Abstract: A method includes providing a cartridge and the cartridge includes a slot for receiving a microfluidic chip having a set of first channels. The cartridge also includes a set of second channels and each channel of the set of second channels is coupleable to a different channel of the set of first channels during use with the microfluidic chip. The cartridge also includes an indent configured for engagement and alignment of the cartridge during use. The method also includes inserting the cartridge into a device, such that the cartridge engages a first biasing member of the device configured for alignment of the cartridge in a first direction. The first biasing member is configured to bias movement of the cartridge into locking position with a notch of the device.

Abstract: A robotic vehicle, such as an autonomous mobile robot (AMR), is provided, comprising a chassis, a navigation system, and a load engagement portion, a plurality of sensors, including an object detection sensor, and a load interaction system. The AMR is configured to perform a load drop and a load pickup within a zone without using predetermined load pick up and drop off locations within the zone. The AMR can determine where to place a load within the zone based on proximity to another object or physical structure within the zone. A location of the zone on the AMR's route can be trained, but pickup and drop locations within the zone can be untrained and undefined in advance.

Abstract: This invention relates to compounds of Formula (I): and enantiomers thereof, and to pharmaceutically acceptable salts of Formula (I) and said enantiomers, wherein L1, L2, R1, R2, R3 and n are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof.

Abstract: Methods and apparatus consistent with the invention provide the ability to organize, index, search, and present time series data based on searches. Time series data are sequences of time stamped records occurring in one or more usually continuous streams, representing some type of activity. In one embodiment, time series data is stored as discrete events time stamps. A search is received and relevant event information is retrieved based in whole or in part on the time stamp, a keyword indexing mechanism, or statistical indices calculated at the time of the search.

Abstract: Systems and methods for rendering spatial audio in accordance with embodiments of the invention are illustrated. One embodiment includes a spatial audio system, including a primary network connected speaker, including a plurality of sets of drivers, where each set of drivers is oriented in a different direction, a processor system, memory containing an audio player application, wherein the audio player application configures the processor system to obtain an audio source stream from an audio source via the network interface, spatially encode the audio source, decode the spatially encoded audio source to obtain driver inputs for the individual drivers in the plurality of sets of drivers, where the driver inputs cause the drivers to generate directional audio.

Abstract: An apparatus that facilitates search and rescue, for example, in open water. The apparatus comprises a substrate with a particular geometry and a perimeter. The apparatus further comprises a cover positioned atop the substrate with the cover also having a particular geometry and perimeter, which correspond to the geometry and perimeter of the substrate. An air-tight seal seals the substrate perimeter to the cover perimeter and creates a sealed internal region. A liquid-releasable vessel holding an illuminable dye located in the sealed internal region, along with an activator that is also located in the sealed internal region. When the liquid-releasable vessel releases the illuminable dye, the illuminable dye reacts with the activator, thereby resulting in illumination of the illuminable dye. The liquid-releasable vessel comprises an opening with a release mechanism (e.g., clamp, etc.).

Abstract: An automated damping system including a damping device arranged and disposed to provide variable resistance to a load. The variable resistance provides resistance values corresponding to a displacement position of the damping device. The system includes a damping profile generator that calculates a damping profile and a sensor is arranged and disposed to measure one or more damping affecting properties. The sensor provides the one or more damping affecting properties to the damping profile generator. The damping profile provides the variable resistance based upon the one or more damping affecting properties of the load.

Abstract: Example methods, apparatus, and articles of manufacture to estimate waiting times of prescriptions are disclosed herein. An example computer-implemented method, executed by a processor, to estimate a waiting time of a prescription for a medication includes training a machine learning model using, for each of a plurality of previously filled prescriptions, a set of characteristics of the previously filled prescription, and a fill time for the previously filled prescription, receiving a prescription for a medication for a patient, receiving a request for an estimated waiting time for filling the prescription medication for the patient, identifying a set of characteristics of the prescription medication for the patient, applying the set of characteristics of the prescription medication to the machine learning model to determine the estimated waiting time for filling the prescription medication for the patient, and providing an indication of the estimated waiting time for display on a client device.

Abstract: An analysis container includes an outer tube and a plurality of inner tubes. The outer tube defines a buffer volume that is configured to receive a buffer material. The plurality of inner tubes is disposed within the buffer volume. Each inner tube has an inner diameter equal to or less than 6 mm and is configured to receive a biopharmaceutical composition therein. The outer tube is configured such that the buffer material and the biopharmaceutical composition are axially frozen.

