Patents by Inventor Nicholas Popescu

Nicholas Popescu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DLC-1 gene deleted in cancers
    Patent number: 7534565
    Abstract: A cDNA molecule corresponding to a newly discovered human gene is disclosed. The new gene, which is frequently deleted in liver cancer cells and cell lines, is called the DLC-1 gene. Because the gene is frequently deleted in liver cancer cells, but present in normal cells, it is thought to act as a tumor suppressor. This gene is also frequently deleted in breast and colon cancers, and its expression is decreased or undetectable in many prostate and colon cancers. Also disclosed is the amino acid sequence of the protein encoded by the DLC-1 gene. Methods of using these biological materials in the diagnosis and treatment of hepatocellular cancer, breast cancer, colon cancer, prostate cancer, and adenocarcinomas are presented.
    Type: Grant
    Filed: November 22, 2004
    Date of Patent: May 19, 2009
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Bao-Zhu Yuan, Snorri S. Thorgeirsson, Nicholas Popescu
  • DLC-1 gene deleted in cancers
    Publication number: 20050227255
    Abstract: A cDNA molecule corresponding to a newly discovered human gene is disclosed. The new gene, which is frequently deleted in liver cancer cells and cell lines, is called the DLC-1 gene. Because the gene is frequently deleted in liver cancer cells, but present in normal cells, it is thought to act as a tumor suppressor. This gene is also frequently deleted in breast and colon cancers, and its expression is decreased or undetectable in many prostate and colon cancers. Also disclosed is the amino acid sequence of the protein encoded by the DLC-1 gene. Methods of using these biological materials in the diagnosis and treatment of hepatocellular cancer, breast cancer, colon cancer, prostate cancer, and adenocarcinomas are presented.
    Type: Application
    Filed: November 22, 2004
    Publication date: October 13, 2005
    Inventors: Bao-Zhu Yuan, Snorri Thorgeirsson, Nicholas Popescu
  • DLC-1 gene deleted in cancers
    Patent number: 6897018
    Abstract: A cDNA molecule corresponding to a newly discovered human gene is disclosed. The new gene, which is frequently deleted in liver cancer cells and cell lines, is called the DLC-1 gene. Because the gene is frequently deleted in liver cancer cells, but present in normal cells, it is thought to act as a tumor suppressor. This gene is also frequently deleted in breast and colon cancers, and its expression is decreased or undetectable in many prostate and colon cancers. Also disclosed is the amino acid sequence of the protein encoded by the DLC-1 gene. Methods of using these biological materials in the diagnosis and treatment of hepatocellular cancer, breast cancer, colon cancer, prostate cancer, and adenocarcinomas are presented.
    Type: Grant
    Filed: August 23, 2000
    Date of Patent: May 24, 2005
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Bao-Zhu Yuan, Snorri S. Thorgeirsson, Nicholas Popescu
  • DLC-1 gene deleted in cancers
    Publication number: 20050106616
    Abstract: A cDNA molecule corresponding to a newly discovered human gene is disclosed. The new gene, which is frequently deleted in liver cancer cells and cell lines, is called the DLC-1 gene. Because the gene is frequently deleted in liver cancer cells, but present in normal cells, it is thought to act as a tumor suppressor. This gene is also frequently deleted in breast and colon cancers, and its expression is decreased or undetectable in many prostate and colon cancers. Also disclosed is the amino acid sequence of the protein encoded by the DLC-1 gene. Methods of using these biological materials in the diagnosis and treatment of hepatocellular cancer, breast cancer, colon cancer, prostate cancer, and adenocarcinomas are presented.
    Type: Application
    Filed: November 24, 2004
    Publication date: May 19, 2005
    Inventors: Bao-Zhu Yuan, Snorri Thorgeirsson, Nicholas Popescu