Abstract: Compounds of Formula (I): wherein R1, R3, R11, R12, X, Y1, Y2, Y3, Y4 and are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring anti-apoptotic inhibitors.

Abstract: Devices and methods for measuring a concentration of a target analyte in a biological fluid in vivo are provided herein. In some examples, a device includes an indwelling sensor and sensor electronics. The sensor may include a substrate; a first electrode disposed on the substrate; an ionophore disposed on the substrate to selectively transport the target ion to or within the first electrode; and a second electrode disposed on the substrate. The sensor electronics is configured to generate a signal corresponding to an electromotive force which is at least partially based on a potential difference that is generated between the first electrode and the second electrode responsive to the ionophore transporting the target ion to the first electrode.

Abstract: The present invention provides heteroaryl ketone fused azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators, including their use for treating amyotrophic lateral sclerosis (ALS).

Abstract: The present invention provides heteroaryl ketone fused azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators, including their use for treating amyotrophic lateral sclerosis (ALS).

Abstract: A safety valve is configured for use at temperatures at or above 760° C. (1400° F.). The safety valve includes a closure assembly that can create a self-energizing, metal-to-metal seal. In one implementation, this closure assembly includes a disc with an arcuate finger that circumscribes an axis of fluid flow through a seat. The arcuate finger may extend inwardly toward this axis and downwardly toward the seat. This geometry permits the finger to flex in response to pressure of fluid that impinges on the downstream side of the disc, such flexure causing a first sealing surface on the disc to more forcefully contact a second sealing surface on a seat.

Abstract: The present invention provides heteroaryl ketone fused azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators.

Abstract: An inflation-based antifouling system and method that include an inflatable film configured to be disposed on a target clean surface; and an inflation device that inflates the inflatable film such that bio-fouling is removed from the target clean surface.

Abstract: A safety valve is configured for use at temperatures at or above 760° C. (1400° F.). The safety valve includes a closure assembly that can create a self-energizing, metal-to-metal seal. In one implementation, this closure assembly includes a disc with an arcuate finger that circumscribes an axis of fluid flow through a seat. The arcuate finger may extend inwardly toward this axis and downwardly toward the seat. This geometry permits the finger to flex in response to pressure of fluid that impinges on the downstream side of the disc, such flexure causing a first sealing surface on the disc to more forcefully contact a second sealing surface on a seat.

Abstract: An internal ultraviolet-C light emitting diode antifouling system and method that include a waterproof, light transmissible potted enclosure; an object disposed within the waterproof, light transmissible potted enclosure; and at least one ultraviolet-C light emitting diode disposed within the waterproof, light transmissible enclosure, wherein the at least one ultraviolet-C light emitting diode is configured to emit light on the object, wherein the light is configured to prevent biofouling on the object.

Abstract: The present invention provides heteroaryl ketone fused azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators, including their use for treating amyotrophic lateral sclerosis (ALS).

Abstract: An inflation-based antifouling system and method that include an inflatable film configured to be disposed on a target clean surface; and an inflation device that inflates the inflatable film such that bio-fouling is removed from the target clean surface.

Abstract: A system comprises a tank header configured to couple to a reductant tank and a heating mechanism positioned proximate to the tank header. The heating mechanism is configured to heat at least a portion of the tank header. The system may further comprise a conduit configured to pass reductant from the reductant tank and a junction configured to receive reductant from the reductant tank.

Abstract: An internal ultraviolet-C light emitting diode antifouling system and method that include a waterproof, light transmissible potted enclosure; an object disposed within the waterproof, light transmissible potted enclosure; and at least one ultraviolet-C light emitting diode disposed within the waterproof, light transmissible enclosure, wherein the at least one ultraviolet-C light emitting diode is configured to emit light on the object, wherein the light is configured to prevent biofouling on the object.

Abstract: The present invention provides heteroaryl ketone fused azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators.

Abstract: The present invention provides heteroaryl ketone fused azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators.

Abstract: The invention includes a method of promoting atomic layer etching (ALE) of a surface. In certain embodiments, the method comprises sequential reactions with a metal precursor and a halogen-containing gas. In other embodiments, the etching rate is increased by removing residual species bound to and/or adsorbed onto the surface.

Abstract: Systems, apparatuses, and methods are provided herein for store management. A system for store management comprises: a storage system in a backroom area, a conveyor system, a return sensor system, and a control circuit. The control circuit being configured to: receive an interact request from a customer via a user interface device in a showroom area, cause the conveyor system to retrieve one or more items from the storage system and transport the one or more items to the item interaction area based on the interact request, receive a return request, cause the return sensor system to collect data from the at least one item, determine whether to accept the return request based on the data collected by the return sensor system, and cause the conveyor system to retrieve the at least one item from the customer and make the at least one item available for another customer.

Abstract: An unmanned battery optimization vehicle includes a transceiver, a battery optimization apparatus, and a control circuit. The transceiver is configured to transmit and receive signals. The battery optimization apparatus is configured to interact with a battery disposed at an unmanned autonomous vehicle. The control circuit is coupled to the transceiver and the battery optimization apparatus. The control circuit is configured to cause the unmanned battery optimization vehicle to independently navigate and travel to a present location of the autonomous vehicle based at least in part upon the signals received at the transceiver. When the unmanned battery optimization vehicle reaches the present location of the unmanned autonomous vehicle, the control circuit is further configured to direct the battery optimization apparatus to engage in an interaction with the battery at the unmanned autonomous vehicle. The interaction is effective to optimize battery operation at the unmanned autonomous vehicle.

Abstract: A system comprises a tank header configured to couple to a reductant tank and a heating mechanism positioned proximate to the tank header. The heating mechanism is configured to heat at least a portion of the tank header. The system may further comprise a conduit configured to pass reductant from the reductant tank and a junction configured to receive reductant from the reductant tank.

Abstract: The present invention provides heteroaryl ketone fused azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators.