Patents by Inventor Nicholas R. Natale

Nicholas R. Natale has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Radiolabeled inhibitors of the amino acid transporters ASCT1 and ASCT2
    Patent number: 9512074
    Abstract: The present invention relates to a compound of Formula (I) or (II) or a salt thereof, wherein R is described herein. The compounds are novel hydroxy-proline analog inhibitors of the ASCT1 and ASCT2 neutral amino acid transporters.
    Type: Grant
    Filed: October 15, 2014
    Date of Patent: December 6, 2016
    Assignee: THE UNIVERSITY OF MONTANA
    Inventors: Christopher Sean Esslinger, Michael P. Kavanaugh, Brent Lyda, Nicholas R. Natale
  • Novel Inhibitors of System Xc-
    Publication number: 20150368213
    Abstract: The present invention is directed to novel inhibitors of system Xc?, also known as the cystine/glutamate antiporter. The present invention is further directed to methods of treating and detecting cancer that overexpresses system Xc? which includes but is not limited to gliomas (including glioblastoma), triple negative breast cancer, and bladder cancer. The present invention is further directed to methods of treating seizures including epileptic seizures.
    Type: Application
    Filed: June 19, 2015
    Publication date: December 24, 2015
    Inventors: Nicholas R. Natale, Richard J. Bridges, Sarjubhai A. Patel, Nathan S. Duncan, Matthew J. Weaver, Mariusz P. Gajewski
  • BLOOD SUGAR CONCENTRATION (BSC) TESTING AND MONITORING SYSTEM AND METHOD
    Publication number: 20150335272
    Abstract: Disclosed and depicted is a system and method for reliably testing, monitoring and predicting blood sugar concentration (e.g., glucose) for a user.
    Type: Application
    Filed: May 20, 2015
    Publication date: November 26, 2015
    Inventors: Nicholas R. Natale, Nicholas P. Nicoletti
  • Inhibitors of the amino acid transporters ASCT1 and ASCT2
    Patent number: 8895607
    Abstract: The present invention relates to a compound of Formula (I) or (II) or a salt thereof, wherein R is described herein. The compounds are novel hydroxy-proline analog inhibitors of the ASCT1 and ASCT2 neutral amino acid transporters.
    Type: Grant
    Filed: July 16, 2012
    Date of Patent: November 25, 2014
    Assignee: The University of Montana
    Inventors: Michael P. Kavanaugh, Brent Lyda, Nicholas R. Natale, Stephanie Lynn Martinelli
  • Novel Inhibitors of the Amino Acid Transporters ASCT1 and ASCT2
    Publication number: 20130065935
    Abstract: The invention features compounds and methods relating to novel hydroxy-proline analog inhibitors of the ASCT1 and ASCT2 neutral amino acid transporters. These analogs are potent and selective inhibitors of ASCT2 and ASCT1-mediated amino acid transport as evidenced by significantly reduced glutamine or alanine transport-associated currents or radiolabeled substrate (amino acid) uptake in Xenopus oocytes expressing ASCT2 or ASCT1. Selectivity has been established in the same manner whereby reduced substrate associated current or substrate uptake is unobserved in Xenopus oocytes expressing ATA2, SN1, or EAAT(s) (excitatory amino acid transporter). The compounds and methods of the invention can be used in research or clinical applications (e.g., for the treatment of cancer, microbial infection, or ischemia-related central nervous system injury).
    Type: Application
    Filed: July 16, 2012
    Publication date: March 14, 2013
    Inventors: Michael P. Kavanaugh, Brent Lyda, Nicholas R. Natale, Stephanie Lynn Martinelli
  • Hydroxamic acid crown ethers
    Patent number: 5274129
    Abstract: Novel derivatives of hydroxamic acid chelating agents for the chelation of f-block elements, yttrium and scandium and methods for the extraction of such elements.
    Type: Grant
    Filed: June 12, 1991
    Date of Patent: December 28, 1993
    Assignee: Idaho Research Foundation, Inc.
    Inventors: Nicholas R. Natale, Chien M. Wai, Sadik Elshani