Abstract: A targeted nanosphere and submicron controlled delivery system for topical and transdermal use is disclosed. The controlled delivery system can be used as a targeted drug delivery system. The controlled delivery system is a composition of active ingredients encapsulated in sub-micron spheres, optionally with an additional protective shell. The sphere includes a solid core and a semi-liquid shell. The size of the delivery system can be selected to supply the active ingredients in a targeted manner to the skin to treat skin conditions or through follicular penetration in order to treat for example, follicular diseases and stimulate or reduce hair growth.