Patents by Inventor Nicholas Obiri

Nicholas Obiri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IL-13 receptor specific chimeric proteins & uses thereof
    Publication number: 20030129132
    Abstract: The present invention provides a method and compositions for specifically delivering an effector molecule to a tumor cell. The method involves providing a chimeric molecule that comprises an effector molecule attached to a targeting molecule that specifically binds an IL-13 receptor and contacting a tumor cell with the chimeric molecule.
    Type: Application
    Filed: December 13, 2002
    Publication date: July 10, 2003
    Applicant: The Government of the USA as represented by the Secretary of the Dept. of Health & Human Services
    Inventors: Raj K. Puri, Waldemar Debinski, Ira Pastan, Nicholas Obiri
  • IL-13 receptor specific chimeric proteins and uses thereof
    Patent number: 6518061
    Abstract: The present invention provides a method and compositions for specifically delivering an effector molecule to a tumor cell bearing an IL-13 receptor. The method involves providing a chimeric molecule that comprises an effector molecule attached to a circularly permuted IL-13 (“cpIL-13”) that specifically binds an IL-13 receptor and contacting the tumor cell with the chimeric molecule. The compositions include chimeric molecules comprising effector molecules such as modified Pseudomonas exotoxin attached to a cpIL-13. The invention further provides vectors encoding the chimeric molecules.
    Type: Grant
    Filed: February 17, 1998
    Date of Patent: February 11, 2003
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Raj K. Puri, Waldemar Debinski, Ira Pastan, Nicholas Obiri
  • IL-13 receptor specific chimeric proteins
    Patent number: 5919456
    Abstract: This invention provides chimeric molecules useful for killing tumor cells bearing IL13 receptor(s) (IL-13R). The molecules comprise a cytotoxic molecule attached to a targeting molecule that specifically binds an IL-13 receptor. Preferred targeting molecules include IL-13 and anti-IL-13R antibodies.
    Type: Grant
    Filed: March 21, 1997
    Date of Patent: July 6, 1999
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Raj K. Puri, Waldemar Debinski, Ira Pastan, Nicholas Obiri
  • IL-13 receptor specific chimeric proteins and uses thereof
    Patent number: 5614191
    Abstract: The present invention provides a method and compositions for specifically delivering an effector molecule to a tumor cell. The method involves providing a chimeric molecule that comprises an effector molecule attached to a targeting molecule that specifically binds an IL-13 receptor and contacting a tumor cell with the chimeric molecule.
    Type: Grant
    Filed: March 15, 1995
    Date of Patent: March 25, 1997
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Raj K. Puri, Waldemar Debinski, Ira Pastan, Nicholas Obiri