Abstract: The invention relates to the wheat cultivar designated 01092989. Provided by the invention are the seeds, plants and derivatives of the wheat cultivar 01092989. Also provided by the invention are tissue cultures of the wheat cultivar 01092989 and the plants regenerated therefrom. Still further provided by the invention are methods for producing wheat plants by crossing the wheat cultivar 01092989 with itself or another wheat cultivar and plants produced by such methods.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

Abstract: Disclosed herein are various embodiments relating generally to a system for lifting water from an aquifer formation by drilling a u-shaped well through the aquifer formation, which comprises a water well screen within the aquifer formation with an inner production string with a series of check valves within the aquifer formation that allow water from the aquifer to flow from the water well screen and into the production string while preventing the water from leaving the production string, and then uses air pressure to force the water through a larger check valve in the production string, so that it may be collected in a surface tank. When not extracting water from the aquifer formation, the system allows treated water to be pumped into the outer casing and back into the aquifer, thereby recharging the aquifer formation with water.

Abstract: A credit card cleaning apparatus for quickly and conveniently sanitizing a credit card includes a housing having a housing top side, a housing bottom side, a housing front side, a housing back side, a housing left side, and a housing right side. The housing front side is spaced apart from the housing back side in parallel opposition defining a housing interior. The housing top side has a card slot extending through to the housing interior. The housing receives a credit card through the card slot. A brush is coupled to the housing. The brush is coupled to the housing back side within the housing interior and is saturated with a sanitizing solution. The brush applies the sanitizing solution to the credit card when it is inserted through the card slot.

Abstract: A system includes: an engine; and an aftertreatment system for treating exhaust gas produced by the engine, the aftertreatment system including: an exhaust conduit configured to receive the exhaust gas and hydrocarbons from the engine; a preheating oxidation catalyst; a primary oxidation catalyst disposed downstream of the preheating oxidation catalyst; a selective catalytic reduction system disposed in the exhaust conduit downstream of the primary oxidation catalyst. The aftertreatment system includes: a controller configured to: determine a temperature of the exhaust gas at an inlet of the selective catalytic reduction system, and in response to the temperature of the exhaust gas at the inlet of the selective catalytic reduction system being below a threshold temperature, cause the engine to provide the hydrocarbons to the exhaust conduit.

Abstract: An aftertreatment system for treating an exhaust gas comprises an exhaust conduit, a preheating oxidation catalyst, a primary oxidation catalyst disposed downstream of the preheating oxidation catalyst, and a selective catalytic reduction system disposed in the exhaust conduit downstream of the primary oxidation catalyst. A controller is configured to determine a temperature of an exhaust gas at an inlet of the selective catalytic reduction system. In response to the temperature being below a threshold temperature, the controller generates a hydrocarbon insertion signal configured to cause hydrocarbons to be inserted into or upstream of the preheating oxidation catalyst so as to increase a temperature of the exhaust gas to above the threshold temperature.

Abstract: A condiment bottle includes a container and cap assembly. The cap assembly includes a securing part releasably connected to the container, a nozzle secured to the container by the securing part, and a closure part connected to both the securing part and the nozzle. The closure part is configured to move along a longitudinal axis of the condiment bottle from a closed position where the closure part sealingly engages the nozzle to an intermediate position where the closure part is spaced from and covering the top of the nozzle. The closure part is further configured to pivotally move from the intermediate position to an open position where the closure part is located along a sidewall of the nozzle.

Abstract: A condiment bottle includes a container and cap assembly. The cap assembly includes a securing part releasably connected to the container, a nozzle secured to the container by the securing part, and a closure part connected to both the securing part and the nozzle. The closure part is configured to move along a longitudinal axis of the condiment bottle from a closed position where the closure part sealingly engages the nozzle to an intermediate position where the closure part is spaced from and covering the top of the nozzle. The closure part is further configured to pivotally move from the intermediate position to an open position where the closure part is located along a sidewall of the nozzle.

Abstract: A credit card cleaning apparatus for quickly and conveniently sanitizing a credit card includes a housing having a housing top side, a housing bottom side, a housing front side, a housing back side, a housing left side, and a housing right side. The housing front side is spaced apart from the housing back side in parallel opposition defining a housing interior. The housing top side has a card slot extending through to the housing interior. The housing receives a credit card through the card slot. A brush is coupled to the housing. The brush is coupled to the housing back side within the housing interior and is saturated with a sanitizing solution. The brush applies the sanitizing solution to the credit card when it is inserted through the card slot.

