Patents by Inventor Nicholas Rui Yuan HO

Nicholas Rui Yuan HO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • VISUAL AND MODULAR DETECTION OF NUCLEIC ACIDS WITH ENZYME-ASSISTED NANOTECHNOLOGY
    Publication number: 20210130870
    Abstract: The present invention provides methods and devices for specific detection of nucleic acids using an integrated circuit of two independent enzyme-DNA nanostructures—an easily adjustable recognition element and a sensitive universal signaling element—to decouple target recognition and visual signal amplification. The recognition element comprises a DNA polymerase enzyme, a DNA polymerase enzyme-specific DNA aptamer and an inverter oligonucleotide. In the presence of a target nucleic acid, the inverter oligonucleotide binds to the target nucleic acid and releases the DNA polymerase enzyme from inhibition by the DNA aptamer.
    Type: Application
    Filed: July 2, 2019
    Publication date: May 6, 2021
    Applicants: National University of Singapore, Agency for Science, Technology and Research
    Inventors: Huilin SHAO, Nicholas Rui Yuan HO