Abstract: The present invention relates to a photochemical process for the manufacturing of a C-terminal ?-amide, which are a class of compounds that represent up to half of all biologically relevant peptide hormones. The invention provides mild, broad in scope, economically efficient process, which is suitable for large scale manufacturing.

Abstract: The invention relates to apparel and methods for supporting a movement of an athlete during an asymmetrical athletic motion. An example asymmetric garment for at least a portion of a body of a wearer includes a first material portion and a second material portion, with the first material portion and second material portion being arranged asymmetrically with respect to a central vertical plain of the garment, and with the second material being adapted to provide a lesser resistance to at least one of stretching or twisting than the first material to reduce resistance to a movement of the wearer during an asymmetrical athletic motion.

Abstract: A perforating apparatus and method includes a longitudinal cylinder axis about which a cylinder rotates. At least one shaped anvil bead is disposed on the cylinder. The cylinder including an anvil block and an anvil bead form a cavity. The cavity may be used to control the debris produced during the perforating process. A blade is disposed on a support to cooperate in contacting relationship with the anvil bead. A web is perforated as the web passes between the rotating cylinder and the support and the blade operatively engages with the anvil bead. The debris may be controlled by being drawn into the cavity prior to the point where the blade engages the anvil and, subsequently, being expelled after the point where the blade engages the anvil bead.

Abstract: A perforating apparatus and method includes a longitudinal cylinder axis about which a cylinder rotates. At least one shaped anvil bead is disposed on the cylinder. The cylinder including an anvil block and an anvil bead form a cavity. The cavity may be used to control the debris produced during the perforating process. A blade is disposed on a support to cooperate in contacting relationship with the anvil bead. A web is perforated as the web passes between the rotating cylinder and the support and the blade operatively engages with the anvil bead. The debris may be controlled by being drawn into the cavity prior to the point where the blade engages the anvil and, subsequently, being expelled after the point where the blade engages the anvil bead.

Abstract: The present invention relates to relates to a polymer formulation for three-dimensionally (3D) printing an article by stereolithography, the formulation comprising a functionalized polymer. The invention further relates to lithographic methods to form 3D objects that incorporate the aforementioned polymer formulation.

Abstract: The present invention relates to novel peptides that are derivatives of glucose-dependent insulinotropic polypeptide (GIP) analogues having improved physical stability in solution and a protracted profile of action. More particular the invention relates to such peptides that are agonists at the GIP receptor and to their use in weight management or for treatment of diseases such as obesity, diabetes or non-alcoholic steatohepatitis (NASH).

Abstract: The invention relates to apparel and methods for supporting a movement of an athlete during an asymmetrical athletic motion. An example asymmetric garment for at least a portion of a body of a wearer includes a first material portion and a second material portion, with the first material portion and second material portion being arranged asymmetrically with respect to a central vertical plain of the garment, and with the second material being adapted to provide a lesser resistance to at least one of stretching or twisting than the first material to reduce resistance to a movement of the wearer during an asymmetrical athletic motion.

Abstract: A method that prints a functional element on a surface of a receiving area of a timepiece component of a timepiece contributing to regulating the rate of this timepiece includes preparing a solution containing a material constituting the functional element and depositing the prepared solution onto the surface of the receiving area. Specific properties of the solution are defined as a function of preparation criteria and include at least one structural modification feature of the timepiece component, at least one construction feature of the functional element on the receiving area, at least one structural feature of the material to be applied to the receiving area, and at least one feature of the receiving area of the component.

Abstract: A perforating apparatus and method includes a longitudinal cylinder axis about which a cylinder rotates. At least one shaped anvil bead is disposed on the cylinder. The cylinder including an anvil block and an anvil bead form a cavity. The cavity may be used to control the debris produced during the perforating process. A blade is disposed on a support to cooperate in contacting relationship with the anvil bead. A web is perforated as the web passes between the rotating cylinder and the support and the blade operatively engages with the anvil bead. The debris may be controlled by being drawn into the cavity prior to the point where the blade engages the anvil and, subsequently, being expelled after the point where the blade engages the anvil bead.

