Patents by Inventor Nicholas P. Farrell

Nicholas P. Farrell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Transplatinum complexes with NOdonor sets as cytotoxic and antitumor agents
    Patent number: 8324197
    Abstract: Trans-platinum compounds comprising carboxylato groups are disclosed, with anti-cancer usefulness. The carboxylato groups participate in solubilizing trans-platinum compounds to which they are attached.
    Type: Grant
    Filed: August 11, 2006
    Date of Patent: December 4, 2012
    Assignee: Virginia Commonwealth University
    Inventor: Nicholas P. Farrell
  • Bis-platinum complexes with polymethylene derivatives as ligands having antitumor activity
    Patent number: 6060616
    Abstract: Bis-platinum(II) complexes with polymethylene derivatives, the method of making the complexes, and the use of the complexes for the treatment of tumors in mammals, are disclosed. The method of making the polymethylene derivatives, is also disclosed.
    Type: Grant
    Filed: October 14, 1998
    Date of Patent: May 9, 2000
    Assignees: Hoffmann-La Roche Inc., Virginia Commonwealth University
    Inventors: Nicholas P. Farrell, Erneston Menta, Roberto Di Domenico, Silvano Spinelli
  • Bis-platinum complexes with polyamine ligands as antitumor agents
    Patent number: 6022892
    Abstract: Bis-platinum(II) complexes with polyamine ligands, including spermidine and spermine, are disclosed. The method of making the bis-platinum(II) complexes, using a DMF complex, and the use of the bis-platinum complexes for the treatment of tumors in mammals are also disclosed. The method of making the polyamine ligands and the use of a new polyamine compound as an intermediate in the synthesis of polyamine ligands are also disclosed.
    Type: Grant
    Filed: February 22, 1998
    Date of Patent: February 8, 2000
    Assignees: Hoffman-La Roche Inc., Virginia Commonwealth University
    Inventors: Nicholas P. Farrell, Ernesto Menta, Roberto Di Domenico, Silvano Spinelli
  • Water soluble transplatinum complexes with anti-cancer activity and method of using same
    Patent number: 6001872
    Abstract: The present invention relates to the treatment of tumors with a novel water soluble trans-platinum coordination compound having the general structural formula [PtBX.sub.m (NR*.sub.3)] where B is a planar, heterocyclic ring containing at least one nitrogen atom, and a pendant chelating group; and X is an anionic ligand; and R* is hydrogen or a lower alkyl.
    Type: Grant
    Filed: March 5, 1999
    Date of Patent: December 14, 1999
    Assignee: Virginia Commonwealth University
    Inventors: Nicholas P. Farrell, Ulrich Bierbach
  • Platinum amine sulfoxide complexes
    Patent number: 5028726
    Abstract: Platinum amine sulfoxide complexes of the formula [PtCl(diam)(R.sub.2 SO)].sup.+ X.sup.- wherein diam represents a bidentate amine, R is C.sub.3 -C.sub.7 alkyl or cycloalkyl and X.sup.- is an anion, exhibit favorable anti-tumor activity in vivo against tumors susceptible to therapy with platinum.
    Type: Grant
    Filed: February 7, 1990
    Date of Patent: July 2, 1991
    Assignee: The University of Vermont and State Agricultural College
    Inventor: Nicholas P. Farrell
  • Platinum complexes with one radiosensitizing ligand
    Patent number: 5026694
    Abstract: Methods to inhibit tumor growth and to radiosensitize hypoxic cells and pharmaceutical compositions therefor are disclosed. These methods and compositions use compounds of the formulaPtX.sub.n (NR.sub.2 H) (L) (1)wherein n is 1 or 2, andwherein when n is 2, X is a monovalent biologically acceptable anion, and when n is 1, X is a divalent biologically acceptable anion;each R is independently H or alkyl, or both Rs together are a piperidino or morpholino residue; andL is a radiosensitizing ligand selected from a mononitro-substituted imidazole, a mononitro-substituted pyrazole, a mononitro-substituted thiazole and a mononitro-substituted isothiazole.
    Type: Grant
    Filed: June 30, 1989
    Date of Patent: June 25, 1991
    Assignee: The British Columbia Cancer Foundation
    Inventors: Kirsten A. Skov, Nicholas P. Farrell, David J. Chaplin
  • Platinum complexes with one radiosensitizing ligand
    Patent number: 4921963
    Abstract: Complexes of platinum II containing a single radiosensitizer ligand and an amino or ammine substituent shows superior binding to DNA and are useful in chemotherapy and sensitization of hypoxic tumors to radiation. The chemotherapeutic value of these compounds is enhanced by administration of vasoactive agents.
    Type: Grant
    Filed: April 13, 1987
    Date of Patent: May 1, 1990
    Assignee: British Columbia Cancer Foundation
    Inventors: Kirsten A. Skov, Nicholas P. Farrell, David J. Chaplin