard Alan Gibbs, Gregory Kent Bosch, Michael David Curtis, Li Sun, Nicholas Nikolaides
  • 2-CARBOXAMIDE-BENZIMIDAZOLES USEFUL IN THE TREATMENT AND PREVENTION OF ISCHEMIC REPERFUSION INJURY
    Publication number: 20030216582
    Abstract: The subject invention relates to compounds having the structure: (I) wherein: (a) R1 is selected from the group consisting of alkyl, aryl, alkoxy, and aryloxy, the alkyl and aryl portions of preferred R1 having from 1 to about 14 carbon atoms; (b) R3 and R4 are independently selected from the group consisting of hydrogen, halo, alkyl, alkoxy, alkyl-aryloxy, alkylthio, amino, and mono- or dialkylaminio, the alkyl portions of preferred R3 and R4 having from 1 to about 8 carbon atoms; except that R3 and R4 are not both hydrogen; (c) each R5 is independently selected from the group consisting of hydrogen, halo, cyano, alkyl, hydroxy, alkoxy, thio, alkylthio, amino, and mono- or dialkylamino, the alkyl portions of preferred R5 having from 1 to about 8 carbon atoms. The subject invention further relates to compositions comprising these compound. The subject compounds are useful for preventing or treating reperfusion injury of a variety of tissues.
    Type: Application
    Filed: August 7, 2002
    Publication date: November 20, 2003
    Inventors: Nicholas Nikolaides, Donatella Chianelli
  • 2-phencycarbamoyl-benzimidazoles
    Publication number: 20030087943
    Abstract: 1
    Type: Application
    Filed: August 7, 2002
    Publication date: May 8, 2003
    Inventors: Nicholas Nikolaides, Donatella Chianelli