Abstract: Example methods, apparatus, and articles of manufacture to estimate waiting times of prescriptions are disclosed herein. An example computer-implemented method, executed by a processor, to estimate a waiting time of a prescription for a medication includes training a machine learning model using, for each of a plurality of previously filled prescriptions, a set of characteristics of the previously filled prescription, and a fill time for the previously filled prescription, receiving a prescription for a medication for a patient, receiving a request for an estimated waiting time for filling the prescription medication for the patient, identifying a set of characteristics of the prescription medication for the patient, applying the set of characteristics of the prescription medication to the machine learning model to determine the estimated waiting time for filling the prescription medication for the patient, and providing an indication of the estimated waiting time for display on a client device.

Abstract: A hanging device and methods of making the hanging device are shown and described herein. The hanging device may be a hook or a hanging device. The hanging device comprises: a) a first outer liner; b) at least one inner layer; and c) a second outer liner. For the hanging device, the first outer liner is at least partially disposed on the at least one inner layer and the second outer liner is at least partially disposed on the at least one inner layer, and the first outer liner, the at least one inner layer, and the second outer liner are laminated together. The hanging device may be comprised of a biobased material and/or a recycled material. The hanging device may be biodegradable.

Abstract: Methods for somatic variant calling from an unmatched biological samples is provided. The method can include obtaining nucleic acid sequence data corresponding to a biological sample of a subject. The method can also include aligning the nucleic acid sequence data to a reference genome. The method can also include identifying, based on the aligned nucleic acid sequence data, a set of candidate variants in said nucleic acid sequence data. The set of candidate variants may include one or more somatic variants and one or more germline variants. The method can also include, without using a nucleic acid sequencing data from a matching biological sample of the subject, processing the set of candidate variants using a trained machine-learning model to identify the somatic variants. The method can also include outputting a report that identifies the somatic variants.

Abstract: The disclosure provides methods for estimating tumor purity from tumor samples without use of matched-normal controls. A set of genomic regions are identified based on a nucleic acid sequence data that is aligned to a reference genome. Each genomic region of the set of genomic regions includes one or more nucleotide-sequence variants relative to a corresponding genomic region of the reference genome. A B-allele frequency distribution for the biological sample is determined based on a B-allele frequency determined for each genomic region of the set of genomic regions. The B-allele frequency distribution is processed using a trained machine-learning model to estimate a metric identifying tumor purity in the biological sample.

Abstract: A weight lifting bar, such as a pull-up bar is provided. The pull-up bar may be wall-mounted or utilized with a power rack. The bar includes a cylindrical bar, which is typically made of steel. The bar further includes a sand-blasted finish applied to the cylindrical bar. The sand-blasted finish creates a layer over at least a portion of the cylindrical bar.

Abstract: The invention is directed to a sensor apparatus for determining when a water outlet needs flushing, comprising a water flow monitoring sensor adapted to be in contact with a source of water flowing through a conduit; a microprocessor in electronic communication with the water flow monitoring sensor, the microprocessor configured to calculate whether the water stagnation time exceeds a predetermined threshold; and indicia for signaling when the water needs flushing by a user, the indicia n electronic communication with the microprocessor. The water flow monitoring sensor may include an accelerometer for detecting water flow vibrations typical of water flow in water conduits. A microprocessor calculates and tracks the total flush time since the prior flush of a drinking water source, thereby monitoring its safety for users of the water source.

Abstract: In an exemplary embodiment, an apparatus for a sustainable clip is shown and described. The sustainable clip may be formed from compressed board. The sustainable clip may be formed to provide a functionality that is the same or improved over known clips, while also decreasing manufacture cost and reducing waste associated with those clips.

Abstract: The present invention relates to compounds of Formula (I), or an agronomically acceptable salt of said compounds wherein A1a, A1b, R1, R2, R3 and R4 and R5 are as defined herein. The invention further relates to herbicidal compositions which comprise a compound of Formula (I), and to their use for controlling weeds, in particular in crops of useful plants.

Abstract: The present invention relates to compounds of Formula (I), or an agronomically acceptable salt of said compounds wherein A1a, A1b, R1, R2, R3 and R4 and R5 are as defined herein. The invention further relates to herbicidal compositions which comprise a compound of Formula (I), and to their use for controlling weeds, in particular in crops of useful plants.