Patents by Inventor Nicholas PARRY

Nicholas PARRY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isoindolinone inhibitors of the MDM2-P53 interaction and process for making them
    Patent number: 12077526
    Abstract: The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.
    Type: Grant
    Filed: January 25, 2023
    Date of Patent: September 3, 2024
    Assignees: ASTEX THERAPEUTICS LIMITED, CANCER RESEARCH TECHNOLOGY LIMITED
    Inventors: Steven Howard, Benjamin David Cons, Jeffrey David St. Denis, Rhian Sara Holvey, Guillaume François Parra, Kim Louise Hirst, Isabelle Anne Lemasson, David John Nash, James Daniel Osborne, Jonas Calleja Priede, Nicholas Paul Richards, Aaron Michael Dumas, Brian Christopher Bishop, David Parry-Jones, Meenakshi Sundaram Shanmugham, Darren James Dixon, Matthew James Gaunt
  • Walking stick
    Patent number: 8439057
    Abstract: A walking stick (10) having a shaft (12) having a first portion (34) and a second portion (36) received within the first portion (34) such that the second portion (36) can slide relative to the first portion (34). A first transverse handle (18) is provided at an upper end of the shaft (12) and a second handle (20) is provided pivotable between a retracted position in which the second handle (20) is generally parallel to the shaft (12) and an extended position in which the second handle (20) extends transversely to the shaft (12). A spring member (48) is provided for biasing the second portion (36) of the shaft (12) to slide outwardly from the first portion (34) and a locking mechanism is provided having a trigger (38) adjacent the first handle (18).
    Type: Grant
    Filed: February 21, 2012
    Date of Patent: May 14, 2013
    Inventors: Nicholas Parry, Edward Joseph Khoury
  • WALKING STICK
    Publication number: 20120145206
    Abstract: A walking stick (10) comprising a shaft (12) having a first portion (34) and a second portion (36) received within the first portion (34) such that the second portion (36) can slide relative to the first portion (34). A first transverse handle (18) is provided at an upper end of the shaft (12) and a second handle (20) is provided pivotable between a retracted position and an extended position. A locking mechanism having a trigger (38) secures the first portion (34) of the shaft (12) relative to the second portion (36) of the shaft (12) and actuation of the trigger (38) releases the locking mechanism such that the second portion (36) of the shaft (12) can slide outwardly from the first portion (34) of the shaft (12) under the force of a spring member (48).
    Type: Application
    Filed: February 21, 2012
    Publication date: June 14, 2012
    Inventors: Nicholas PARRY, Edward Joseph KHOURY