Abstract: A beverage brewing apparatus includes a body including a body side wall having an inner surface and an outer surface. A base is removably connected to the body and includes a base side wall and a top wall. The base side wall has an inner surface and an outer surface. A valve assembly is mounted to the base. The valve assembly includes a valve plate and a valve seal connected to the valve plate. The valve seal is movable from a closed position where the valve seal is in contact with the top wall and an open position. A filter assembly is mounted to the base, and includes a filter having a peripheral edge and a gasket having a flange. The gasket is secured to the peripheral edge of the filter, and assembling the body, base, and filter assembly secures the gasket flange between the body and the base.

Abstract: An aftertreatment system for treating an exhaust gas comprises an exhaust conduit, a preheating oxidation catalyst, a primary oxidation catalyst disposed downstream of the preheating oxidation catalyst, and a selective catalytic reduction system disposed in the exhaust conduit downstream of the primary oxidation catalyst. A controller is configured to determine a temperature of an exhaust gas at an inlet of the selective catalytic reduction system. In response to the temperature being below a threshold temperature, the controller generates a hydrocarbon insertion signal configured to cause hydrocarbons to be inserted into or upstream of the preheating oxidation catalyst so as to increase a temperature of the exhaust gas to above the threshold temperature.

Abstract: An extendable straw includes a relatively smaller diameter tube, a relatively larger diameter tube, and a collar. The smaller diameter tube includes a radially enlarged section adjacent one end. The larger diameter tube receives the smaller diameter tube and is more flexible than the smaller diameter tube. The radially enlarged section contacts and seals against an inner surface of the larger diameter tube. The collar is connected at a non-drinking end of the larger diameter tube, the collar being more rigid than the larger diameter tube and receiving the smaller diameter tube. The smaller diameter tube is movable in an axial direction with respect to both the collar and the larger diameter tube. At least one of the collar and the larger diameter tube cooperates with the radially enlarged section to inhibit further axial movement of the smaller diameter tube with respect to the collar beyond an extended position.

Abstract: An extendable straw includes a relatively smaller diameter tube, a relatively larger diameter tube, and a collar. The smaller diameter tube includes a radially enlarged section adjacent one end. The larger diameter tube receives the smaller diameter tube and is more flexible than the smaller diameter tube. The radially enlarged section contacts and seals against an inner surface of the larger diameter tube. The collar is connected at a non-drinking end of the larger diameter tube, the collar being more rigid than the larger diameter tube and receiving the smaller diameter tube. The smaller diameter tube is movable in an axial direction with respect to both the collar and the larger diameter tube. At least one of the collar and the larger diameter tube cooperates with the radially enlarged section to inhibit further axial movement of the smaller diameter tube with respect to the collar beyond an extended position.

Abstract: A beverage brewing apparatus includes a body including a body side wall having an inner surface and an outer surface. A base is removably connected to the body and includes a base side wall and a top wall. The base side wall has an inner surface and an outer surface. A valve assembly is mounted to the base. The valve assembly includes a valve plate and a valve seal connected to the valve plate. The valve seal is movable from a closed position where the valve seal is in contact with the top wall and an open position. A filter assembly is mounted to the base, and includes a filter having a peripheral edge and a gasket having a flange. The gasket is secured to the peripheral edge of the filter, and assembling the body, base, and filter assembly secures the gasket flange between the body and the base.

Abstract: An orienting device for receiving a bulk flow of unshelled pistachio nuts and aligning and orienting them to provide single flows of nuts having a desired, common orient, the device comprises: an orienting section (27) comprising a plurality of tracks (25), which receive a flow of nuts from an infeed section, and align and orient the nuts, each track (25) comprising an orienting part (29), which comprises a base and first and second lateral orienting guides (39) makes the nuts rotate. The tray is a vibrating tray.

Abstract: A multi-functional golf swing training apparatus includes first and second arm braces that are adapted to be removably attached to user forearms respectively. A first mechanism is provided for pivotally mating the first arm brace to the second arm brace such that the first and second arm braces simultaneously pivot about a first axis. Such a first mechanism can be selectively toggled between unlocked and locked positions such that a desired angle is adjustably and fixedly defined between the first and second arm braces during the golf swing motion respectively. Further, a second mechanism may be provided for resiliently articulating the first and second arm braces about a second axis registered orthogonal to the first axis such that the first and second swivel mounts independently reciprocate along mutually exclusive arcuate paths adjoining the first and second arm braces respectively.