Abstract: A perforating apparatus and method includes a longitudinal cylinder axis about which a cylinder rotates. At least one shaped anvil bead is disposed on the cylinder. The cylinder including an anvil block and an anvil bead form a cavity. The cavity may be used to control the debris produced during the perforating process. A blade is disposed on a support to cooperate in contacting relationship with the anvil bead. A web is perforated as the web passes between the rotating cylinder and the support and the blade operatively engages with the anvil bead. The debris may be controlled by being drawn into the cavity prior to the point where the blade engages the anvil and, subsequently, being expelled after the point where the blade engages the anvil bead.

Abstract: A perforating apparatus and method includes a longitudinal cylinder axis about which a cylinder rotates. At least one shaped anvil bead is disposed on the cylinder. The cylinder including an anvil block and an anvil bead form a cavity. The cavity may be used to control the debris produced during the perforating process. A blade is disposed on a support to cooperate in contacting relationship with the anvil bead. A web is perforated as the web passes between the rotating cylinder and the support and the blade operatively engages with the anvil bead. The debris may be controlled by being drawn into the cavity prior to the point where the blade engages the anvil and, subsequently, being expelled after the point where the blade engages the anvil bead.

Abstract: A perforating apparatus and method includes a longitudinal cylinder axis about which a cylinder rotates. At least one shaped anvil bead is disposed on the cylinder. The cylinder including an anvil block and an anvil bead form a cavity. The cavity may be used to control the debris produced during the perforating process. A blade is disposed on a support to cooperate in contacting relationship with the anvil bead. A web is perforated as the web passes between the rotating cylinder and the support and the blade operatively engages with the anvil bead. The debris may be controlled by being drawn into the cavity prior to the point where the blade engages the anvil and, subsequently, being expelled after the point where the blade engages the anvil bead.

Abstract: Ucn2 derivatives comprising a peptide and a substituent with high potency, high physical and high chemical stability, suitable for administration to humans, and their medical use in treatment and/or prevention of obesity and/or diabetes.

Abstract: The present invention relates to novel peptides that are derivatives of glucose-dependent insulinotropic polypeptide (GIP) analogues having improved physical stability in solution and a protracted profile of action. More particular the invention relates to such peptides that are agonists at the GIP receptor and to their use in weight management or for treatment of diseases such as obesity, diabetes or non-alcoholic steatohepatitis (NASH).

Abstract: The present invention relates to novel peptides that are derivatives of glucose-dependent insulinotropic polypeptide (GIP) analogues having improved physical stability in solution and a protracted profile of action. More particular the invention relates to such peptides that are agonists at the GIP receptor and to their use in weight management or for treatment of diseases such as obesity, diabetes or non-alcoholic steatohepatitis (NASH).

Abstract: The present invention relates to relates to a polymer formulation for three-dimensionally (3D) printing an article by stereolithography, the formulation comprising a functionalized polymer. The invention further relates to lithographic methods to form 3D objects that incorporate the aforementioned polymer formulation.

Abstract: Compounds and methods are provided for inhibiting a CREB-CBP protein-protein interaction in a sample. In some cases, the method includes modulating transcription of CREB in a cell that overexpresses CREB. Also provided are methods of inhibiting the proliferation of a cancer cell. The subject CREB transcription inhibitor compounds include a substituted salicylamide or a prodrug thereof. Methods of alleviating symptoms associated with cancer (e.g., Acute Myeloid Leukemia (AML) or Acute Lymphomblastic Leukemia (ALL)) in a subject in need thereof are also provided. Pharmaceutical compositions including the subject compounds find use in treating cancer. The subject compounds may be formulated or provided to a subject in combination with a second agent, e.g. an anticancer agent.

Abstract: The present invention relates to novel peptides that are derivatives of glucose-dependent insulinotropic polypeptide (GIP) analogues having improved physical stability in solution and a protracted profile of action. More particularly the invention relates to such peptides that are agonists at the GIP receptor and to their use in weight management or for treatment of diseases such as obesity, diabetes or non-alcoholic steatohepatitis (NASH). The peptides comprise a lysine residue at a position corresponding to position 24 of hGIP(1-31), and comprise a negatively charged modifying group attached to the epsilon amino group of the lysine residue.

Abstract: The present invention relates to novel peptides that are derivatives of glucose-dependent insulinotropic polypeptide (GIP) analogues having improved physical stability in solution and a protracted profile of action. More particular the invention relates to such peptides that are agonists at the GIP receptor and to their use in weight management or for treatment of diseases such as obesity, diabetes or non-alcoholic steatohepatitis (NASH).